/***************************************************************************
 *   Copyright (C) 2009-2015 by                                            *
 *   BUI Quang Minh <minh.bui@univie.ac.at>                                *
 *   Lam-Tung Nguyen <nltung@gmail.com>                                    *
 *                                                                         *
 *                                                                         *
 *   This program is free software; you can redistribute it and/or modify  *
 *   it under the terms of the GNU General Public License as published by  *
 *   the Free Software Foundation; either version 2 of the License, or     *
 *   (at your option) any later version.                                   *
 *                                                                         *
 *   This program is distributed in the hope that it will be useful,       *
 *   but WITHOUT ANY WARRANTY; without even the implied warranty of        *
 *   MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the         *
 *   GNU General Public License for more details.                          *
 *                                                                         *
 *   You should have received a copy of the GNU General Public License     *
 *   along with this program; if not, write to the                         *
 *   Free Software Foundation, Inc.,                                       *
 *   59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.             *
 ***************************************************************************/

#ifdef HAVE_CONFIG_H
#include <config.h>
#endif
#include <iqtree_config.h>
#include "tree/phylotree.h"
#include "tree/phylosupertree.h"
#include "tree/phylosupertreeplen.h"
#include "tree/phylosupertreeunlinked.h"
#include "phyloanalysis.h"
#include "alignment/alignment.h"
#include "alignment/superalignment.h"
#include "alignment/superalignmentunlinked.h"
#include "tree/iqtree.h"
#include "tree/iqtreemix.h"
#include "tree/iqtreemixhmm.h"
#include "tree/phylotreemixlen.h"
#include "model/modelmarkov.h"
#include "model/modeldna.h"
#include "model/modelpomo.h"
#include "nclextra/myreader.h"
#include "model/rateheterogeneity.h"
#include "model/rategamma.h"
#include "model/rateinvar.h"
#include "model/rategammainvar.h"
//#include "modeltest_wrapper.h"
#include "model/modelprotein.h"
#include "model/modelbin.h"
#include "model/modelcodon.h"
#include "utils/stoprule.h"

#include "tree/mtreeset.h"
#include "tree/mexttree.h"
#include "model/ratemeyerhaeseler.h"
#include "whtest/whtest_wrapper.h"
#include "model/partitionmodel.h"
#include "model/modelmixture.h"
#include "model/modelfactorymixlen.h"
//#include "guidedbootstrap.h"
#include "model/modelset.h"
#include "utils/timeutil.h"
#include "tree/upperbounds.h"
#include "utils/MPIHelper.h"
#include "timetree.h"

#ifdef USE_BOOSTER
extern "C" {
#include "booster/booster.h"
}
#endif

#ifdef IQTREE_TERRAPHAST
    #include "terracetphast/terracetphast.h"
#endif

void reportReferences(Params &params, ofstream &out) {

    out << "To cite IQ-TREE please use:" << endl << endl
    << "Bui Quang Minh, Heiko A. Schmidt, Olga Chernomor, Dominik Schrempf," << endl
    << "Michael D. Woodhams, Arndt von Haeseler, and Robert Lanfear (2020)" << endl
    << "IQ-TREE 2: New models and efficient methods for phylogenetic inference" << endl
    << "in the genomic era. Mol. Biol. Evol., in press." << endl
    << "https://doi.org/10.1093/molbev/msaa015" << endl << endl;
    
    bool modelfinder_only = false;
    if (params.model_name.substr(0,4) == "TEST" || params.model_name.substr(0, 2) == "MF" || params.model_name.empty()) {
        out << "To cite ModelFinder please use: " << endl << endl
            << "Subha Kalyaanamoorthy, Bui Quang Minh, Thomas KF Wong, Arndt von Haeseler," << endl
            << "and Lars S Jermiin (2017) ModelFinder: Fast model selection for" << endl
            << "accurate phylogenetic estimates. Nature Methods, 14:587–589." << endl
            << "https://doi.org/10.1038/nmeth.4285" << endl << endl;
        if (params.model_name.find("ONLY") != string::npos || (params.model_name.substr(0,2)=="MF" && params.model_name.substr(0,3)!="MFP"))
            modelfinder_only = true;
    }
    if (posPOMO(params.model_name) != string::npos) {
        out << "For polymorphism-aware models please cite:" << endl << endl
            << "Dominik Schrempf, Bui Quang Minh, Nicola De Maio, Arndt von Haeseler, and Carolin Kosiol" << endl
            << "(2016) Reversible polymorphism-aware phylogenetic models and their application to" << endl
            << "tree inference. J. Theor. Biol., 407:362–370." << endl
            << "https://doi.org/10.1016/j.jtbi.2016.07.042" << endl << endl;
    }

    if (params.site_freq_file || params.tree_freq_file)
    out << "Since you used site-specific frequency model please also cite: " << endl << endl
        << "Huai-Chun Wang, Edward Susko, Bui Quang Minh, and Andrew J. Roger (2018)" << endl
        << "Modeling site heterogeneity with posterior mean site frequency profiles" << endl
        << "accelerates accurate phylogenomic estimation. Syst. Biol., 67:216–235." << endl
        << "https://doi.org/10.1093/sysbio/syx068" << endl << endl;


    if (params.gbo_replicates)
    out << "Since you used ultrafast bootstrap (UFBoot) please also cite: " << endl << endl
        << "Diep Thi Hoang, Olga Chernomor, Arndt von Haeseler, Bui Quang Minh," << endl
        << "and Le Sy Vinh (2018) UFBoot2: Improving the ultrafast bootstrap" << endl
        << "approximation. Mol. Biol. Evol., 35:518–522." << endl
        << "https://doi.org/10.1093/molbev/msx281" << endl << endl;

    if (params.partition_file)
    out << "Since you used partition models please also cite:" << endl << endl
        << "Olga Chernomor, Arndt von Haeseler, and Bui Quang Minh (2016)" << endl
        << "Terrace aware data structure for phylogenomic inference from" << endl
        << "supermatrices. Syst. Biol., 65:997-1008." << endl
        << "https://doi.org/10.1093/sysbio/syw037" << endl << endl;

    if (params.terrace_analysis_tphast)
    out << "Since you used terrace analysis please also cite:" << endl << endl
        << "Biczok R, Bozsoky P, Eisenmann P, Ernst J, Ribizel T, Scholz F," << endl
        << "Trefzer A, Weber F, Hamann M, Stamatakis A. (2018)" << endl
        << "Two C++ libraries for counting trees on a phylogenetic" << endl
        << "terrace. Bioinformatics 34:3399–3401." << endl
        << "https://doi.org/10.1093/bioinformatics/bty384" << endl << endl;

    if (params.dating_method == "LSD")
        out << "Since you used least square dating (LSD) please also cite: " << endl << endl
        << "Thu-Hien To, Matthieu Jung, Samantha Lycett, Olivier Gascuel (2016)" << endl
        << "Fast dating using least-squares criteria and algorithms. Syst. Biol. 65:82-97." << endl
        << "https://doi.org/10.1093/sysbio/syv068" << endl << endl;
}

void reportAlignment(ofstream &out, Alignment &alignment, int nremoved_seqs) {
    out << "Input data: " << alignment.getNSeq()+nremoved_seqs << " sequences with "
            << alignment.getNSite() << " ";
    switch (alignment.seq_type) {
    case SEQ_BINARY: out << "binary"; break;
    case SEQ_DNA: out << "nucleotide"; break;
    case SEQ_PROTEIN: out << "amino-acid"; break;
    case SEQ_CODON: out << "codon"; break;
    case SEQ_MORPH: out << "morphological"; break;
    case SEQ_POMO: out << "PoMo"; break;
    default: out << "unknown"; break;
    }
    out << " sites" << endl << "Number of constant sites: "
        << round(alignment.frac_const_sites * alignment.getNSite())
        << " (= " << alignment.frac_const_sites * 100 << "% of all sites)" << endl

        << "Number of invariant (constant or ambiguous constant) sites: "
        << round(alignment.frac_invariant_sites * alignment.getNSite())
        << " (= " << alignment.frac_invariant_sites * 100 << "% of all sites)" << endl

        << "Number of parsimony informative sites: " << alignment.num_informative_sites << endl

        << "Number of distinct site patterns: " << alignment.size() << endl
        << endl;
}

/*
void pruneModelInfo(ModelCheckpoint &model_info, PhyloSuperTree *tree) {
    ModelCheckpoint res_info;
    for (vector<PartitionInfo>::iterator it = tree->part_info.begin(); it != tree->part_info.end(); it++) {
        for (ModelCheckpoint::iterator mit = model_info.begin(); mit != model_info.end(); mit++)
            if (mit->set_name == it->name)
                res_info.push_back(*mit);
    }
    model_info = res_info;

}
*/
void reportModelSelection(ofstream &out, Params &params, ModelCheckpoint *model_info, PhyloTree *tree) {
    out << "Best-fit model according to " << criterionName(params.model_test_criterion) << ": ";
//    ModelCheckpoint::iterator it;
    string best_model;
    PhyloSuperTree *stree = (tree->isSuperTree()) ? ((PhyloSuperTree*)tree) : NULL;
    if (tree->isSuperTree()) {
        SuperAlignment *saln = (SuperAlignment*)stree->aln;
        for (int part = 0; part != stree->size(); part++) {
            if (part != 0)
                out << ",";
            out << saln->partitions[part]->model_name << ":" << saln->partitions[part]->name;
        }
//        string set_name = "";
//        for (it = model_info.begin(); it != model_info.end(); it++) {
//            if (it->set_name != set_name) {
//                if (set_name != "")
//                    out << ",";
//                out << it->name << ":" << it->set_name;
//                set_name = it->set_name;
//            }
//        }
    } else {
//        out << model_info[0].name;
        model_info->getBestModel(best_model);
        out << best_model;
    }

    if (tree->isSuperTree()) {
        out << endl << endl << "List of best-fit models per partition:" << endl << endl;
    } else {
        out << endl << endl << "List of models sorted by "
            << ((params.model_test_criterion == MTC_BIC) ? "BIC" :
                ((params.model_test_criterion == MTC_AIC) ? "AIC" : "AICc"))
            << " scores: " << endl << endl;
    }
    if (tree->isSuperTree())
        out << "  ID  ";
    out << "Model                  LogL         AIC      w-AIC        AICc     w-AICc         BIC      w-BIC" << endl;
    /*
    if (is_partitioned)
        out << "----------";

    out << "----------------------------------------------------------------------------------------" << endl;
    */
    int setid = 1;
    out.precision(3);

    CandidateModelSet models;
    model_info->getOrderedModels(tree, models);
    for (auto it = models.begin(); it != models.end(); it++) {
        if (tree->isSuperTree()) {
            out.width(4);
            out << right << setid << "  ";
            setid++;
        }
        out.width(15);
        out << left << it->getName() << " ";
        out.width(11);
        out << right << it->logl << " ";
        out.width(11);
        out    << it->AIC_score << ((it->AIC_conf) ? " + " : " - ");
        out.unsetf(ios::fixed);
        out.width(8);
        out << it->AIC_weight << " ";
        out.setf(ios::fixed);
        out.width(11);
        out << it->AICc_score << ((it->AICc_conf) ? " + " : " - ");
        out.unsetf(ios::fixed);
        out.width(8);
        out << it->AICc_weight << " ";
        out.setf(ios::fixed);
        out.width(11);
        out << it->BIC_score  << ((it->BIC_conf) ? " + " : " - ");
        out.unsetf(ios::fixed);
        out.width(8);
        out << it->BIC_weight;
        out.setf(ios::fixed);
        out << endl;
    }
    out.precision(4);

    /* TODO
    for (it = model_info.begin(); it != model_info.end(); it++) {
        if (it->AIC_score == DBL_MAX) continue;
        if (it != model_info.begin() && it->set_name != (it-1)->set_name)
            setid++;
        if (is_partitioned && it != model_info.begin() && it->set_name == (it-1)->set_name)
            continue;
        if (is_partitioned) {
            out.width(4);
            out << right << setid << "  ";
        }
        out.width(15);
        out << left << it->name << " ";
        out.width(11);
        out << right << it->logl << " ";
        out.width(11);
        out    << it->AIC_score << ((it->AIC_conf) ? " + " : " - ") << it->AIC_weight << " ";
        out.width(11);
        out << it->AICc_score << ((it->AICc_conf) ? " + " : " - ") << it->AICc_weight << " ";
        out.width(11);
        out << it->BIC_score  << ((it->BIC_conf) ? " + " : " - ") << it->BIC_weight;
        out << endl;
    }
    */
    out << endl;
    out <<  "AIC, w-AIC   : Akaike information criterion scores and weights." << endl
         << "AICc, w-AICc : Corrected AIC scores and weights." << endl
         << "BIC, w-BIC   : Bayesian information criterion scores and weights." << endl << endl

         << "Plus signs denote the 95% confidence sets." << endl
         << "Minus signs denote significant exclusion." <<endl;
    out << endl;
}

void reportNexusFile(ostream &out, ModelSubst *m) {
    double full_mat[400];
    int i,j,k;
    double *rate_mat = new double[m->num_states * m->num_states];
    m->getRateMatrix(rate_mat);
    out << "#nexus" << endl;
    out << "begin models;" << endl;
    out << "model GTRPMIX =" << endl;
    out.precision(6);
    if (m->isReversible()) {
        for (i = 0, k = 0; i < m->num_states - 1; i++)
            for (j = i + 1; j < m->num_states; j++, k++) {
                full_mat[i*m->num_states+j] = rate_mat[k];
            }
        for (i = 1; i < m->num_states; i++) {
            for (j = 0; j < i; j++)
                out << " " << full_mat[j*m->num_states+i];
            out << endl;
        }
    } else {
        // non-reversible model
        m->getQMatrix(full_mat);
        for (i = 0; i < m->num_states; i++) {
            for (j = 0; j < m->num_states; j++)
                out << " " << full_mat[i*m->num_states+j];
            out << endl;
        }
    }
    // print out the frequencies with same rate
    double f = 1.0 / m->num_states;
    for (i = 0; i < m->num_states; i++)
        out << " " << f;
    out << ";" << endl;
    out.precision(4);
    out << "end;" << endl;
}

void reportLinkSubstMatrix(ostream &out, Alignment *aln, ModelSubst *m) {
    int i, j, k;
    double *rate_mat = new double[m->num_states * m->num_states];
    if (!m->isSiteSpecificModel())
        m->getRateMatrix(rate_mat);
    else
        ((ModelSet*)m)->front()->getRateMatrix(rate_mat);

    if (m->num_states <= 4) {
        out << "Linked rate parameter R:" << endl << endl;

        if (m->isReversible()) {
            for (i = 0, k = 0; i < m->num_states - 1; i++)
                for (j = i + 1; j < m->num_states; j++, k++) {
                    out << "  " << aln->convertStateBackStr(i) << "-" << aln->convertStateBackStr(j) << ": "
                            << rate_mat[k];
                    if (m->num_states <= 4)
                        out << endl;
                    else if (k % 5 == 4)
                        out << endl;
                }

        } else { // non-reversible model
            for (i = 0, k = 0; i < m->num_states; i++)
                for (j = 0; j < m->num_states; j++)
                    if (i != j) {
                        out << "  " << aln->convertStateBackStr(i) << "-" << aln->convertStateBackStr(j)
                                << ": " << rate_mat[k];
                        if (m->num_states <= 4)
                            out << endl;
                        else if (k % 5 == 4)
                            out << endl;
                        k++;
                    }

        }
        out << endl << endl;
        out.unsetf(ios_base::fixed);
    } else if (aln->seq_type == SEQ_PROTEIN && m->getNDim() > 20) {
        ASSERT(m->num_states == 20);
        double full_mat[400];
        
        out.precision(6);

        if (m->isReversible()) {
            for (i = 0, k = 0; i < m->num_states - 1; i++)
                for (j = i + 1; j < m->num_states; j++, k++) {
                    full_mat[i*m->num_states+j] = rate_mat[k];
                }
            out << "Linked substitution parameters (lower-diagonal):" << endl << endl;
            for (i = 1; i < m->num_states; i++) {
                for (j = 0; j < i; j++)
                    out << " " << full_mat[j*m->num_states+i];
                out << endl;
            }
        } else {
            // non-reversible model
            m->getQMatrix(full_mat);
            out << "Linked full Q matrix:" << endl << endl;
            for (i = 0; i < m->num_states; i++) {
                for (j = 0; j < m->num_states; j++)
                    out << " " << full_mat[i*m->num_states+j];
                out << endl;
            }
        }
        out << endl;
        out.precision(4);
    }
}

void reportModel(ostream &out, Alignment *aln, ModelSubst *m) {
    int i, j, k;
    ASSERT(aln->num_states == m->num_states);
    double *rate_mat = new double[m->num_states * m->num_states];
    if (!m->isSiteSpecificModel())
        m->getRateMatrix(rate_mat);
    else
        ((ModelSet*)m)->front()->getRateMatrix(rate_mat);

    if (m->num_states <= 4) {
        out << "Rate parameter R:" << endl << endl;

        if (m->isReversible()) {
            for (i = 0, k = 0; i < m->num_states - 1; i++)
                for (j = i + 1; j < m->num_states; j++, k++) {
                    out << "  " << aln->convertStateBackStr(i) << "-" << aln->convertStateBackStr(j) << ": "
                            << rate_mat[k];
                    if (m->num_states <= 4)
                        out << endl;
                    else if (k % 5 == 4)
                        out << endl;
                }

        } else { // non-reversible model
            for (i = 0, k = 0; i < m->num_states; i++)
                for (j = 0; j < m->num_states; j++)
                    if (i != j) {
                        out << "  " << aln->convertStateBackStr(i) << "-" << aln->convertStateBackStr(j)
                                << ": " << rate_mat[k];
                        if (m->num_states <= 4)
                            out << endl;
                        else if (k % 5 == 4)
                            out << endl;
                        k++;
                    }

        }

        //if (tree.aln->num_states > 4)
        out << endl;
        out.unsetf(ios_base::fixed);
    } else if (aln->seq_type == SEQ_PROTEIN && m->getNDim() > 20) {
        ASSERT(m->num_states == 20);
        out << "WARNING: This model has " << m->getNDim() + m->getNDimFreq() << " parameters that may be overfitting. Please use with caution!" << endl << endl;
        double full_mat[400];
        
        out.precision(6);

        if (m->isReversible()) {
            for (i = 0, k = 0; i < m->num_states - 1; i++)
                for (j = i + 1; j < m->num_states; j++, k++) {
                    full_mat[i*m->num_states+j] = rate_mat[k];
                }
            out << "Substitution parameters (lower-diagonal) and state frequencies in PAML format (can be used as input for IQ-TREE): " << endl << endl;
            for (i = 1; i < m->num_states; i++) {
                for (j = 0; j < i; j++)
                    out << " " << full_mat[j*m->num_states+i];
                out << endl;
            }
        } else {
            // non-reversible model
            m->getQMatrix(full_mat);
            out << "Full Q matrix and state frequencies (can be used as input for IQ-TREE): " << endl << endl;
            for (i = 0; i < m->num_states; i++) {
                for (j = 0; j < m->num_states; j++)
                    out << " " << full_mat[i*m->num_states+j];
                out << endl;
            }
        }
        double state_freq[20];
        m->getStateFrequency(state_freq);
        for (i = 0; i < m->num_states; i++)
            out << " " << state_freq[i];
        out << endl << endl;
        out.precision(4);
    }
    
    delete[] rate_mat;

    if (aln->seq_type == SEQ_POMO) {
        m->report(out);
        return;
    }

    out << "State frequencies: ";
    if (m->isSiteSpecificModel())
        out << "(site specific frequencies)" << endl << endl;
    else {
        // 2016-11-03: commented out as this is not correct anymore
//        if (!m->isReversible())
//            out << "(inferred from Q matrix)" << endl;
//        else
            switch (m->getFreqType()) {
            case FREQ_EMPIRICAL:
                out << "(empirical counts from alignment)" << endl;
                break;
            case FREQ_ESTIMATE:
                out << "(estimated with maximum likelihood)" << endl;
                break;
            case FREQ_USER_DEFINED:
                out << ((aln->seq_type == SEQ_PROTEIN) ? "(model)" : "(user-defined)") << endl;
                break;
            case FREQ_EQUAL:
                out << "(equal frequencies)" << endl;
                break;
            default:
                break;
            }
        out << endl;

        if ((m->getFreqType() != FREQ_USER_DEFINED || aln->seq_type == SEQ_DNA) && m->getFreqType() != FREQ_EQUAL) {
            double *state_freqs = new double[m->num_states];
            m->getStateFrequency(state_freqs);
            int ncols=(aln->seq_type == SEQ_CODON) ? 4 : 1;
            for (i = 0; i < m->num_states; i++) {
                out << "  pi(" << aln->convertStateBackStr(i) << ") = " << state_freqs[i];
                if (i % ncols == ncols-1)
                    out << endl;
            }
            delete[] state_freqs;
            out << endl;
        }
        if (m->num_states <= 4 || verbose_mode >= VB_MED) {
            // report Q matrix
            if (verbose_mode >= VB_MED)
                out.precision(6);
            double *q_mat = new double[m->num_states * m->num_states];
            m->getQMatrix(q_mat);

            out << "Rate matrix Q:" << endl << endl;
            for (i = 0, k = 0; i < m->num_states; i++) {
                out << "  " << aln->convertStateBackStr(i);
                for (j = 0; j < m->num_states; j++, k++) {
                    out << "  ";
                    out.width(8);
                    out << q_mat[k];
                }
                out << endl;
            }
            out << endl;
            delete[] q_mat;
        }
    }
}

void reportModel(ostream &out, PhyloTree &tree) {
//    int i, j, k;
    int i;

    if (tree.isTreeMix()) {
        IQTreeMix* treemix = (IQTreeMix*) &tree;
        if (treemix->isLinkModel) {
            out << "Linked ";
            reportModel(out, *treemix->at(0));
        } else {
            for (i=0; i<treemix->size(); i++) {
                out << "Tree " << i+1 << "'s ";
                reportModel(out, *treemix->at(i));
            }
        }
        // if (!tree.isHMM()) {
            // show the tree weights
            out << "Tree weights: ";
            for (i=0; i<treemix->size(); i++) {
                if (i>0)
                    out << ", ";
                out << treemix->weights[i];
            }
            out << endl << endl;
        // }
    } else if (tree.getModel()->isMixture() && !tree.getModel()->isPolymorphismAware()) {
        out << "Mixture model of substitution: " << tree.getModelName() << endl;
//        out << "Full name: " << tree.getModelName() << endl;
        ModelSubst *mmodel = tree.getModel();
        out << endl << "  No  Component      Rate    Weight   Parameters" << endl;
        i = 0;
        int nmix = mmodel->getNMixtures();
        
        // force showing full params if running AliSim
        bool show_full_params = tree.params->alisim_active;
        
        for (i = 0; i < nmix; i++) {
            ModelMarkov *m = (ModelMarkov*)mmodel->getMixtureClass(i);
            out.width(4);
            out << right << i+1 << "  ";
            out.width(12);
            out << left << (m)->name << "  ";
            out.width(7);
            out << (m)->total_num_subst << "  ";
            out.width(7);
            out << mmodel->getMixtureWeight(i) << "  " << (m)->getNameParams(show_full_params) << endl;

            if (tree.aln->seq_type == SEQ_POMO) {
                out << endl << "Model for mixture component "  << i+1 << ": " << (m)->name << endl;
                reportModel(out, tree.aln, m);
            }
        }
        if (tree.aln->seq_type != SEQ_POMO && tree.aln->seq_type != SEQ_DNA)
        for (i = 0; i < nmix; i++) {
            ModelMarkov *m = (ModelMarkov*)mmodel->getMixtureClass(i);
            if (m->getFreqType() == FREQ_EQUAL || m->getFreqType() == FREQ_USER_DEFINED)
                continue;
            out << endl << "Model for mixture component "  << i+1 << ": " << (m)->name << endl;
            reportModel(out, tree.aln, m);
        }
        out << endl;
        if (Params::getInstance().optimize_linked_gtr) {
            // linked substitution matrix
            ModelMarkov *m = (ModelMarkov*)mmodel->getMixtureClass(0);
            reportLinkSubstMatrix(out, tree.aln, m);
        }
    } else {
        // Update rate name if continuous gamma is used.
        if (tree.getModelFactory() && tree.getModelFactory()->is_continuous_gamma)
        {
            if (tree.getRate()->getPInvar()>0)
            {
                tree.getRate()->name = "+I+GC";
                tree.getRate()->full_name = "Invar+Continuous Gamma";
            }
            else
            {
                tree.getRate()->name = "+GC";
                tree.getRate()->full_name = "Continuous Gamma";
            }
        }

        out << "Model of substitution: " << tree.getModelName() << endl << endl;
        reportModel(out, tree.aln, tree.getModel());
    }
}

void reportRate_TreeMix(ostream &out, PhyloTree &tree) {
    IQTreeMix* treemix = (IQTreeMix*) &tree;
    if (treemix->isLinkSiteRate) {
        out << "Linked ";
        reportRate(out, *(treemix->at(0)));
    } else {
        for (size_t i=0; i<treemix->size(); i++) {
            out << "Tree " << i+1 << "'s ";
            reportRate(out, *(treemix->at(i)));
        }
    }
}

void reportRate(ostream &out, PhyloTree &tree) {
    
    if (tree.isTreeMix()) {
        reportRate_TreeMix(out, tree);
        return;
    }
    
    RateHeterogeneity *rate_model = tree.getRate();
    // NHANLT: temporarily fixed bug when reporting continuous gamma model
    // Note: I use RateGamma class (to avoid potential bug if users want to use continuous Gamma for the inference process) and an addition flag is_continuous_gamma to detect continuous Gamma
    if (tree.getModelFactory()->is_continuous_gamma)
        out << "Model of rate heterogeneity: Continuous Gamma" << endl;
    else
        out << "Model of rate heterogeneity: " << rate_model->full_name << endl;
    rate_model->writeInfo(out);

    if (rate_model->getNDiscreteRate() > 1 || rate_model->getPInvar() > 0.0) {
        out << endl << " Category  Relative_rate  Proportion" << endl;
        if (rate_model->getPInvar() > 0.0)
            out << "  0         0              " << rate_model->getPInvar()
                    << endl;
        int cats = rate_model->getNDiscreteRate();
        DoubleVector prop;
        if (rate_model->getGammaShape() > 0 || rate_model->getPtnCat(0) < 0) {
            //            prop.resize(cats, (1.0 - rate_model->getPInvar()) / rate_model->getNRate());
            prop.resize(cats);
            for (size_t i = 0; i < cats; i++) {
                prop[i] = rate_model->getProp(i);
            }
        } else {
            prop.resize(cats, 0.0);
            auto   frequencies  = tree.getConvertedSequenceFrequencies();
            size_t num_patterns = tree.aln->getNPattern();
            if (frequencies!=nullptr) {
                for (size_t i = 0; i < num_patterns; i++) {
                    prop[rate_model->getPtnCat(i)] += frequencies[i];
                }
            } else {
                for (size_t i = 0; i < num_patterns; i++) {
                    prop[rate_model->getPtnCat(i)] += tree.aln->at(i).frequency;
                }
            }
            for (size_t i = 0; i < cats; i++) {
                prop[i] /= tree.aln->getNSite();
            }
        }
        if (tree.getModelFactory() && !tree.getModelFactory()->is_continuous_gamma)
            for (size_t i = 0; i < cats; i++) {
                out << "  " << i + 1 << "         ";
                out.width(14);
                out << left << rate_model->getRate(i) << " " << prop[i];
                out << endl;
            }
        if (rate_model->isGammaRate()) {
            out << "Relative rates are computed as " << ((rate_model->isGammaRate() == GAMMA_CUT_MEDIAN) ? "MEDIAN" : "MEAN") <<
                " of the portion of the Gamma distribution falling in the category." << endl;
        }
    }
    /*
    //output ratemat to iqtree file -JD
    if(Params::getInstance().optimize_linked_gtr) { 
        string fname = Params::getInstance().out_prefix;
        fname += ".ratemat";
        ifstream f(fname.c_str());
        if(f.good()) {
            out << endl << "Rate matrix:" << endl;
            cout << endl << "Rate matrix:" << endl;
            string data;
            getline(f,data);
            size_t last = 0;
            size_t next = 0;
            while ((next = data.find(" ", last)) != string::npos) { 
                string outline = data.substr(last, next-last) + " ";
                out << outline;   
                cout << outline;
                last = next + 1; 
            } 
            out << data.substr(last) << endl;
            cout << data.substr(last) << endl;
            if(!Params::getInstance().rates_file) { //delete ratemat files if not using flag to keep them
                remove(fname.c_str());
                remove((fname+"_init").c_str());
            }
        }
        f.close();
    }
    */
    out << endl;
}

void reportTree(ofstream &out, Params &params, PhyloTree &tree, double tree_lh, double lh_variance, double main_tree) {
    size_t ssize = tree.getAlnNSite();
    double epsilon = 1.0 / ssize;
    double totalLen;
    vector<double> totalLens; // for tree mixture
    int df;
    size_t i;
    IQTreeMix* treemix = NULL;

    if (tree.isTreeMix()) {
        treemix = (IQTreeMix*) &tree;
        df = treemix->getNParameters();
        for (i=0; i<treemix->size(); i++) {
            totalLens.push_back(treemix->at(i)->treeLength());
        }
    } else {
        df = tree.getModelFactory()->getNParameters(BRLEN_OPTIMIZE);
        totalLen = tree.treeLength();
    }

    double AIC_score, AICc_score, BIC_score;
    computeInformationScores(tree_lh, df, ssize, AIC_score, AICc_score, BIC_score);

    out << "Log-likelihood of the tree: " << fixed << tree_lh;
    if (lh_variance > 0.0)
        out << " (s.e. " << sqrt(lh_variance) << ")";
    out << endl;
    out    << "Unconstrained log-likelihood (without tree): " << tree.aln->computeUnconstrainedLogL() << endl;

    out << "Number of free parameters (#branches + #model parameters): " << df << endl;
//    if (ssize > df) {
//        if (ssize > 40*df)
//            out    << "Akaike information criterion (AIC) score: " << AIC_score << endl;
//        else
//            out << "Corrected Akaike information criterion (AICc) score: " << AICc_score << endl;
//
//        out << "Bayesian information criterion (BIC) score: " << BIC_score << endl;
//    } else
    out    << "Akaike information criterion (AIC) score: " << AIC_score << endl;
    out << "Corrected Akaike information criterion (AICc) score: " << AICc_score << endl;
    out << "Bayesian information criterion (BIC) score: " << BIC_score << endl;

    if (ssize <= df && main_tree) {

        out << endl
            << "**************************** WARNING ****************************" << endl
            << "Number of parameters (K, model parameters and branch lengths): " << df << endl
            << "Sample size (n, alignment length): " << ssize << endl << endl
            << "Given that K>=n, the parameter estimates might be inaccurate." << endl
            << "Thus, phylogenetic estimates should be interpreted with caution." << endl << endl

            << "Ideally, it is desirable that n >> K. When selecting optimal models," << endl
            << "1. use AIC or BIC if n > 40K;" << endl
            << "2. use AICc or BIC if 40K >= n > K;" << endl
            << "3. be extremely cautious if n <= K" << endl << endl

            << "To improve the situation (3), consider the following options:" << endl
            << "  1. Increase the sample size (n)" << endl
            << "  2. Decrease the number of parameters (K) to be estimated. If" << endl
            << "     possible:" << endl
            << "     a. Remove the least important sequences from the alignment" << endl
            << "     b. Specify some of the parameter values for the substitution"<< endl
            << "        model (e.g., the nucleotide or amino acid frequencies)" << endl
            << "     c. Specify some of the parameter values for the rates-across-" << endl
            << "        sites model (e.g., the shape parameter for the discrete" << endl
            << "        Gamma distribution, the proportion of invariable sites, or" << endl
            << "        the rates of change for different rate categories under" << endl
            << "        the FreeRate model)" << endl << endl
            << "Reference:" << endl
            << "Burnham KR, Anderson DR (2002). Model Selection and Multimodel" << endl
            << "Inference: A Practical Information-Theoretic Approach. Springer," << endl
            << "New York." << endl
            << "************************ END OF WARNING ***********************" << endl;
    }
    out << endl;

    if (tree.aln->seq_type == SEQ_POMO) {
        int N = tree.aln->virtual_pop_size;
        out << "NOTE: The branch lengths of PoMo measure mutations and frequency shifts." << endl;
        out << "To compare PoMo branch lengths to DNA substitution models use the tree length" << endl;
        out << "measured in substitutions per site." << endl << endl;
        out << "PoMo branch length = Substitution model branch length * N * N." << endl << endl;
        out << "Total tree length (sum of branch lengths)" << endl;
        out << " - measured in number of mutations and frequency shifts per site: " << totalLen << endl;
        out << " - measured in number of substitutions per site (divided by N^2): " << totalLen / (N * N) << endl;
    } else {
        if (treemix == NULL) {
            out << "Total tree length (sum of branch lengths): " << totalLen << endl;
        } else {
            out << "Total tree lengths (sum of branch lengths):";
            for (i = 0; i < treemix->size(); i++) {
                out << " " << totalLens[i];
            }
            out << endl;
        }
    }

    if (treemix != NULL) {
        vector<double> totalLenInternals;
        vector<double> totalLenInternalPs;
        for (i = 0; i < treemix->size(); i++) {
            totalLenInternals.push_back(treemix->at(i)->treeLengthInternal(epsilon));
        }
        ASSERT(totalLens.size() == totalLenInternals.size());
        for (i = 0; i < treemix->size(); i++) {
            totalLenInternalPs.push_back(totalLenInternals[i]*100.0 / totalLens[i]);
        }
        out << "Sum of internal branch lengths:";
        for (i = 0; i < treemix->size(); i++) {
            out << " " << totalLenInternals[i] << " (" << totalLenInternalPs[i] << "% of tree length)";
        }
        out << endl << endl;
    } else {
        double totalLenInternal = tree.treeLengthInternal(epsilon);
        double totalLenInternalP = totalLenInternal*100.0 / totalLen;
        if (tree.aln->seq_type == SEQ_POMO) {
            int N = tree.aln->virtual_pop_size;
            double totLenIntSub = totalLenInternal/(N * N);
            out << "Sum of internal branch lengths" << endl;
            out << "- measured in mutations and frequency shifts per site: " << totalLenInternal << " (" << totalLenInternalP << "% of tree length)" << endl;
            out << "- measured in substitutions per site: " << totLenIntSub << " (" << totalLenInternalP << "% of tree length)" << endl;
            out << endl;
        } else {
            out << "Sum of internal branch lengths: " << totalLenInternal << " (" << totalLenInternalP << "% of tree length)" << endl;
            //    out << "Sum of internal branch lengths divided by total tree length: "
            //            << totalLenInternal / totalLen << endl;
            out << endl;
        }
    }

    if (params.partition_type == TOPO_UNLINKED) {
        out << "Tree topologies are unlinked across partitions, thus no drawing will be displayed here" << endl;
        out << endl;
        return;
    }

    if (treemix != NULL) {
        // out << "No drawing will be displayed for mixture of trees here" << endl;
        out << "Trees with branch lengths are provided in the file: " << params.out_prefix << ".treefile" << endl;
        out << endl;
        return;
    }

    //out << "ZERO BRANCH EPSILON = " << epsilon << endl;
    int zero_internal_branches = tree.countZeroInternalBranches(NULL, NULL, epsilon);
    if (zero_internal_branches > 0) {
        //int zero_internal_branches = tree.countZeroInternalBranches(NULL, NULL, epsilon);
        /*
        out << "WARNING: " << zero_branches
                << " branches of near-zero lengths (<" << epsilon << ") and should be treated with caution!"
                << endl;
        */
        out << "WARNING: " << zero_internal_branches
                << " near-zero internal branches (<" << epsilon << ") should be treated with caution"
                << endl;
        /*
        cout << endl << "WARNING: " << zero_branches
                << " branches of near-zero lengths (<" << epsilon << ") and should be treated with caution!"
                << endl;
        */
        out << "         Such branches are denoted by '**' in the figure below"
                << endl << endl;
    }
    int long_branches = tree.countLongBranches(NULL, NULL, params.max_branch_length-0.2);
    if (long_branches > 0) {
        //stringstream sstr;
        out << "WARNING: " << long_branches << " too long branches (>"
            << params.max_branch_length-0.2 << ") should be treated with caution!" << endl;
        //out << sstr.str();
        //cout << sstr.str();
    }

            //<< "Total tree length: " << tree.treeLength() << endl << endl
    tree.sortTaxa();
    if (tree.rooted)
        out << "NOTE: Tree is ROOTED at virtual root '" << tree.root->name << "'" << endl;
    else
        out << "NOTE: Tree is UNROOTED although outgroup taxon '" << tree.root->name << "' is drawn at root" << endl;

    if (tree.isSuperTree() && params.partition_type == BRLEN_OPTIMIZE)
        out    << "NOTE: Branch lengths are weighted average over all partitions" << endl
            << "      (weighted by the number of sites in the partitions)" << endl;
    if (tree.isMixlen())
        out << "NOTE: Branch lengths are weighted average over heterotachy classes" << endl;

    bool is_codon = tree.aln->seq_type == SEQ_CODON;
    if (tree.isSuperTree()) {
        PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
        is_codon = true;
        for (PhyloSuperTree::iterator sit = stree->begin(); sit != stree->end(); sit++)
            if ((*sit)->aln->seq_type != SEQ_CODON) {
                is_codon = false;
                break;
            }
    }
    if (is_codon)
        out << endl << "NOTE: Branch lengths are interpreted as number of nucleotide substitutions per codon site!"
                << endl << "      Rescale them by 1/3 if you want to have #nt substitutions per nt site" << endl;
    if (main_tree) 
    if (params.aLRT_replicates > 0 || params.gbo_replicates || (params.num_bootstrap_samples && params.compute_ml_tree)) {
        out << "Numbers in parentheses are ";
        if (params.aLRT_replicates > 0) {
            out << "SH-aLRT support (%)";
            if (params.localbp_replicates)
                out << " / local bootstrap support (%)";
        }
        if (params.aLRT_test)
            out << " / parametric aLRT support";
        if (params.aBayes_test)
            out << " / aBayes support";
        if (params.num_bootstrap_samples && params.compute_ml_tree) {
            if (params.aLRT_replicates > 0 || params.aLRT_test || params.aBayes_test)
                out << " /";
            out << " standard " << RESAMPLE_NAME << " support (%)";
        }
        if (params.gbo_replicates) {
            if (params.aLRT_replicates > 0 || params.aLRT_test || params.aBayes_test)
                out << " /";
            out << " ultrafast " << RESAMPLE_NAME << " support (%)";
        }
        out << endl;
    }
    out << endl;

    //tree.setExtendedFigChar();
    tree.setRootNode(params.root, true);
    tree.drawTree(out, WT_BR_SCALE, epsilon);

    out << "Tree in newick format:";
    if (tree.isMixlen())
        out << " (class branch lengths are given in [...] and separated by '/' )";
    if (tree.aln->seq_type == SEQ_POMO)
        out << " (measured in mutations and frequency shifts)";
    out << endl << endl;

    tree.printTree(out, WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA);
    out << endl << endl;

  if (tree.aln->seq_type == SEQ_POMO) {
    out << "Tree in newick format (measured in substitutions, see above):" << endl;
    out << "WARNING: Only for comparison with substitution models." << endl;
    out << "         These are NOT the branch lengths inferred by PoMo." << endl << endl;
    double len_scale_old = tree.len_scale;
    int N = tree.aln->virtual_pop_size;
    tree.len_scale = 1.0/(N*N);
    tree.printTree(out, WT_BR_SCALE | WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA);
    tree.len_scale = len_scale_old;
    out << endl << endl;
    }

  tree.setRootNode(params.root, false);

}

void reportCredits(ofstream &out) {
    out << "CREDITS" << endl << "-------" << endl << endl
            << "Some parts of the code were taken from the following packages/libraries:"
            << endl << endl
            << "Schmidt HA, Strimmer K, Vingron M, and von Haeseler A (2002)" << endl
            << "TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets" << endl
            << "and parallel computing. Bioinformatics, 18(3):502-504." << endl << endl

            //<< "The source code to construct the BIONJ tree were taken from BIONJ software:"
            //<< endl << endl
            << "Gascuel O (1997) BIONJ: an improved version of the NJ algorithm" << endl
            << "based on a simple model of sequence data. Mol. Bio. Evol., 14:685-695." << endl << endl

            //<< "The Nexus file parser was taken from the Nexus Class Library:"
            //<< endl << endl
            << "Paul O. Lewis (2003) NCL: a C++ class library for interpreting data files in" << endl
            << "NEXUS format. Bioinformatics, 19(17):2330-2331." << endl << endl

            << "Mascagni M and Srinivasan A (2000) Algorithm 806: SPRNG: A Scalable Library" << endl
            << "for Pseudorandom Number Generation. ACM Transactions on Mathematical Software," << endl
            << "26: 436-461." << endl << endl

            << "Guennebaud G, Jacob B, et al. (2010) Eigen v3. http://eigen.tuxfamily.org" << endl << endl;
            /*
            << "The Modeltest 3.7 source codes were taken from:" << endl << endl
            << "David Posada and Keith A. Crandall (1998) MODELTEST: testing the model of"
            << endl << "DNA substitution. Bioinformatics, 14(9):817-8." << endl
            */
}

/***********************************************************
 * CREATE REPORT FILE
 ***********************************************************/
extern StringIntMap pllTreeCounter;

void exhaustiveSearchGAMMAInvar(Params &params, IQTree &iqtree);

void searchGAMMAInvarByRestarting(IQTree &iqtree);

void computeLoglFromUserInputGAMMAInvar(Params &params, IQTree &iqtree);

void printOutfilesInfo(Params &params, IQTree &tree) {

    cout << endl << "Analysis results written to: " << endl;
    if (!(params.suppress_output_flags & OUT_IQTREE))
        cout<< "  IQ-TREE report:                " << params.out_prefix << ".iqtree"
            << endl;
    if (params.compute_ml_tree) {
        if (!(params.suppress_output_flags & OUT_TREEFILE)) {
            if (params.model_name.find("ONLY") != string::npos || (params.model_name.substr(0,2)=="MF" && params.model_name.substr(0,3)!="MFP"))
                cout << "  Tree used for ModelFinder:     " << params.out_prefix << ".treefile" << endl;
            else {
                cout << "  Maximum-likelihood tree:       " << params.out_prefix << ".treefile" << endl;
                if (params.partition_type == BRLEN_OPTIMIZE && tree.isSuperTree())
                    cout << "  Partition trees:               " << params.out_prefix << ".parttrees" << endl;
            }
        }
//        if (params.snni && params.write_local_optimal_trees) {
//            cout << "  Locally optimal trees (" << tree.candidateTrees.getNumLocalOptTrees() << "):    " << params.out_prefix << ".suboptimal_trees" << endl;
//        }
    }
    if (params.num_runs > 1)
        cout << "  Trees from independent runs:   " << params.out_prefix << ".runtrees" << endl;

    if (!params.user_file && params.start_tree == STT_BIONJ) {
        cout << "  BIONJ tree:                    " << params.out_prefix << ".bionj"
                << endl;
    }
    if (!params.dist_file) {
        //cout << "  Juke-Cantor distances:    " << params.out_prefix << ".jcdist" << endl;
        if (params.compute_ml_dist)
        cout << "  Likelihood distances:          " << params.out_prefix
                    << ".mldist" << endl;
        if (params.print_conaln)
        cout << "  Concatenated alignment:        " << params.out_prefix
                    << ".conaln" << endl;
    }
    if ((params.model_name.find("TEST") != string::npos || params.model_name.substr(0,2) == "MF") && tree.isSuperTree()) {
        cout << "  Best partitioning scheme:      " << params.out_prefix << ".best_scheme.nex" << endl;
        bool raxml_format_printed = true;

        for (auto it = ((SuperAlignment*)tree.aln)->partitions.begin();
                it != ((SuperAlignment*)tree.aln)->partitions.end(); it++)
            if (!(*it)->aln_file.empty()) {
                raxml_format_printed = false;
                break;
            }
        if (raxml_format_printed)
             cout << "           in RAxML format:      " << params.out_prefix << ".best_scheme" << endl;
    }
    if ((tree.getRate()->getGammaShape() > 0 || params.partition_file) && params.print_site_rate)
        cout << "  Site-specific rates:           " << params.out_prefix << ".rate"
                << endl;

    if ((tree.getRate()->isSiteSpecificRate() || tree.getRate()->getPtnCat(0) >= 0) && params.print_site_rate)
        cout << "  Site-rates by MH model:        " << params.out_prefix << ".rate"
                << endl;

    if (params.print_site_lh)
        cout << "  Site log-likelihoods:          " << params.out_prefix << ".sitelh"
                << endl;

    if (params.print_partition_lh)
        cout << "  Partition log-likelihoods:     " << params.out_prefix << ".partlh"
                << endl;

    if (params.print_site_prob)
        cout << "  Site probability per rate/mix: " << params.out_prefix << ".siteprob"
                << endl;
    
    if (params.print_marginal_prob && params.optimize_params_use_hmm)
        cout << "  Marginal probability:          " << params.out_prefix << ".mprob" << endl;

    if (params.print_ancestral_sequence) {
        cout << "  Ancestral state:               " << params.out_prefix << ".state" << endl;
//        cout << "  Ancestral sequences:           " << params.out_prefix << ".aseq" << endl;
    }

    if (params.write_intermediate_trees)
        cout << "  All intermediate trees:        " << params.out_prefix << ".treels"
                << endl;

    if (params.writeDistImdTrees) {
        tree.intermediateTrees.printTrees(string("ditrees"));
        cout << "  Distinct intermediate trees:   " << params.out_prefix <<  ".ditrees" << endl;
        cout << "  Logl of intermediate trees:    " << params.out_prefix <<  ".ditrees_lh" << endl;
    }

    if (params.gbo_replicates) {
        cout << endl << "Ultrafast " << RESAMPLE_NAME << " approximation results written to:" << endl;
        if (!tree.isSuperTreeUnlinked())
            cout << "  Split support values:          " << params.out_prefix << ".splits.nex" << endl
             << "  Consensus tree:                " << params.out_prefix << ".contree" << endl;
        if (tree.rooted) {
            cout << "  ML tree with rootstrap:        " << params.out_prefix << ".rootstrap.nex" << endl;

        }
        if (params.root_test) {
            cout << "  Root testing results:          " << params.out_prefix << ".roottest.csv" << endl;
        }
        if (params.print_ufboot_trees)
        cout << "  UFBoot trees:                  " << params.out_prefix << ".ufboot" << endl;

    }

    if (!params.treeset_file.empty()) {
        cout << "  Evaluated user trees:          " << params.out_prefix << ".trees" << endl;

        if (params.print_tree_lh) {
        cout << "  Tree log-likelihoods:          " << params.out_prefix << ".treelh" << endl;
        }
    }
    if (params.lmap_num_quartets >= 0) {
        cout << "  Likelihood mapping plot (SVG): " << params.out_prefix << ".lmap.svg" << endl;
        cout << "  Likelihood mapping plot (EPS): " << params.out_prefix << ".lmap.eps" << endl;
    }
    if (!(params.suppress_output_flags & OUT_LOG))
        cout << "  Screen log file:               " << params.out_prefix << ".log" << endl;
    /*    if (params.model_name == "WHTEST")
     cout <<"  WH-TEST report:           " << params.out_prefix << ".whtest" << endl;*/

    if (params.optimize_params_use_hmm) {
        cout << "  HMM result file:               " << params.out_prefix << ".hmm" << endl;
        cout << "                                 " << params.out_prefix << ".pp.hmm" << endl;
    }
    
    if (params.optimize_linked_gtr) {
        cout << "  GTRPMIX nex file:              " << params.out_prefix << ".GTRPMIX.nex" << endl;
    }
    cout << endl;

}

void reportSubstitutionProcess(ostream &out, Params &params, IQTree &tree)
{
    if (params.numeric_precision > 0)
        out.precision(params.numeric_precision);
    
    out << "SUBSTITUTION PROCESS" << endl << "--------------------" << endl
            << endl;
    if (tree.isSuperTree()) {
        if(params.partition_type == BRLEN_SCALE)
            out << "Edge-linked-proportional partition model with ";
        else if(params.partition_type == BRLEN_FIX)
            out << "Edge-linked-equal partition model with ";
        else if (params.partition_type == BRLEN_OPTIMIZE)
            out << "Edge-unlinked partition model with ";
        else
            out << "Topology-unlinked partition model with ";
        
        if (params.model_joint)
            out << "joint substitution model ";
        else
            out << "separate substitution models ";
        if (params.link_alpha)
            out << "and joint gamma shape";
        else
            out << "and separate rates across sites";
        out << endl << endl;

        PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
        PhyloSuperTree::iterator it;
        int part;
        
        // force showing full params if running AliSim
        bool show_full_params = tree.params->alisim_active;

        if(params.partition_type == BRLEN_OPTIMIZE || params.partition_type == TOPO_UNLINKED)
            out << "  ID  Model         TreeLen  Parameters" << endl;
        else
            out << "  ID  Model           Speed  Parameters" << endl;
        //out << "-------------------------------------" << endl;
        for (it = stree->begin(), part = 0; it != stree->end(); it++, part++) {
            out.width(4);
            out << right << (part+1) << "  ";
            out.width(14);
            if(params.partition_type == BRLEN_OPTIMIZE || params.partition_type == TOPO_UNLINKED)
                out << left << (*it)->getModelName() << " " << (*it)->treeLength() << "  " << (*it)->getModelNameParams(show_full_params) << endl;
            else
                out << left << (*it)->getModelName() << " " << stree->part_info[part].part_rate  << "  " << (*it)->getModelNameParams(show_full_params) << endl;
        }
        out << endl;
        /*
        for (it = stree->begin(), part = 0; it != stree->end(); it++, part++) {
            reportModel(out, *(*it));
            reportRate(out, *(*it));
        }*/
        PartitionModel *part_model = (PartitionModel*)tree.getModelFactory();
        if (part_model)
            for (auto itm = part_model->linked_models.begin(); itm != part_model->linked_models.end(); itm++) {
                for (it = stree->begin(); it != stree->end(); it++)
                    if ((*it)->getModel() == itm->second) {
                        out << "Linked model of substitution: " << itm->second->getName() << endl << endl;
                        bool fixed = (*it)->getModel()->fixParameters(false);
                        reportModel(out, (*it)->aln, (*it)->getModel());
                        (*it)->getModel()->fixParameters(fixed);
                        break;
                    }
            }
    } else {
        reportModel(out, tree);
        reportRate(out, tree);
    }
}

void reportPhyloAnalysis(Params &params, IQTree &tree, ModelCheckpoint &model_info) {
    if (!MPIHelper::getInstance().isMaster()) {
        return;
    }
    if (params.suppress_output_flags & OUT_IQTREE) {
        printOutfilesInfo(params, tree);
        return;
    }
        
    if (params.count_trees) {
        // addon: print #distinct trees
        cout << endl << "NOTE: " << pllTreeCounter.size() << " distinct trees evaluated during whole tree search" << endl;

        IntVector counts;
        for (StringIntMap::iterator i = pllTreeCounter.begin(); i != pllTreeCounter.end(); i++) {
            if (i->second > counts.size())
                counts.resize(i->second+1, 0);
            counts[i->second]++;
        }
        for (IntVector::iterator i2 = counts.begin(); i2 != counts.end(); i2++) {
            if (*i2 != 0) {
                cout << "#Trees occurring " << (i2-counts.begin()) << " times: " << *i2 << endl;
            }
        }
    }
    string outfile = params.out_prefix;

    outfile += ".iqtree";
    try {
        ofstream out;
        out.exceptions(ios::failbit | ios::badbit);
        out.open(outfile.c_str());
        out << "IQ-TREE " << iqtree_VERSION_MAJOR << "." << iqtree_VERSION_MINOR
            << iqtree_VERSION_PATCH << " built " << __DATE__ << endl
                << endl;
        if (params.partition_file)
            out << "Partition file name: " << params.partition_file << endl;
        if (params.aln_file)
            out << "Input file name: " << params.aln_file << endl;

        if (params.user_file)
            out << "User tree file name: " << params.user_file << endl;
        out << "Type of analysis: ";
        bool modelfinder = params.model_name.substr(0,4)=="TEST" || params.model_name.substr(0,2) == "MF" || params.model_name.empty();
        if (modelfinder)
            out << "ModelFinder";
        if (params.compute_ml_tree) {
            if (modelfinder)
                out << " + ";
            out << "tree reconstruction";
        }
        if (params.num_bootstrap_samples > 0) {
            if (params.compute_ml_tree)
                out << " + ";
            out << "non-parametric " << RESAMPLE_NAME << " (" << params.num_bootstrap_samples
                    << " replicates)";
        }
        if (params.gbo_replicates > 0) {
            out << " + ultrafast " << RESAMPLE_NAME << " (" << params.gbo_replicates << " replicates)";
        }
        out << endl;
        out << "Random seed number: " << params.ran_seed << endl << endl;
        out << "REFERENCES" << endl << "----------" << endl << endl;
        reportReferences(params, out);

        out << "SEQUENCE ALIGNMENT" << endl << "------------------" << endl
                << endl;
        if (tree.isSuperTree()) {
      // TODO DS: Changes may be needed here for PoMo.
            out << "Input data: " << tree.aln->getNSeq()+tree.removed_seqs.size() << " taxa with "
                    << tree.aln->getNSite() << " partitions and "
                    << tree.getAlnNSite() << " total sites ("
                    << ((SuperAlignment*)tree.aln)->computeMissingData()*100 << "% missing data)" << endl << endl;

            PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
            int namelen = stree->getMaxPartNameLength();
            int part;
            out.width(4);
            out << left << "  ID" << "\tType\tSeq\tSite\tUnique\tInfor\tInvar\tConst\tName" << endl;
            //out << string(namelen+54, '-') << endl;
            part = 0;
            for (PhyloSuperTree::iterator it = stree->begin(); it != stree->end(); it++, part++) {
                //out << "FOR PARTITION " << stree->part_info[part].name << ":" << endl << endl;
                //reportAlignment(out, *((*it)->aln));
                out.width(4);
                out << right << part+1;
                out << "\t";
                switch ((*it)->aln->seq_type) {
                case SEQ_BINARY: out << "BIN"; break;
                case SEQ_CODON: out << "CODON"; break;
                case SEQ_DNA: out << "DNA"; break;
                case SEQ_MORPH: out << "MORPH"; break;
                case SEQ_MULTISTATE: out << "MULTI"; break;
                case SEQ_PROTEIN: out << "AA"; break;
                case SEQ_POMO: out << "POMO"; break;
                case SEQ_UNKNOWN: out << "???"; break;
                }
                out << "\t" << (*it)->aln->getNSeq() << "\t" << (*it)->aln->getNSite()
                    << "\t" << (*it)->aln->getNPattern() << "\t" << (*it)->aln->num_informative_sites
                    << "\t" << (*it)->getAlnNSite() - (*it)->aln->num_variant_sites
                    << "\t" << round((*it)->aln->frac_const_sites*(*it)->getAlnNSite())
                    << "\t";
                out << left << (*it)->aln->name;
                out << endl;
            }
            out << endl << "Column meanings:" << endl
                << "  Unique: Number of unique site patterns" << endl
                << "  Infor:  Number of parsimony-informative sites" << endl
                << "  Invar:  Number of invariant sites" << endl
                << "  Const:  Number of constant sites (can be subset of invariant sites)" << endl << endl;

        } else
            reportAlignment(out, *(tree.aln), tree.removed_seqs.size());

        out.precision(4);
        out << fixed;

        if (!model_info.empty()) {
            out << "ModelFinder" << endl << "-----------" << endl << endl;
//            if (tree.isSuperTree())
//                pruneModelInfo(model_info, (PhyloSuperTree*)&tree);
            reportModelSelection(out, params, &model_info, &tree);
        }

/*
        out << "SUBSTITUTION PROCESS" << endl << "--------------------" << endl
                << endl;
        if (tree.isSuperTree()) {
            if(params.partition_type == BRLEN_SCALE)
                out << "Edge-linked-proportional partition model with ";
            else if(params.partition_type == BRLEN_FIX)
                out << "Edge-linked-equal partition model with ";
            else if (params.partition_type == BRLEN_OPTIMIZE)
                out << "Edge-unlinked partition model with ";
            else
                out << "Topology-unlinked partition model with ";
            
            if (params.model_joint)
                out << "joint substitution model ";
            else
                out << "separate substitution models ";
            if (params.link_alpha)
                out << "and joint gamma shape";
            else
                out << "and separate rates across sites";
            out << endl << endl;

            PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
            PhyloSuperTree::iterator it;
            int part;
            if(params.partition_type == BRLEN_OPTIMIZE || params.partition_type == TOPO_UNLINKED)
                out << "  ID  Model         TreeLen  Parameters" << endl;
            else
                out << "  ID  Model           Speed  Parameters" << endl;
            //out << "-------------------------------------" << endl;
            for (it = stree->begin(), part = 0; it != stree->end(); it++, part++) {
                out.width(4);
                out << right << (part+1) << "  ";
                out.width(14);
                if(params.partition_type == BRLEN_OPTIMIZE || params.partition_type == TOPO_UNLINKED)
                    out << left << (*it)->getModelName() << " " << (*it)->treeLength() << "  " << (*it)->getModelNameParams() << endl;
                else
                    out << left << (*it)->getModelName() << " " << stree->part_info[part].part_rate  << "  " << (*it)->getModelNameParams() << endl;
            }
            out << endl;
            PartitionModel *part_model = (PartitionModel*)tree.getModelFactory();
            for (auto itm = part_model->linked_models.begin(); itm != part_model->linked_models.end(); itm++) {
                for (it = stree->begin(); it != stree->end(); it++)
                    if ((*it)->getModel() == itm->second) {
                        out << "Linked model of substitution: " << itm->second->getName() << endl << endl;
                        bool fixed = (*it)->getModel()->fixParameters(false);
                        reportModel(out, (*it)->aln, (*it)->getModel());
                        (*it)->getModel()->fixParameters(fixed);
                        break;
                    }
            }
        } else {
            reportModel(out, tree);
            reportRate(out, tree);
        }
*/

        reportSubstitutionProcess(out, params, tree);

            if (params.lmap_num_quartets >= 0) {
            tree.reportLikelihoodMapping(out);
        }


        /*
        out << "RATE HETEROGENEITY" << endl << "------------------" << endl
                << endl;
        if (tree.isSuperTree()) {
            PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
            int part = 0;
            for (PhyloSuperTree::iterator it = stree->begin();
                    it != stree->end(); it++, part++) {
                out << "FOR PARTITION " << stree->part_info[part].name << ":"
                        << endl << endl;
                reportRate(out, *(*it));
            }
        } else
            reportRate(out, tree);
        */
        // Bootstrap analysis:
        //Display as outgroup: a

        if (params.model_name == "WHTEST") {
            out << "TEST OF MODEL HOMOGENEITY" << endl
                    << "-------------------------" << endl << endl;
            out << "Delta of input data:                 "
                    << params.whtest_delta << endl;
            out << ".95 quantile of Delta distribution:  "
                    << params.whtest_delta_quantile << endl;
            out << "Number of simulations performed:     "
                    << params.whtest_simulations << endl;
            out << "P-value:                             "
                    << params.whtest_p_value << endl;
            if (params.whtest_p_value < 0.05) {
                out
                        << "RESULT: Homogeneity assumption is rejected (p-value cutoff 0.05)"
                        << endl;
            } else {
                out
                        << "RESULT: Homogeneity assumption is NOT rejected (p-value cutoff 0.05)"
                        << endl;
            }
            out << endl << "*** For this result please cite:" << endl << endl;
            out
                    << "G. Weiss and A. von Haeseler (2003) Testing substitution models"
                    << endl
                    << "within a phylogenetic tree. Mol. Biol. Evol, 20(4):572-578"
                    << endl << endl;
        }
        
        if (params.num_runs > 1) {
            out << "MULTIPLE RUNS" << endl
                << "-------------" << endl << endl;
            out << "Run     logL" << endl;
            DoubleVector runLnL;
            tree.getCheckpoint()->getVector("runLnL", runLnL);
            for (int run = 0; run < runLnL.size(); run++)
                out << run+1 << "\t" << fixed << runLnL[run] << endl;
            out << endl;
        }
/*
        out << "TREE SEARCH" << endl << "-----------" << endl << endl
                << "Stopping rule: "
                << ((params.stop_condition == SC_STOP_PREDICT) ? "Yes" : "No")
                << endl << "Number of iterations: "
                << tree.stop_rule.getNumIterations() << endl
                << "Probability of deleting sequences: " << params.p_delete
                << endl << "Number of representative leaves: "
                << params.k_representative << endl
                << "NNI log-likelihood cutoff: " << tree.getNNICutoff() << endl
                << endl;
*/
        if (params.compute_ml_tree) {
            if (params.model_name.find("ONLY") != string::npos || (params.model_name.substr(0,2) == "MF" && params.model_name.substr(0,3) != "MFP")) {
                out << "TREE USED FOR ModelFinder" << endl
                    << "-------------------------" << endl << endl;
            } else if (params.min_iterations == 0) {
                if (params.user_file)
                    out << "USER TREE" << endl
                        << "---------" << endl << endl;
                else
                    out << "STARTING TREE" << endl
                        << "-------------" << endl << endl;
            } else {
                out << "MAXIMUM LIKELIHOOD TREE" << endl
                    << "-----------------------" << endl << endl;
            }

            tree.setRootNode(params.root);

            if (params.gbo_replicates) {
                if (tree.boot_consense_logl > tree.getBestScore() + 0.1 && !tree.isSuperTreeUnlinked()) {
                    out << endl << "**NOTE**: Consensus tree has higher likelihood than ML tree found! Please use consensus tree below." << endl;
                }
            }

            reportTree(out, params, tree, tree.getBestScore(), tree.logl_variance, true);

            if (tree.isSuperTree() && verbose_mode >= VB_MED) {
                PhyloSuperTree *stree = (PhyloSuperTree*) &tree;
//                stree->mapTrees();
//                int empty_branches = stree->countEmptyBranches();
//                if (empty_branches) {
//                    stringstream ss;
//                    ss << empty_branches << " branches in the overall tree with no phylogenetic information due to missing data!";
//                    outWarning(ss.str());
//                }

                int part = 0;
                for (PhyloSuperTree::iterator it = stree->begin();
                        it != stree->end(); it++, part++) {
                    out << "FOR PARTITION " << (*it)->aln->name
                            << ":" << endl << endl;
                    (*it)->setRootNode(params.root);
//                    reportTree(out, params, *(*it), (*it)->computeLikelihood(), (*it)->computeLogLVariance(), false);
                    reportTree(out, params, *(*it), stree->part_info[part].cur_score, 0.0, false);
                }
            }

        }
        /*
         if (params.write_intermediate_trees) {
         out << endl << "CONSENSUS OF INTERMEDIATE TREES" << endl << "-----------------------" << endl << endl
         << "Number of intermediate trees: " << tree.stop_rule.getNumIterations() << endl
         << "Split threshold: " << params.split_threshold << endl
         << "Burn-in: " << params.tree_burnin << endl << endl;
         }*/

        if (params.consensus_type == CT_CONSENSUS_TREE && !tree.isSuperTreeUnlinked()) {
            out << "CONSENSUS TREE" << endl << "--------------" << endl << endl;
            out << "Consensus tree is constructed from "
                    << (params.num_bootstrap_samples ? params.num_bootstrap_samples : params.gbo_replicates)
                    << " " << RESAMPLE_NAME << " trees";
            if (params.gbo_replicates || params.num_bootstrap_samples) {
                out << endl << "Log-likelihood of consensus tree: " << fixed << tree.boot_consense_logl;
            }
            string con_file = params.out_prefix;
            con_file += ".contree";

            // -- Mon Apr 17 21:14:53 BST 2017
            // DONE Minh: merged correctly
            if (params.compute_ml_tree)
                out << endl << "Robinson-Foulds distance between ML tree and consensus tree: "
                    << tree.contree_rfdist << endl;
            // --
            
            out << endl << "Branches with support >"
                    << floor(params.split_threshold * 1000) / 10 << "% are kept";
            if (params.split_threshold == 0.0)
                out << " (extended consensus)";
            if (params.split_threshold == 0.5)
                out << " (majority-rule consensus)";
            if (params.split_threshold >= 0.99)
                out << " (strict consensus)";

            out << endl << "Branch lengths are optimized by maximum likelihood on original alignment" << endl;
            out << "Numbers in parentheses are " << RESAMPLE_NAME << " supports (%)" << endl << endl;

            bool rooted = false;
            MTree contree;
            contree.readTree(con_file.c_str(), rooted);
            contree.drawTree(out, WT_BR_SCALE);
            out << endl << "Consensus tree in newick format: " << endl << endl;
            contree.printTree(out);
            out << endl << endl;
//            tree.freeNode();
//            tree.root = NULL;
//            tree.readTree(con_file.c_str(), rooted);
//            if (removed_seqs.size() > 0) {
//                tree.reinsertIdenticalSeqs(tree.aln, removed_seqs, twin_seqs);
//            }
//            tree.setAlignment(tree.aln);

            // bug fix
//            if ((tree.sse == LK_EIGEN || tree.sse == LK_EIGEN_SSE) && !tree.isBifurcating()) {
//                cout << "NOTE: Changing to old kernel as consensus tree is multifurcating" << endl;
//                tree.changeLikelihoodKernel(LK_SSE);
//            }

//            tree.initializeAllPartialLh();
//            tree.fixNegativeBranch(false);
//            if (tree.isSuperTree())
//                ((PhyloSuperTree*) &tree)->mapTrees();
//            tree.optimizeAllBranches();
//            tree.printTree(con_file.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA);
//            tree.sortTaxa();
//            tree.drawTree(out, WT_BR_SCALE);
//            out << endl << "Consensus tree in newick format: " << endl << endl;
//            tree.printResultTree(out);
//            out << endl << endl;
        }
#ifdef IQTREE_TERRAPHAST
        if (params.terrace_analysis_tphast && params.compute_ml_tree) {
            
            out << "TERRACE ANALYSIS" << endl << "----------------" << endl << endl;
            cout << "Running additional analysis: Phylogenetic Terraces ..."<< endl;
            
            string filename = params.out_prefix;
            filename += ".terrace";

            try
            {
                TerraceTP terrace(tree, (SuperAlignment*)(tree.aln));

                uint64_t terrace_size = terrace.getSize();

                if (terrace_size == 1) {
                    out << "The tree does not lie on a terrace." << endl;
                } else {
                    out << "The tree lies on a terrace of size ";

                    if (terrace_size == UINT64_MAX) {
                        out << "at least " << terrace_size << " (integer overflow)";
                    } else {
                        out << terrace_size;
                    }

                    out << endl;

                    ofstream terraceout;
                    terraceout.open(filename.c_str());

                    terrace.printTreesCompressed(terraceout);

                    terraceout.close();

                    out << "Terrace trees written (in compressed Newick format) to " << filename << endl;
                }
            }
            catch (std::exception& e)
            {
                out << "ERROR: Terrace analysis using Terraphast failed: " << e.what() << endl << endl;
            }

            out << endl;
            out << "For documentation, see the technical supplement to Biczok et al. (2018)" << endl;
            out << "https://doi.org/10.1093/bioinformatics/bty384";

            out << endl << endl;
            cout<< "Done. Results are written in "<<params.out_prefix<<".iqtree file."<<endl;
        }
#endif
        
        if (params.terrace_check && params.partition_file && params.compute_ml_tree) {
            
            cout<<"\n-------------------------------------------------------------------\n";
            cout<<"The --terrace option is currently not available. Please, perform terrace analysis in a separate run using the following command line:\n";
            cout<<"iqtree2 --gentrius <tree_file> -s <aln_file> -p <part_info_file>\n";
            cout<<"For more information refer to the manual.\n";
            cout<<"-------------------------------------------------------------------\n";
            
            //out << "TERRACE ANALYSIS" << endl << "----------------" << endl << endl;
            //cout << "Running additional analysis: Phylogenetic Terraces ..."<< endl;
            
            //string filename = params.out_prefix;
            //filename += ".terrace";
            
            // Integrate a terrace check for partitioned analysis
        }
        
        /* evaluate user trees */
        vector<TreeInfo> info;
        IntVector distinct_trees;
        if (!params.treeset_file.empty()) {
            evaluateTrees(params.treeset_file, params, &tree, info, distinct_trees);
            out.precision(4);
            out.setf(ios_base::fixed);

			out << endl << "USER TREES" << endl << "----------" << endl << endl;
			out << "See " << params.out_prefix << ".trees for trees with branch lengths." << endl << endl;
			if (params.topotest_replicates && info.size() > 1) {
                if (params.do_au_test && params.topotest_replicates < 10000)
                    out << "WARNING: Too few replicates for AU test. At least -zb 10000 for reliable results!" << endl << endl;
                out << "Tree      logL    deltaL  bp-RELL    p-KH     p-SH    ";
				if (params.do_weighted_test)
					out << "p-WKH    p-WSH    ";
                out << "   c-ELW";
                if (params.do_au_test)
                    out << "       p-AU";

                out << endl << "------------------------------------------------------------------";
                if (params.do_weighted_test)
                    out << "------------------";
                if (params.do_au_test)
                    out << "-------";
                out << endl;
			} else {
				out << "Tree      logL    deltaL" << endl;
				out << "-------------------------" << endl;

			}
			double maxL = -DBL_MAX;
			int tid, orig_id;
			for (tid = 0; tid < info.size(); tid++)
				if (info[tid].logl > maxL) maxL = info[tid].logl;
			for (orig_id = 0, tid = 0; orig_id < distinct_trees.size(); orig_id++) {
				out.width(3);
				out << right << orig_id+1 << " ";
				if (distinct_trees[orig_id] >= 0) {
					out << " = tree " << distinct_trees[orig_id]+1 << endl;
					continue;
				}
                out.unsetf(ios::fixed);
				out.precision(10);
				out.width(12);
				out << info[tid].logl << " ";
				out.width(7);
                out.precision(5);
				out << maxL - info[tid].logl;
				if (!params.topotest_replicates || info.size() <= 1) {
					out << endl;
					tid++;
					continue;
				}
				out.precision(3);
				out << "  ";
				out.width(6);
				out << info[tid].rell_bp;
				if (info[tid].rell_confident)
					out << " + ";
				else
					out << " - ";
				out.width(6);
				out << right << info[tid].kh_pvalue;
				if (info[tid].kh_pvalue < 0.05)
					out << " - ";
				else
					out << " + ";
				out.width(6);
				out << right << info[tid].sh_pvalue;
				if (info[tid].sh_pvalue < 0.05)
					out << " - ";
				else
					out << " + ";

				if (params.do_weighted_test) {
					out.width(6);
					out << right << info[tid].wkh_pvalue;
					if (info[tid].wkh_pvalue < 0.05)
						out << " - ";
					else
						out << " + ";
					out.width(6);
					out << right << info[tid].wsh_pvalue;
					if (info[tid].wsh_pvalue < 0.05)
						out << " - ";
					else
						out << " + ";
				}
				out.width(9);
				out << right << info[tid].elw_value;
				if (info[tid].elw_confident)
					out << " + ";
				else
					out << " - ";

                if (params.do_au_test) {
                    out.width(8);
                    out << right << info[tid].au_pvalue;
                    if (info[tid].au_pvalue < 0.05)
                        out << " - ";
                    else
                        out << " + ";
                }
                out.setf(ios::fixed);

                out << endl;
                tid++;
            }
            out << endl;

            if (params.topotest_replicates) {
                out <<  "deltaL  : logL difference from the maximal logl in the set." << endl
                     << "bp-RELL : bootstrap proportion using RELL method (Kishino et al. 1990)." << endl
                     << "p-KH    : p-value of one sided Kishino-Hasegawa test (1989)." << endl
                     << "p-SH    : p-value of Shimodaira-Hasegawa test (2000)." << endl;
                if (params.do_weighted_test) {
                    out << "p-WKH   : p-value of weighted KH test." << endl
                     << "p-WSH   : p-value of weighted SH test." << endl;
                }
                out     << "c-ELW   : Expected Likelihood Weight (Strimmer & Rambaut 2002)." << endl;
                if (params.do_au_test) {
                    out << "p-AU    : p-value of approximately unbiased (AU) test (Shimodaira, 2002)." << endl;
                }
                out  << endl
                     << "Plus signs denote the 95% confidence sets." << endl
                     << "Minus signs denote significant exclusion."  << endl
                     << "All tests performed "
                     << params.topotest_replicates << " resamplings using the RELL method."<<endl;
            }
            out << endl;
        }
        
        // export AliSim command if needed
        exportAliSimCMD(params, tree, out);

        time_t cur_time;
        time(&cur_time);

        char *date_str;
        date_str = ctime(&cur_time);
        out.unsetf(ios_base::fixed);
        out << "TIME STAMP" << endl << "----------" << endl << endl
                << "Date and time: " << date_str << "Total CPU time used: "
                << (double) params.run_time << " seconds (" << convert_time(params.run_time) << ")" << endl
                << "Total wall-clock time used: " << getRealTime() - params.start_real_time
                << " seconds (" << convert_time(getRealTime() - params.start_real_time) << ")" << endl << endl;

        //reportCredits(out); // not needed, now in the manual
        out.close();

        // for link-exchange-rates option
        // output the nexus file
        if (params.optimize_linked_gtr) {
            ModelSubst *mmodel = tree.getModel();
            ModelMarkov *m = (ModelMarkov*)mmodel->getMixtureClass(0);
            string outnexfile = params.out_prefix;
            outnexfile += ".GTRPMIX.nex";
            ofstream outnex;
            outnex.exceptions(ios::failbit | ios::badbit);
            outnex.open(outnexfile.c_str());
            reportNexusFile(outnex, m);
            outnex.close();
        }

    } catch (ios::failure) {
        outError(ERR_WRITE_OUTPUT, outfile);
    }
    
    printOutfilesInfo(params, tree);
}

void exportAliSimCMD(Params &params, IQTree &tree, ostream &out)
{
    // make sure this method will not make IQTREE crashed
    if (!(params.aln_file || params.partition_file) || !params.out_prefix || !tree.aln || !tree.getModel()
        || !(tree.aln->seq_type == SEQ_DNA || tree.aln->seq_type == SEQ_CODON || tree.aln->seq_type == SEQ_PROTEIN || tree.aln->seq_type == SEQ_BINARY || tree.aln->seq_type == SEQ_MORPH)
        || tree.isTreeMix())
        return;
    
    out << "ALISIM COMMAND" << endl;
    out << "--------------" << endl;
    
    string more_info = "For more information on using AliSim, please visit: www.iqtree.org/doc/AliSim";
    
    // skip unsupported models
    if (tree.getModel()->isMixture() || tree.getRate()->isHeterotachy() || tree.getModel()->isLieMarkov() || tree.aln->seq_type == SEQ_CODON)
    {
        out << "Currently, we only support exporting AliSim commands automatically from the analysis for common models of DNA, Protein, Binary, and Morphological data. To simulate data from other models (mixture, lie-markov, etc), please refer to the User Manual of AliSim. Thanks!" << endl << endl;
        out << more_info << endl << endl;
        return;
    }
    
    out << "To simulate an alignment of the same length as the original alignment, using the tree and model parameters estimated from this analysis, you can use the following command:" << endl << endl;
    
    // init alisim command
    string alisim_cmd = "--alisim simulated_MSA";
    
    // specify tree
    string tree_file(params.out_prefix);
    if (params.partition_file && params.partition_type == BRLEN_OPTIMIZE)
        tree_file += ".parttrees";
    else
        tree_file += ".treefile";
    alisim_cmd += " -t " + tree_file;
    
    // specify model or a partition file
    // if using partitions -> specify a partition file
    if (params.partition_file)
    {
        string partition_file(params.out_prefix);
        partition_file += ".best_model.nex";
        switch (params.partition_type)
        {
            case BRLEN_OPTIMIZE:
                alisim_cmd += " -Q " + partition_file;
                break;
            case BRLEN_FIX:
                alisim_cmd += " -q " + partition_file;
                break;
            case BRLEN_SCALE:
                alisim_cmd += " -p " + partition_file;
                break;
        }
    }
    // otherwise, specify a model
    else
    {
        string model_tr = tree.getModelNameParams(true);
        alisim_cmd += " -m \"" + model_tr + "\"";
        
        // specify num_states for morph data
        if (tree.aln->seq_type == SEQ_MORPH)
            alisim_cmd += " -st \"MORPH{" + convertIntToString(tree.aln->num_states) + "}\"";
    }
    
    // specify the length of root sequence
    // skip specifying sequence length for partitions
    if (!params.partition_file)
    {
        string root_length = "";
        int num_sites = tree.aln->getNSite() * (tree.aln->seq_type == SEQ_CODON ? 3 : 1);
        root_length += " --length " + convertIntToString(num_sites);
        alisim_cmd += root_length;
    }
    
    // output alisim cmd
    out << alisim_cmd << endl << endl;
    
    out << "To mimic the alignment used to produce this analysis, i.e. simulate an alignment of the same length as the original alignment, using the tree and model parameters estimated from this analysis *and* copying the same gap positions as the original alignment, you can use the following command:" << endl << endl;
    
    if (params.aln_file)
        out << "iqtree -s " << params.aln_file << " --alisim mimicked_MSA" << endl << endl;
    else
        out << "iqtree -s <alignment.phy> --alisim mimicked_MSA" << endl << endl;


    out << "To simulate any number of alignments in either of the two commandlines above, use the --num-alignments options, for example mimic 100 alignments you would use the command line:" << endl << endl;

    if (params.aln_file)
        out << "iqtree -s " << params.aln_file << " --alisim mimicked_MSA --num-alignments 100" << endl << endl;
    else
        out << "iqtree -s <alignment.phy> --alisim mimicked_MSA --num-alignments 100" << endl << endl;
    
    out << more_info << endl << endl;
}

void checkZeroDist(Alignment *aln, double *dist) {
    size_t ntaxa = aln->getNSeq();
    IntVector checked;
    checked.resize(ntaxa, 0);
    auto minLen = Params::getInstance().min_branch_length;
    for (size_t i = 0; i < ntaxa - 1; ++i) {
        if (checked[i])
            continue;
        string str = "";
        bool first = true;
        auto distRow = dist + i*ntaxa;
        for (size_t j = i + 1; j < ntaxa; ++j)
            if (distRow[j] <= minLen ) {
                if (first)
                    str = "ZERO distance between sequences "
                            + aln->getSeqName(i);
                str += ", " + aln->getSeqName(j);
                checked[j] = 1;
                first = false;
            }
        checked[i] = 1;
        if (str != "") {
            outWarning(str);
        }
    }
}


void printAnalysisInfo(int model_df, IQTree& iqtree, Params& params) {
//    if (!params.raxmllib) {
    cout << "Model of evolution: ";
    if (iqtree.isSuperTree() || iqtree.isTreeMix()) {
        cout << iqtree.getModelName() << " (" << model_df << " free parameters)" << endl;
    } else {
        cout << iqtree.getModelName() << " with ";
        switch (iqtree.getModel()->getFreqType()) {
        case FREQ_EQUAL:
            cout << "equal";
            break;
        case FREQ_EMPIRICAL:
            cout << "counted";
            break;
        case FREQ_USER_DEFINED:
            cout << "user-defined";
            break;
        case FREQ_ESTIMATE:
            cout << "optimized";
            break;
        case FREQ_CODON_1x4:
            cout << "counted 1x4";
            break;
        case FREQ_CODON_3x4:
            cout << "counted 3x4";
            break;
        case FREQ_CODON_3x4C:
            cout << "counted 3x4-corrected";
            break;
        case FREQ_DNA_RY:
            cout << "constrained A+G=C+T";
            break;
        case FREQ_DNA_WS:
            cout << "constrained A+T=C+G";
            break;
        case FREQ_DNA_MK:
            cout << "constrained A+C=G+T";
            break;
        case FREQ_DNA_1112:
            cout << "constrained A=C=G";
            break;
        case FREQ_DNA_1121:
            cout << "constrained A=C=T";
            break;
        case FREQ_DNA_1211:
            cout << "constrained A=G=T";
            break;
        case FREQ_DNA_2111:
            cout << "constrained C=G=T";
            break;
        case FREQ_DNA_1122:
            cout << "constrained A=C,G=T";
            break;
        case FREQ_DNA_1212:
            cout << "constrained A=G,C=T";
            break;
        case FREQ_DNA_1221:
            cout << "constrained A=T,C=G";
            break;
        case FREQ_DNA_1123:
            cout << "constrained A=C";
            break;
        case FREQ_DNA_1213:
            cout << "constrained A=G";
            break;
        case FREQ_DNA_1231:
            cout << "constrained A=T";
            break;
        case FREQ_DNA_2113:
            cout << "constrained C=G";
            break;
        case FREQ_DNA_2131:
            cout << "constrained C=T";
            break;
        case FREQ_DNA_2311:
            cout << "constrained G=T";
            break;
        default:
            outError("Wrong specified state frequencies");
        }
        cout << " frequencies (" << model_df << " free parameters)" << endl;
    }
    cout << "Fixed branch lengths: "
            << ((params.fixed_branch_length) ? "Yes" : "No") << endl;

    if (params.min_iterations > 0) {
        cout << "Tree search algorithm: " << (params.snni ? "Stochastic nearest neighbor interchange" : "IQPNNI") << endl;
        cout << "Termination condition: ";
        if (params.stop_condition == SC_REAL_TIME) {
            cout << "after " << params.maxtime << " minutes" << endl;
        } else if (params.stop_condition == SC_UNSUCCESS_ITERATION) {
            cout << "after " << params.unsuccess_iteration << " unsuccessful iterations" << endl;
        } else if (params.stop_condition == SC_FIXED_ITERATION) {
                cout << params.min_iterations << " iterations" << endl;
        } else if(params.stop_condition == SC_WEIBULL) {
                cout << "predicted in [" << params.min_iterations << ","
                        << params.max_iterations << "] (confidence "
                        << params.stop_confidence << ")" << endl;
        } else if (params.stop_condition == SC_BOOTSTRAP_CORRELATION) {
            cout << "min " << params.min_correlation << " correlation coefficient" << endl;
        }

        if (!params.snni) {
            cout << "Number of representative leaves  : " << params.k_representative << endl;
            cout << "Probability of deleting sequences: " << iqtree.getProbDelete() << endl;
            cout << "Number of leaves to be deleted   : " << iqtree.getDelete() << endl;
            cout << "Important quartets assessed on: "
                    << ((params.iqp_assess_quartet == IQP_DISTANCE) ?
                            "Distance" : ((params.iqp_assess_quartet == IQP_PARSIMONY) ? "Parsimony" : "Bootstrap"))
                    << endl;
        }
        cout << "NNI assessed on: " << ((params.nni5) ? "5 branches" : "1 branch") << endl;
    }
    cout << "Phylogenetic likelihood library: " << (params.pll ? "Yes" : "No") << endl;
    if (params.fixed_branch_length != BRLEN_FIX)
        cout << "Branch length optimization method: "
            << ((iqtree.optimize_by_newton) ? "Newton" : "Brent") << endl;
    cout << "Number of Newton-Raphson steps in NNI evaluation and branch length optimization: " << NNI_MAX_NR_STEP
            << " / " << PLL_NEWZPERCYCLE << endl;
    cout << "SSE instructions: "
            << ((iqtree.sse) ? "Yes" : "No") << endl;
    cout << endl;
}

void computeMLDist ( Params& params, IQTree& iqtree
                   , double begin_wallclock_time, double begin_cpu_time) {
    double longest_dist;
    cout << "Computing ML distances based on estimated model parameters..." << endl;
    double *ml_dist = nullptr;
    double *ml_var  = nullptr;
    iqtree.decideDistanceFilePath(params);
    longest_dist = iqtree.computeDist(params, iqtree.aln, ml_dist, ml_var);
    cout << "Computing ML distances took "
        << (getRealTime() - begin_wallclock_time) << " sec (of wall-clock time) "
        << (getCPUTime() - begin_cpu_time) << " sec (of CPU time)" << endl;
    size_t n = iqtree.aln->getNSeq();
    size_t nSquared = n*n;
    if ( iqtree.dist_matrix == nullptr ) {
        iqtree.dist_matrix = ml_dist;
        ml_dist = nullptr;
    } else {
        memmove(iqtree.dist_matrix, ml_dist,
                sizeof(double) * nSquared);
        delete[] ml_dist;
    }
    if ( iqtree.var_matrix == nullptr ) {
        iqtree.var_matrix = ml_var;
        ml_var = nullptr;
    } else {
        memmove(iqtree.var_matrix, ml_var,
                sizeof(double) * nSquared);
        delete[] ml_var;
    }
    if (!params.dist_file)
    {
        iqtree.printDistanceFile();
    }
    double max_genetic_dist = MAX_GENETIC_DIST;
    if (iqtree.aln->seq_type == SEQ_POMO) {
        int N = iqtree.aln->virtual_pop_size;
        max_genetic_dist *= N * N;
    }
    if (longest_dist > max_genetic_dist * 0.99) {
        outWarning("Some pairwise ML distances are too long (saturated)");
    }
}

void computeInitialDist(Params &params, IQTree &iqtree) {
    double longest_dist;
    if (params.dist_file) {
        cout << "Reading distance matrix file " << params.dist_file << " ..." << endl;
    } else if (params.compute_jc_dist) {
        cout << "Computing Jukes-Cantor distances..." << endl;
    } else if (params.compute_obs_dist) {
        cout << "Computing observed distances..." << endl;
    }

    if (params.compute_jc_dist || params.compute_obs_dist || params.partition_file) {
        longest_dist = iqtree.computeDist(params, iqtree.aln, iqtree.dist_matrix, iqtree.var_matrix);
        //if (!params.suppress_zero_distance_warnings) {
        //  checkZeroDist(iqtree.aln, iqtree.dist_matrix);
        //}
        double max_genetic_dist = MAX_GENETIC_DIST;
        if (iqtree.aln->seq_type == SEQ_POMO) {
            int N = iqtree.aln->virtual_pop_size;
            max_genetic_dist *= N * N;
        }
        if (longest_dist > max_genetic_dist * 0.99) {
            outWarning("Some pairwise distances are too long (saturated)");
        }
    }
}

void initializeParams(Params &params, IQTree &iqtree)
{
//    iqtree.setCurScore(-DBL_MAX);
    bool ok_tree = iqtree.root;
    if (iqtree.isSuperTreeUnlinked())
        ok_tree = ((PhyloSuperTree*)&iqtree)->front()->root;
    if (!ok_tree)
    {
        // compute initial tree
        if (!params.compute_ml_tree_only) {
            if (iqtree.isTreeMix())
                ((IQTreeMix*) &iqtree)->computeInitialTree(params.SSE);
            else
                iqtree.computeInitialTree(params.SSE);
        }
    }
    ASSERT(iqtree.aln);

    if (iqtree.aln->model_name == "WHTEST") {
        if (iqtree.aln->seq_type != SEQ_DNA)
            outError("Weiss & von Haeseler test of model homogeneity only works for DNA");
        iqtree.aln->model_name = "GTR+G";
    }
    if (params.gbo_replicates)
    {
        params.speed_conf = 1.0;
    }

    // TODO: check if necessary
//    if (iqtree.isSuperTree())
//        ((PhyloSuperTree*) &iqtree)->mapTrees();

    // set parameter for the current tree
//    iqtree.setParams(params);
}

void pruneTaxa(Params &params, IQTree &iqtree, double *pattern_lh, NodeVector &pruned_taxa, StrVector &linked_name) {
    int num_low_support;
    double mytime;

    if (params.aLRT_threshold <= 100 && (params.aLRT_replicates > 0 || params.localbp_replicates > 0)) {
        mytime = getCPUTime();
        cout << "Testing tree branches by SH-like aLRT with " << params.aLRT_replicates << " replicates..." << endl;
        iqtree.setRootNode(params.root);
        double curScore =  iqtree.getCurScore();
        iqtree.computePatternLikelihood(pattern_lh, &curScore);
        num_low_support = iqtree.testAllBranches(params.aLRT_threshold, curScore,
                pattern_lh, params.aLRT_replicates, params.localbp_replicates, params.aLRT_test, params.aBayes_test);
        iqtree.printResultTree();
        cout << "  " << getCPUTime() - mytime << " sec." << endl;
        cout << num_low_support << " branches show low support values (<= " << params.aLRT_threshold << "%)" << endl;

        //tree.drawTree(cout);
        cout << "Collapsing stable clades..." << endl;
        iqtree.collapseStableClade(params.aLRT_threshold, pruned_taxa, linked_name, iqtree.dist_matrix);
        cout << pruned_taxa.size() << " taxa were pruned from stable clades" << endl;
    }

    if (!pruned_taxa.empty()) {
        cout << "Pruned alignment contains " << iqtree.aln->getNSeq()
                << " sequences and " << iqtree.aln->getNSite() << " sites and "
                << iqtree.aln->getNPattern() << " patterns" << endl;
        iqtree.initializeAllPartialLh();
        iqtree.clearAllPartialLH();
        iqtree.setCurScore(iqtree.optimizeAllBranches());
        //cout << "Log-likelihood    after reoptimizing model parameters: " << tree.curScore << endl;
        iqtree.optimizeNNI();
        cout << "Log-likelihood after optimizing partial tree: "
                << iqtree.getCurScore() << endl;
    }

}

void restoreTaxa(IQTree &iqtree, double *saved_dist_mat, NodeVector &pruned_taxa, StrVector &linked_name) {
    if (!pruned_taxa.empty()) {
        cout << "Restoring full tree..." << endl;
        iqtree.restoreStableClade(iqtree.aln, pruned_taxa, linked_name);
        delete[] iqtree.dist_matrix;
        iqtree.dist_matrix = saved_dist_mat;
        iqtree.initializeAllPartialLh();
        iqtree.clearAllPartialLH();
        iqtree.setCurScore(iqtree.optimizeAllBranches());
        //cout << "Log-likelihood    after reoptimizing model parameters: " << tree.curScore << endl;
        pair<int, int> nniInfo;
        nniInfo = iqtree.optimizeNNI();
        cout << "Log-likelihood    after reoptimizing full tree: " << iqtree.getCurScore() << endl;
        //iqtree.setBestScore(iqtree.getModelFactory()->optimizeParameters(params.fixed_branch_length, true, params.model_eps));

    }
}
void runApproximateBranchLengths(Params &params, IQTree &iqtree) {
    if (!params.fixed_branch_length && params.leastSquareBranch) {
        cout << endl << "Computing Least Square branch lengths..." << endl;
        iqtree.optimizeAllBranchesLS();
        iqtree.clearAllPartialLH();
        iqtree.setCurScore(iqtree.computeLikelihood());
        string filename = params.out_prefix;
        filename += ".lstree";
        iqtree.printTree(filename.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA | WT_NEWLINE);
        cout << "Logl of tree with LS branch lengths: " << iqtree.getCurScore() << endl;
        cout << "Tree with LS branch lengths written to " << filename << endl;
        if (params.print_branch_lengths) {
            if (params.manuel_analytic_approx) {
                cout << "Applying Manuel's analytic approximation.." << endl;
                iqtree.approxAllBranches();
            }
            ofstream out;
            filename = params.out_prefix;
            filename += ".lsbrlen";
            out.open(filename.c_str());
            iqtree.printBranchLengths(out);
            out.close();
            cout << "LS Branch lengths written to " << filename << endl;
        }
        cout << "Total LS tree length: " << iqtree.treeLength() << endl;
    }

    if (params.pars_branch_length) {
        cout << endl << "Computing parsimony branch lengths..." << endl;
        iqtree.fixNegativeBranch(true);
        iqtree.clearAllPartialLH();
        iqtree.setCurScore(iqtree.computeLikelihood());
        string filename = params.out_prefix;
        filename += ".mptree";
        iqtree.printTree(filename.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA | WT_NEWLINE);
        cout << "Logl of tree with MP branch lengths: " << iqtree.getCurScore() << endl;
        cout << "Tree with MP branch lengths written to " << filename << endl;
        if (params.print_branch_lengths) {
            ofstream out;
            filename = params.out_prefix;
            filename += ".mpbrlen";
            out.open(filename.c_str());
            iqtree.printBranchLengths(out);
            out.close();
            cout << "MP Branch lengths written to " << filename << endl;
        }
        cout << "Total MP tree length: " << iqtree.treeLength() << endl;

    }

    if (params.bayes_branch_length) {
        cout << endl << "Computing Bayesian branch lengths..." << endl;
        iqtree.computeAllBayesianBranchLengths();
        iqtree.clearAllPartialLH();
        iqtree.setCurScore(iqtree.computeLikelihood());
        string filename = params.out_prefix;
        filename += ".batree";
        iqtree.printTree(filename.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA | WT_NEWLINE);
        cout << "Logl of tree with Bayesian branch lengths: " << iqtree.getCurScore() << endl;
        cout << "Tree with Bayesian branch lengths written to " << filename << endl;
        if (params.print_branch_lengths) {
            ofstream out;
            filename = params.out_prefix;
            filename += ".babrlen";
            out.open(filename.c_str());
            iqtree.printBranchLengths(out);
            out.close();
            cout << "Bayesian Branch lengths written to " << filename << endl;
        }
        cout << "Total Bayesian tree length: " << iqtree.treeLength() << endl;

    }

}

void printSiteRates(IQTree &iqtree, const char *rate_file, bool bayes) {
    try {
        ofstream out;
        out.exceptions(ios::failbit | ios::badbit);
        out.open(rate_file);
        out << "# Site-specific subtitution rates determined by ";
        if (bayes)
            out<< "empirical Bayesian method" << endl;
        else
            out<< "maximum likelihood" << endl;
        out << "# This file can be read in MS Excel or in R with command:" << endl
        << "#   tab=read.table('" <<  rate_file << "',header=TRUE)" << endl
        << "# Columns are tab-separated with following meaning:" << endl;
        if (iqtree.isSuperTree()) {
            out << "#   Part:   Partition ID (1=" << ((PhyloSuperTree*)&iqtree)->front()->aln->name << ", etc)" << endl
            << "#   Site:   Site ID within partition (starting from 1 for each partition)" << endl;
        } else
            out << "#   Site:   Alignment site ID" << endl;
        
        if (bayes)
            out << "#   Rate:   Posterior mean site rate weighted by posterior probability" << endl
                << "#   Cat:    Category with highest posterior (0=invariable, 1=slow, etc)" << endl
                << "#   C_Rate: Corresponding rate of highest category" << endl;
        else
            out << "#   Rate:   Site rate estimated by maximum likelihood" << endl;
        if (iqtree.isSuperTree())
            out << "Part\t";
        out << "Site\tRate";
        if (bayes)
            out << "\tCat\tC_Rate" << endl;
        else
            out << endl;
        iqtree.writeSiteRates(out, bayes);
        out.close();
    } catch (ios::failure) {
        outError(ERR_WRITE_OUTPUT, rate_file);
    }
    cout << "Site rates printed to " << rate_file << endl;
}

void printMiscInfo(Params &params, IQTree &iqtree, double *pattern_lh) {
    if (params.print_site_lh && !params.pll) {
        string site_lh_file = params.out_prefix;
        site_lh_file += ".sitelh";
        if (params.print_site_lh == WSL_SITE)
            printSiteLh(site_lh_file.c_str(), &iqtree, pattern_lh);
        else
            printSiteLhCategory(site_lh_file.c_str(), &iqtree, params.print_site_lh);
    }
    
    if (params.optimize_params_use_hmm){
        string hmm_file = string(params.out_prefix) + ".hmm";
        int cat_assign_method = 0;
        // the categories along sites is assigned according to the path with maximum probability (default)
        printHMMResult(hmm_file.c_str(), &iqtree, cat_assign_method);

        hmm_file = string(params.out_prefix) + ".pp.hmm";
        cat_assign_method = 1;
        // the categories along sites is assigned according to the max posterior probability
        printHMMResult(hmm_file.c_str(), &iqtree, cat_assign_method);

        if (params.print_marginal_prob) {
            string mp_file = params.out_prefix;
            mp_file += ".mprob";
            printMarginalProb(mp_file.c_str(), &iqtree);
        }
    }
    
    if (params.print_partition_lh && !iqtree.isSuperTree()) {
        outWarning("-wpl does not work with non-partition model");
        params.print_partition_lh = false;
    }
    if (params.print_partition_lh && !params.pll) {
        string part_lh_file = (string)params.out_prefix + ".partlh";
        printPartitionLh(part_lh_file.c_str(), &iqtree, pattern_lh);
    }

    if (params.print_site_prob && !params.pll) {
        printSiteProbCategory(((string)params.out_prefix + ".siteprob").c_str(), &iqtree, params.print_site_prob);
    }
    
    if (params.print_ancestral_sequence) {
        printAncestralSequences(params.out_prefix, &iqtree, params.print_ancestral_sequence);
    }
    
    if (params.print_site_state_freq != WSF_NONE && !params.site_freq_file && !params.tree_freq_file) {
        string site_freq_file = params.out_prefix;
        site_freq_file += ".sitesf";
        printSiteStateFreq(site_freq_file.c_str(), &iqtree);
    }

    if (params.print_trees_site_posterior) {
        cout << "Computing mixture posterior probabilities" << endl;
        IntVector pattern_cat;
        int num_mix = iqtree.computePatternCategories(&pattern_cat);
        cout << num_mix << " mixture components are necessary" << endl;
        string site_mix_file = (string)params.out_prefix + ".sitemix";
        ofstream out(site_mix_file.c_str());
        if (!out.is_open())
            outError("File " + site_mix_file + " could not be opened");
        out << "Ptn\tFreq\tNumMix" << endl;
        int ptn;
        for (ptn = 0; ptn < pattern_cat.size(); ptn++)
            out << ptn << "\t" << (int)iqtree.ptn_freq[ptn] << "\t" << pattern_cat[ptn] << endl;
        out.close();
        cout << "Pattern mixtures printed to " << site_mix_file << endl;

        site_mix_file = (string)params.out_prefix + ".sitemixall";
        out.open(site_mix_file.c_str());
        int ncat = iqtree.getRate()->getNRate();
        if (iqtree.getModel()->isMixture() && !iqtree.getModelFactory()->fused_mix_rate)
            ncat = iqtree.getModel()->getNMixtures();
        out << "Ptn\tFreq\tNumMix\tCat" << endl;

        int c;
        for (ptn = 0; ptn < iqtree.ptn_cat_mask.size(); ptn++) {
            int num_cat = popcount_lauradoux((unsigned*)&iqtree.ptn_cat_mask[ptn], 2);
            out << ptn << "\t" << (int)iqtree.ptn_freq[ptn] << "\t" << num_cat << "\t";
            for (c = 0; c < ncat; c++)
                if (iqtree.ptn_cat_mask[ptn] & ((uint64_t)1<<c))
                    out << "1";
                else
                    out << "0";
            out << endl;
        }
        out.close();
    }

    if (params.print_branch_lengths) {
        if (params.manuel_analytic_approx) {
            cout << "Applying Manuel's analytic approximation.." << endl;
            iqtree.approxAllBranches();
        }
        string brlen_file = params.out_prefix;
        brlen_file += ".brlen";
        ofstream out;
        out.open(brlen_file.c_str());
        iqtree.printBranchLengths(out);
        out.close();
        cout << "Branch lengths written to " << brlen_file << endl;
    }

    if (params.write_branches) {
        string filename = string(params.out_prefix) + ".branches.csv";
        ofstream out;
        out.open(filename.c_str());
        iqtree.writeBranches(out);
        out.close();
        cout << "Branch lengths written to " << filename << endl;
    }
    
    if (params.print_conaln && iqtree.isSuperTree()) {
        string str = params.out_prefix;
        str = params.out_prefix;
        str += ".conaln";
        iqtree.aln->printAlignment(params.aln_output_format, str.c_str());
    }
    
    if (params.print_partition_info && iqtree.isSuperTree()) {
        ASSERT(params.print_conaln);
        string aln_file = (string)params.out_prefix + ".conaln";
        string partition_info = params.out_prefix;
        partition_info += ".partinfo.nex";
        ((SuperAlignment*)(iqtree.aln))->printPartition(partition_info.c_str(), aln_file.c_str());
        partition_info = (string)params.out_prefix + ".partitions";
        ((SuperAlignment*)(iqtree.aln))->printPartitionRaxml(partition_info.c_str());
    }

    if (params.mvh_site_rate) {
        RateMeyerHaeseler *rate_mvh = new RateMeyerHaeseler(params.rate_file,
                &iqtree, params.rate_mh_type);
        cout << endl << "Computing site-specific rates by "
                << rate_mvh->full_name << "..." << endl;
        rate_mvh->runIterativeProc(params, iqtree);
        cout << endl << "BEST SCORE FOUND : " << iqtree.getBestScore()<< endl;
        string mhrate_file = params.out_prefix;
        mhrate_file += ".mhrate";
        try {
            ofstream out;
            out.exceptions(ios::failbit | ios::badbit);
            out.open(mhrate_file.c_str());
            iqtree.writeSiteRates(out, true);
            out.close();
        } catch (ios::failure) {
            outError(ERR_WRITE_OUTPUT, mhrate_file);
        }

        if (params.print_site_lh) {
            string site_lh_file = params.out_prefix;
            site_lh_file += ".mhsitelh";
            printSiteLh(site_lh_file.c_str(), &iqtree);
        }
    }

    if (params.print_site_rate & 1) {
        string rate_file = params.out_prefix;
        rate_file += ".rate";
        printSiteRates(iqtree, rate_file.c_str(), true);
    }

    if (params.print_site_rate & 2) {
        string rate_file = params.out_prefix;
        rate_file += ".mlrate";
        printSiteRates(iqtree, rate_file.c_str(), false);
    }

    if (params.fixed_branch_length == BRLEN_SCALE) {
        string filename = (string)params.out_prefix + ".blscale";
        iqtree.printTreeLengthScaling(filename.c_str());
        cout << "Scaled tree length and model parameters printed to " << filename << endl;
    }

}

void printFinalSearchInfo(Params &params, IQTree &iqtree, double search_cpu_time, double search_real_time) {
    
    if (iqtree.isTreeMix()) {
        cout << "Total tree lengths:";
        IQTreeMix* treemix = (IQTreeMix*) &iqtree;
        for (size_t i = 0; i < treemix->size(); i++) {
            cout << " " << treemix->at(i)->treeLength();
        }
        cout << endl;
    } else {
        cout << "Total tree length: " << iqtree.treeLength() << endl;
    }

    if (iqtree.isSuperTree() && verbose_mode >= VB_MAX) {
        PhyloSuperTree *stree = (PhyloSuperTree*) &iqtree;
        cout << stree->evalNNIs << " NNIs evaluated from " << stree->totalNNIs << " all possible NNIs ( " <<
                (int)(((stree->evalNNIs+1.0)/(stree->totalNNIs+1.0))*100.0) << " %)" << endl;
        cout<<"Details for subtrees:"<<endl;
        int part = 0;
        for(auto it = stree->begin(); it != stree->end(); it++,part++){
            cout << part+1 << ". " << (*it)->aln->name << ": " << stree->part_info[part].evalNNIs<<" ( "
                << (int)(((stree->part_info[part].evalNNIs+1.0)/((stree->totalNNIs+1.0) / stree->size()))*100.0)
                << " %)" << endl;
        }
    }

    params.run_time = (getCPUTime() - params.startCPUTime);
    cout << endl;
    cout << "Total number of iterations: " << iqtree.stop_rule.getCurIt() << endl;
//    cout << "Total number of partial likelihood vector computations: " << iqtree.num_partial_lh_computations << endl;
    cout << "CPU time used for tree search: " << search_cpu_time
            << " sec (" << convert_time(search_cpu_time) << ")" << endl;
    cout << "Wall-clock time used for tree search: " << search_real_time
            << " sec (" << convert_time(search_real_time) << ")" << endl;
    cout << "Total CPU time used: " << (double) params.run_time << " sec ("
            << convert_time((double) params.run_time) << ")" << endl;
    cout << "Total wall-clock time used: "
            << getRealTime() - params.start_real_time << " sec ("
            << convert_time(getRealTime() - params.start_real_time) << ")" << endl;

}

void printTrees(vector<string> trees, Params &params, string suffix) {
    ofstream treesOut((string(params.out_prefix) + suffix).c_str(),
            ofstream::out);
    for (vector<string>::iterator it = trees.begin(); it != trees.end(); it++) {
        treesOut << (*it);
        treesOut << endl;
    }
    treesOut.close();
}

/************************************************************
 *  MAIN TREE RECONSTRUCTION
 ***********************************************************/

void startTreeReconstruction(Params &params, IQTree* &iqtree, ModelCheckpoint &model_info) {
    if (params.root) {
        StrVector outgroup_names;
        convert_string_vec(params.root, outgroup_names);
        for (auto it = outgroup_names.begin(); it != outgroup_names.end(); it++)
            if (iqtree->aln->getSeqID(*it) < 0)
                outError("Alignment does not have specified outgroup taxon ", *it);
    }

//    if (params.count_trees && pllTreeCounter == NULL)
//        pllTreeCounter = new StringIntMap;

    // Temporary fix since PLL only supports DNA/Protein: switch to IQ-TREE parsimony kernel
    if (params.start_tree == STT_PLL_PARSIMONY) {
        if (iqtree->isSuperTreeUnlinked()) {
            params.start_tree = STT_PARSIMONY;
        } else if (iqtree->isSuperTree()) {
            PhyloSuperTree *stree = (PhyloSuperTree*)iqtree;
            for (PhyloSuperTree::iterator it = stree->begin(); it != stree->end(); it++)
                if ((*it)->aln->seq_type != SEQ_DNA && (*it)->aln->seq_type != SEQ_PROTEIN)
                    params.start_tree = STT_PARSIMONY;
        } else if (iqtree->aln->seq_type != SEQ_DNA && iqtree->aln->seq_type != SEQ_PROTEIN)
            params.start_tree = STT_PARSIMONY;
    }

    /***************** Initialization for PLL and sNNI ******************/
    if (params.start_tree == STT_PLL_PARSIMONY || params.start_tree == STT_RANDOM_TREE || params.pll) {
        /* Initialized all data structure for PLL*/
        iqtree->initializePLL(params);
    }
    
    /********************* Compute pairwise distances *******************/
    if (params.start_tree == STT_BIONJ || params.iqp || params.leastSquareBranch) {
        computeInitialDist(params, *iqtree);
    }
    
    /******************** Pass the parameter object params to IQTree *******************/
    iqtree->setParams(&params);

    /*************** SET UP PARAMETERS and model testing ****************/

       // FOR TUNG: swapping the order cause bug for -m TESTLINK
//    iqtree.initSettings(params);

    params.startCPUTime = getCPUTime();
    params.start_real_time = getRealTime();

    string best_subst_name, best_rate_name;
    runModelFinder(params, *iqtree, model_info, best_subst_name, best_rate_name);
    
    optimiseQMixModel(params, iqtree, model_info);
}
        
/**
 optimize branch lengths of consensus tree
 */
void optimizeConTree(Params &params, IQTree *tree) {
    string contree_file = string(params.out_prefix) + ".contree";
    
    DoubleVector rfdist;
    tree->computeRFDist(contree_file.c_str(), rfdist);
    tree->contree_rfdist = (int)rfdist[0];
    
    tree->readTreeFile(contree_file);
    
    tree->initializeAllPartialLh();
    tree->fixNegativeBranch(false);
    
    tree->boot_consense_logl = tree->optimizeAllBranches();
    cout << "Log-likelihood of consensus tree: " << tree->boot_consense_logl << endl;
    tree->setRootNode(params.root);
    tree->insertTaxa(tree->removed_seqs, tree->twin_seqs);
    tree->printTree(contree_file.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA | WT_NEWLINE);
    string contree = tree->getTreeString();
    tree->getCheckpoint()->put("contree", contree);
}

// check whether it is tree-mixture model
bool isTreeMixture(Params& params) {
    return (params.model_name.find("+T") != string::npos);
}

// get the number after "+T" for tree-mixture model
int getTreeMixNum(Params& params) {
    int n = 0;
    size_t p = params.model_name.find("+T");
    string str_n;
    if (p != string::npos && p < params.model_name.length()-2) {
        str_n = params.model_name.substr(p+2);
        n = atoi(str_n.c_str());
    }
    return n;
}

void runTreeReconstruction(Params &params, IQTree* &iqtree) {

    //    string dist_file;
    // params.startCPUTime = getCPUTime();
    // params.start_real_time = getRealTime();
    
    int absent_states = 0;
    if (iqtree->isSuperTree()) {
        PhyloSuperTree *stree = (PhyloSuperTree*)iqtree;
        for (auto i = stree->begin(); i != stree->end(); i++)
            absent_states += (*i)->aln->checkAbsentStates("partition " + (*i)->aln->name);
    } else {
        absent_states = iqtree->aln->checkAbsentStates("alignment");
    }
    if (absent_states > 0) {
        cout << "NOTE: " << absent_states << " states (see above) are not present and thus removed from Markov process to prevent numerical problems" << endl;
    }
    
    // Make sure that no partial likelihood of IQ-TREE is initialized when PLL is used to save memory
    if (params.pll) {
        iqtree->deleteAllPartialLh();
    }
    
    /***************** Initialization for PLL and sNNI ******************/
    if ((params.start_tree == STT_PLL_PARSIMONY || params.start_tree == STT_RANDOM_TREE || params.pll) && !iqtree->isInitializedPLL()) {
        /* Initialized all data structure for PLL*/
        iqtree->initializePLL(params);
    }
    
    
    /********************* Compute pairwise distances *******************/
    if ((params.start_tree == STT_BIONJ || params.iqp || params.leastSquareBranch) && !iqtree->root) {
        computeInitialDist(params, *iqtree);
    }
    
    /******************** Pass the parameter object params to IQTree *******************/
    iqtree->setParams(&params);
    
    ModelsBlock *models_block = readModelsDefinition(params);

    initializeParams(params, *iqtree);

    if (posRateHeterotachy(iqtree->aln->model_name) != string::npos && !iqtree->isMixlen()) {
        // rate mixture
        
        if (iqtree->isTreeMix()) {
            outError("Tree-mixture model does not work with rate mixture");
        }
        
        // create a new instance
        IQTree* iqtree_new = new PhyloTreeMixlen(iqtree->aln, 0);
        iqtree_new->setCheckpoint(iqtree->getCheckpoint());
        if (!iqtree->constraintTree.empty())
            iqtree_new->constraintTree.readConstraint(iqtree->constraintTree);
        iqtree_new->removed_seqs = iqtree->removed_seqs;
        iqtree_new->twin_seqs = iqtree->twin_seqs;
        if (params.start_tree == STT_PLL_PARSIMONY || params.start_tree == STT_RANDOM_TREE || params.pll) {
            /* Initialized all data structure for PLL*/
            iqtree_new->initializePLL(params);
        }
        iqtree_new->setParams(&params);
        iqtree_new->copyPhyloTree(iqtree, false);

        // replace iqtree object
        delete iqtree;
        iqtree = iqtree_new;
    }

    if (!params.compute_ml_tree_only) {
        iqtree->setRootNode(params.root);
    }

    iqtree->restoreCheckpoint();

    if (params.online_bootstrap && params.gbo_replicates > 0) {
        cout << "Generating " << params.gbo_replicates << " samples for ultrafast "
        << RESAMPLE_NAME << " (seed: " << params.ran_seed << ")..." << endl;
    }

    iqtree->initSettings(params);

    /*********************** INITIAL MODEL OPTIMIZATION *****************/


    if (!iqtree->getModelFactory()) {
        iqtree->initializeModel(params, iqtree->aln->model_name, models_block);
    }
    if (iqtree->getRate()->isHeterotachy() && !iqtree->isMixlen()) {
        ASSERT(0 && "Heterotachy tree not properly created");
    }
//    iqtree.restoreCheckpoint();

    delete models_block;

    // UpperBounds analysis. Here, to analyse the initial tree without any tree search or optimization
    /*
    if (params.upper_bound) {
        iqtree.setCurScore(iqtree.computeLikelihood());
        cout<<iqtree.getCurScore()<<endl;
        UpperBounds(&params, iqtree.aln, iqtree);
        exit(0);
    }
    */

    // degree of freedom
    cout << endl;
    if (verbose_mode >= VB_MED) {
        cout << "ML-TREE SEARCH START WITH THE FOLLOWING PARAMETERS:" << endl;
        int model_df;
        if (iqtree->isTreeMix()) {
            model_df = ((IQTreeMix*) iqtree)->getNParameters();
        } else {
            model_df = iqtree->getModelFactory()->getNParameters(BRLEN_OPTIMIZE);
        }
        printAnalysisInfo(model_df, *iqtree, params);
    }

    if (!params.pll) {
        uint64_t total_mem = getMemorySize();
        if (params.lh_mem_save == LM_MEM_SAVE && params.max_mem_size > total_mem)
            params.max_mem_size = total_mem;

        uint64_t mem_required = iqtree->getMemoryRequired();

        if (mem_required >= total_mem*0.95 && !iqtree->isSuperTree()) {
            // switch to memory saving mode
            if (params.lh_mem_save != LM_MEM_SAVE) {
                params.max_mem_size = (total_mem*0.95)/mem_required;
                params.lh_mem_save = LM_MEM_SAVE;
                mem_required = iqtree->getMemoryRequired();
                cout << "NOTE: Switching to memory saving mode using " << (mem_required / 1073741824.0) << " GB ("
                    <<  (mem_required*100/total_mem) << "% of normal mode)" << endl;
                cout << "NOTE: Use -mem option if you want to restrict RAM usage further" << endl;
            }
            if (mem_required >= total_mem) {
                params.lh_mem_save = LM_MEM_SAVE;
                params.max_mem_size = 0.0;
                mem_required = iqtree->getMemoryRequired();
            }
        }
        if (mem_required >= total_mem) {
            cerr << "ERROR: Your RAM is below minimum requirement of " << (mem_required / 1073741824.0) << " GB RAM" << endl;
            outError("Memory saving mode cannot work, switch to another computer!!!");
        }

//#if defined __APPLE__ || defined __MACH__
        cout << "NOTE: " << (mem_required / 1048576) << " MB RAM (" << (mem_required / 1073741824) << " GB) is required!" << endl;
//#else
//        cout << "NOTE: " << ((double) mem_size / 1000.0) / 1000 << " MB RAM is required!" << endl;
//#endif
        if (params.memCheck)
            exit(0);
#ifdef BINARY32
        if (mem_required >= 2000000000) {
            outError("Memory required exceeds 2GB limit of 32-bit executable");
        }
#endif
        int max_procs = countPhysicalCPUCores();
        if (mem_required * max_procs > total_mem * iqtree->num_threads && iqtree->num_threads > 0) {
            outWarning("Memory required per CPU-core (" + convertDoubleToString((double)mem_required/iqtree->num_threads/1024/1024/1024)+
            " GB) is higher than your computer RAM per CPU-core ("+convertIntToString(total_mem/max_procs/1024/1024/1024)+
            " GB), thus multiple runs may exceed RAM!");
        }
    }

    bool   finishedInitTree = false;
    double initEpsilon = params.min_iterations == 0 ? params.modelEps : (params.modelEps*10);
    if (iqtree->isTreeMix()) {
        if (iqtree->isHMM())
            initEpsilon = params.treemixhmm_eps;
        else
            initEpsilon = params.treemix_eps;
    }
    string initTree;
    
    //None of his will work until there is actually a tree
    //(we cannot do it until we *have* one).
    if (!params.compute_ml_tree_only) {
        
        iqtree->ensureNumberOfThreadsIsSet(&params);

        iqtree->initializeAllPartialLh();

        if (iqtree->getRate()->name.find("+I+G") != string::npos) {
            if (params.alpha_invar_file != NULL) { // COMPUTE TREE LIKELIHOOD BASED ON THE INPUT ALPHA AND P_INVAR VALUE
                computeLoglFromUserInputGAMMAInvar(params, *iqtree);
                exit(0);
            }
            if (params.exh_ai) {
                exhaustiveSearchGAMMAInvar(params, *iqtree);
                exit(0);
            }
        }
        
        // Optimize model parameters and branch lengths using ML for the initial tree
        iqtree->clearAllPartialLH();
        initTree = iqtree->ensureModelParametersAreSet(initEpsilon);
        
        if (params.lmap_num_quartets >= 0) {
            cout << endl << "Performing likelihood mapping with ";
            if (params.lmap_num_quartets > 0)
                cout << params.lmap_num_quartets;
            else
                cout << "all";
            cout << " quartets..." << endl;
            double lkmap_time = getRealTime();
            iqtree->doLikelihoodMapping();
            cout << "Likelihood mapping needed " << getRealTime()-lkmap_time << " seconds" << endl << endl;
        }
        finishedInitTree = iqtree->getCheckpoint()->getBool("finishedInitTree");
        
        // now overwrite with random tree
        if (params.start_tree == STT_RANDOM_TREE && !finishedInitTree) {
            if (params.tree_gen != NONE)
            {
                iqtree->generateRandomTree(params.tree_gen);
            }
            else
            {
                cout << "Generate random initial Yule-Harding tree..." << endl;
                iqtree->generateRandomTree(YULE_HARDING);
            }
            iqtree->wrapperFixNegativeBranch(true);
            iqtree->initializeAllPartialLh();
            initTree = iqtree->optimizeBranches(params.brlen_num_traversal);
            cout << "Log-likelihood of random tree: " << iqtree->getCurScore() << endl;
        }
        /****************** NOW PERFORM MAXIMUM LIKELIHOOD TREE RECONSTRUCTION ******************/
        
        // Update best tree
        if (!finishedInitTree) {
            iqtree->addTreeToCandidateSet(initTree, iqtree->getCurScore(), false, MPIHelper::getInstance().getProcessID());
            iqtree->printResultTree();
            iqtree->intermediateTrees.update(iqtree->getTreeString(), iqtree->getCurScore());
            if (iqtree->isSuperTreeUnlinked()) {
                PhyloSuperTree* stree = (PhyloSuperTree*)iqtree;
                for (auto it = stree->begin(); it != stree->end(); it++)
                    ((IQTree*)(*it))->addTreeToCandidateSet((*it)->getTreeString(),
                                                            (*it)->getCurScore(), false, MPIHelper::getInstance().getProcessID());
            }
        }
        if (params.min_iterations && !iqtree->isBifurcating()) {
            outError("Tree search does not work with initial multifurcating tree. Please specify `-n 0` to avoid this.");
        }
        
        // Compute maximum likelihood distance
        // ML distance is only needed for NNI/IQP
        
        if ((params.min_iterations <= 1 || params.numInitTrees <= 1) && params.start_tree != STT_BIONJ) {
            params.compute_ml_dist = false;
        }
        if ((params.user_file || params.start_tree == STT_RANDOM_TREE) && params.snni && !params.iqp) {
            params.compute_ml_dist = false;
        }
        if (params.constraint_tree_file) {
            params.compute_ml_dist = false;
        }
        if (iqtree->isSuperTreeUnlinked()) {
            params.compute_ml_dist = false;
        }
        //Todo: Check: is it always true that we've done this, if we reach this line?
        cout << "Wrote distance file to... " << iqtree->getDistanceFileWritten() << endl;
    }
    bool wantMLDistances = MPIHelper::getInstance().isMaster() && !iqtree->getCheckpoint()->getBool("finishedCandidateSet");
    if (wantMLDistances) {
        wantMLDistances = !finishedInitTree && ((!params.dist_file && params.compute_ml_dist) || params.leastSquareBranch);
    }
    //Compute ML distances, and generate BIONJ tree from those
    if (wantMLDistances || params.compute_ml_tree_only) {
        computeMLDist(params, *iqtree, getRealTime(), getCPUTime());
        bool wasMLDistanceWrittenToFile = false;
        if (!params.user_file) {
            if (params.start_tree != STT_RANDOM_TREE) {
                if (!params.compute_ml_tree_only) {
                    iqtree->resetCurScore();
                }
                double start_bionj = getRealTime();
                iqtree->computeBioNJ(params);
                if (verbose_mode >= VB_MED) {
                    cout << "Wall-clock time spent creating initial tree was "
                    << getRealTime() - start_bionj << " seconds" << endl;
                }
                wasMLDistanceWrittenToFile  = !params.dist_file;
                if (params.compute_ml_tree_only) {
                    iqtree->initializeAllPartialPars();
                    iqtree->clearAllPartialLH();
                    iqtree->fixNegativeBranch(iqtree->isSuperTree());
                    //Because wrapperFixNegativeBranch resets the score,
                    //and that complains if the number of threads isn't set.
                    //(but... if you set the number of threads first, it
                    //complains about the negative path lengths).
                    
                    //This fails if there are any lengths <=0 (so it has to
                    //go after the fix-up for negative branch lengths).
                    auto threadCount = iqtree->ensureNumberOfThreadsIsSet(&params);
                    cout << "Number of threads is " << threadCount << endl;
                    initTree = iqtree->ensureModelParametersAreSet(initEpsilon);
                } else {
                    iqtree->wrapperFixNegativeBranch(iqtree->isSuperTree());
                    iqtree->initializeAllPartialLh();
                    if (params.start_tree == STT_BIONJ) {
                        initTree = iqtree->optimizeModelParameters(params.min_iterations==0, initEpsilon);
                    } else {
                        initTree = iqtree->optimizeBranches();
                    }
                }
                cout << "Log-likelihood of " << params.start_tree_subtype_name
                    << " tree: " << iqtree->getCurScore() << endl;
                iqtree->candidateTrees.update(initTree, iqtree->getCurScore());
            }
        }
        if (!wasMLDistanceWrittenToFile && !params.dist_file) {
            double write_begin_time = getRealTime();
            iqtree->printDistanceFile();
            if (verbose_mode >= VB_MED) {
                #ifdef _OPENMP
                #pragma omp critical (io)
                #endif
                cout << "Time taken to write distance file ( " << iqtree->dist_file << ") : "
                << getRealTime() - write_begin_time << " seconds " << endl;
            }
        }
    }
    //iqtree->saveCheckpoint();
    double cputime_search_start = getCPUTime();
    double realtime_search_start = getRealTime();

    if (params.leastSquareNNI) {
        iqtree->computeSubtreeDists();
    }
    if (params.model_name == "WHTEST") {
        cout << endl << "Testing model homogeneity by Weiss & von Haeseler (2003)..." << endl;
        WHTest(params, *iqtree);
    }
    NodeVector pruned_taxa;
    StrVector linked_name;
    double *saved_dist_mat = iqtree->dist_matrix;
    double *pattern_lh = new double[iqtree->getAlnNPattern()];
    // prune stable taxa
    pruneTaxa(params, *iqtree, pattern_lh, pruned_taxa, linked_name);

    /***************************************** DO STOCHASTIC TREE SEARCH *******************************************/
    if (params.min_iterations > 0 && !params.tree_spr) {
        iqtree->doTreeSearch();
        iqtree->setAlignment(iqtree->aln);
    } else {
        iqtree->candidateTrees.saveCheckpoint();
        /* do SPR with likelihood function */
        if (params.tree_spr) {
            //tree.optimizeSPRBranches();
            cout << "Doing SPR Search" << endl;
            cout << "Start tree.optimizeSPR()" << endl;
            double spr_score = iqtree->optimizeSPR();
            cout << "Finish tree.optimizeSPR()" << endl;
            //double spr_score = tree.optimizeSPR(tree.curScore, (PhyloNode*) tree.root->neighbors[0]->node);
            if (spr_score <= iqtree->getCurScore()) {
                cout << "SPR search did not found any better tree" << endl;
            }
        }
    }
    // restore pruned taxa
    restoreTaxa(*iqtree, saved_dist_mat, pruned_taxa, linked_name);
    double search_cpu_time = getCPUTime() - cputime_search_start;
    double search_real_time = getRealTime() - realtime_search_start;

    // COMMENT THIS OUT BECAUSE IT DELETES ALL BRANCH LENGTHS OF SUBTREES!
//    if (iqtree.isSuperTree())
//            ((PhyloSuperTree*) iqtree)->mapTrees();

    if (!MPIHelper::getInstance().isMaster()) {
        delete[] pattern_lh;
        return;
    }

    if (params.snni && params.min_iterations && verbose_mode >= VB_MED) {
        cout << "Log-likelihoods of " << params.popSize << " best candidate trees: " << endl;
        iqtree->printBestScores();
        cout << endl;
    }

    if (!params.final_model_opt) {
        iqtree->setCurScore(iqtree->computeLikelihood());
    } else if (params.min_iterations) {
        iqtree->readTreeString(iqtree->getBestTrees()[0]);
        iqtree->initializeAllPartialLh();
        iqtree->clearAllPartialLH();
        cout << "--------------------------------------------------------------------" << endl;
        cout << "|                    FINALIZING TREE SEARCH                        |" << endl;
        cout << "--------------------------------------------------------------------" << endl;

        if (iqtree->getCheckpoint()->getBool("finishedModelFinal")) {
            iqtree->setCurScore(iqtree->computeLikelihood());
            cout << "CHECKPOINT: Final model parameters restored" << endl;
        } else {
            cout << "Performs final model parameters optimization" << endl;
            string tree;
            Params::getInstance().fixStableSplits = false;
            Params::getInstance().tabu = false;
            tree = iqtree->optimizeModelParameters(true);
            iqtree->addTreeToCandidateSet(tree, iqtree->getCurScore(), false, MPIHelper::getInstance().getProcessID());
            iqtree->getCheckpoint()->putBool("finishedModelFinal", true);
            iqtree->saveCheckpoint();
        }

    }
    if (iqtree->isSuperTree()) {
        ((PhyloSuperTree*) iqtree)->computeBranchLengths();
        ((PhyloSuperTree*) iqtree)->printBestPartitionParams((string(params.out_prefix) + ".best_model.nex").c_str());
    }

    cout << "BEST SCORE FOUND : " << iqtree->getCurScore() << endl;

    if (params.write_candidate_trees) {
        printTrees(iqtree->getBestTrees(), params, ".imd_trees");
    }

    if (params.pll)
        iqtree->inputModelPLL2IQTree();

    /* root the tree at the first sequence */
    // BQM: WHY SETTING THIS ROOT NODE????
//    iqtree->root = iqtree->findLeafName(iqtree->aln->getSeqName(0));
//    assert(iqtree->root);
    iqtree->setRootNode(params.root);


    if (!params.pll) {
        iqtree->computeLikelihood(pattern_lh);
        // compute logl variance
        iqtree->logl_variance = iqtree->computeLogLVariance();
    }
    printMiscInfo(params, *iqtree, pattern_lh);

    if (params.alisim_fundi_taxon_set.size() > 0 && !params.alisim_active) {
        cout << "Optimizing FunDi model..." << endl;
        double start_time = getRealTime();
        double score = iqtree->optimizeFundiModel();
        cout << "FunDi log-likelihood: " << score << endl;
        cout << "Time taken to optimize FunDi model: " << getRealTime() - start_time << " sec" << endl;
    }
    
    if (params.root_test) {
        cout << "Testing root positions..." << endl;
        string out_file = (string)params.out_prefix + ".roottest.trees";
        IntVector branch_ids;
        iqtree->testRootPosition(true, params.loglh_epsilon, branch_ids, out_file);
        vector<TreeInfo> info;
        IntVector distinct_ids;
        evaluateTrees(out_file, params, iqtree, info, distinct_ids);
        out_file = (string)params.out_prefix + ".roottest.csv";
        printTreeTestResults(info, distinct_ids, branch_ids, out_file);
    }
    
    /****** perform SH-aLRT test ******************/
    if ((params.aLRT_replicates > 0 || params.localbp_replicates > 0 || params.aLRT_test || params.aBayes_test) && !params.pll) {
        double mytime = getRealTime();
        params.aLRT_replicates = max(params.aLRT_replicates, params.localbp_replicates);
        cout << endl;
        if (params.aLRT_replicates > 0)
            cout << "Testing tree branches by SH-like aLRT with "
                << params.aLRT_replicates << " replicates..." << endl;
        if (params.localbp_replicates)
            cout << "Testing tree branches by local-BP test with " << params.localbp_replicates << " replicates..." << endl;
        if (params.aLRT_test)
            cout << "Testing tree branches by aLRT parametric test..." << endl;
        if (params.aBayes_test)
            cout << "Testing tree branches by aBayes parametric test..." << endl;
        iqtree->setRootNode(params.root);
        if (iqtree->isBifurcating()) {
            iqtree->testAllBranches(params.aLRT_threshold, iqtree->getCurScore(),
                    pattern_lh, params.aLRT_replicates, params.localbp_replicates, params.aLRT_test, params.aBayes_test);
            cout << getRealTime() - mytime << " sec." << endl;
        } else {
            outWarning("Tree is multifurcating and such test is not applicable");
            params.aLRT_replicates = params.localbp_replicates = params.aLRT_test = params.aBayes_test = 0;
        }
    }

    if (params.gbo_replicates > 0) {
        cout << "Creating " << RESAMPLE_NAME << " support values..." << endl;
        if (!params.online_bootstrap)
            outError("Obsolete feature");
//            runGuidedBootstrap(params, iqtree->aln, iqtree);
        else
            iqtree->summarizeBootstrap(params);
    }

    if (params.collapse_zero_branch) {
        cout << "Collapsing near-zero internal branches... ";
        cout << iqtree->collapseInternalBranches(NULL, NULL, params.min_branch_length*4);
        cout << " collapsed" << endl;
    }

    printFinalSearchInfo(params, *iqtree, search_cpu_time, search_real_time);

    if (params.gbo_replicates && params.online_bootstrap && params.print_ufboot_trees)
        iqtree->writeUFBootTrees(params);

    if (iqtree->rooted && params.gbo_replicates && params.online_bootstrap) {
        cout << "Computing rootstrap supports..." << endl;
        string saved = iqtree->getTreeString();
        MTreeSet trees;
        trees.init(iqtree->boot_trees, iqtree->rooted);
        iqtree->computeRootstrap(trees, true);
        iqtree->readTreeString(saved);
    }

    /*
    if (!iqtree->rooted && params.root && params.gbo_replicates && params.online_bootstrap) {
        cout << "Computing rootstrap supports using outgroup..." << endl;
        string saved = iqtree->getTreeString();
        iqtree->computeRootstrapUnrooted(iqtree->boot_trees, params.root);
        iqtree->readTreeString(saved);
    }
    */
    
    if (params.gbo_replicates && params.online_bootstrap && !iqtree->isSuperTreeUnlinked()) {
        
        cout << endl << "Computing " << RESAMPLE_NAME << " consensus tree..." << endl;
        string splitsfile = params.out_prefix;
        splitsfile += ".splits.nex";
        double weight_threshold = (params.split_threshold<1) ? params.split_threshold : (params.gbo_replicates-1.0)/params.gbo_replicates;
        weight_threshold *= 100.0;
        computeConsensusTree(splitsfile.c_str(), 0, 1e6, -1,
                             weight_threshold, NULL, params.out_prefix, NULL, &params);
        // now optimize branch lengths of the consensus tree
        string current_tree = iqtree->getTreeString();
        optimizeConTree(params, iqtree);
        // revert the best tree
        iqtree->readTreeString(current_tree);
    }
    if (Params::getInstance().writeDistImdTrees) {
        cout << endl;
        cout << "Recomputing the log-likelihood of the intermediate trees ... " << endl;
        iqtree->intermediateTrees.recomputeLoglOfAllTrees(*iqtree);
    }
    
    // BUG FIX: readTreeString(bestTreeString) not needed before this line
    iqtree->printResultTree();
    iqtree->saveCheckpoint();

    if (params.upper_bound_NNI) {
        string out_file_UB = params.out_prefix;
        out_file_UB += ".UB.NNI.main";
        ofstream out_UB;
        out_UB.exceptions(ios::failbit | ios::badbit);
        out_UB.open((char *) out_file_UB.c_str(), std::ofstream::out | std::ofstream::app);
        out_UB << iqtree->leafNum << "\t" << iqtree->aln->getNSite() << "\t" << iqtree->params->upper_bound_frac << "\t"
        << iqtree->skippedNNIub << "\t" << iqtree->totalNNIub << "\t" << iqtree->getBestScore() << endl;
        //iqtree->minUB << "\t" << iqtree->meanUB/iqtree->skippedNNIub << "\t" << iqtree->maxUB << endl;
        out_UB.close();
    }

    if (params.out_file)
        iqtree->printTree(params.out_file);

    delete[] pattern_lh;

    runApproximateBranchLengths(params, *iqtree);

}

/**********************************************************
 * MULTIPLE TREE RECONSTRUCTION
 ***********************************************************/
void runMultipleTreeReconstruction(Params &params, Alignment *alignment, IQTree *tree) {
    ModelCheckpoint *model_info = new ModelCheckpoint;
    
    if (params.suppress_output_flags & OUT_TREEFILE)
        outError("Suppress .treefile not allowed with -runs option");
    string treefile_name = params.out_prefix;
    treefile_name += ".treefile";
    string runtrees_name = params.out_prefix;
    runtrees_name += ".runtrees";
    DoubleVector runLnL;
    
    if (tree->getCheckpoint()->getVector("runLnL", runLnL)) {
        cout << endl << "CHECKPOINT: " << runLnL.size() << " independent run(s) restored" << endl;
    } else if (MPIHelper::getInstance().isMaster()) {
        // first empty the runtrees file
        try {
            ofstream tree_out;
            tree_out.exceptions(ios::failbit | ios::badbit);
            tree_out.open(runtrees_name.c_str());
            tree_out.close();
        } catch (ios::failure) {
            outError(ERR_WRITE_OUTPUT, runtrees_name);
        }
    }
    
    double start_time = getCPUTime();
    double start_real_time = getRealTime();
    
    int orig_seed = params.ran_seed;
    int run;
    int best_run = 0;
    for (run = 0; run < runLnL.size(); run++)
        if (runLnL[run] > runLnL[best_run])
            best_run = run;

    // do multiple tree reconstruction
    for (run = runLnL.size(); run < params.num_runs; run++) {

        tree->getCheckpoint()->startStruct("run" + convertIntToString(run+1));
        
        params.ran_seed = orig_seed + run*1000 + MPIHelper::getInstance().getProcessID();
        
        cout << endl << "---> START RUN NUMBER " << run + 1 << " (seed: " << params.ran_seed << ")" << endl;
        
        tree->getCheckpoint()->put("seed", params.ran_seed);
        
        // initialize random stream for replicating the run
        
        int *saved_randstream = randstream;
        init_random(params.ran_seed);
        
        IQTree *iqtree;
        if (alignment->isSuperAlignment()){
            if(params.partition_type != BRLEN_OPTIMIZE){
                iqtree = new PhyloSuperTreePlen((SuperAlignment*) alignment, (PhyloSuperTree*) tree);
            } else {
                iqtree = new PhyloSuperTree((SuperAlignment*) alignment, (PhyloSuperTree*) tree);
            }
        } else {
            // allocate heterotachy tree if neccessary
            int pos = posRateHeterotachy(alignment->model_name);
            
            if (params.num_mixlen > 1) {
                iqtree = new PhyloTreeMixlen(alignment, params.num_mixlen);
            } else if (pos != string::npos) {
                iqtree = new PhyloTreeMixlen(alignment, 0);
            } else
                iqtree = new IQTree(alignment);
        }
        
        if (!tree->constraintTree.empty()) {
            iqtree->constraintTree.readConstraint(tree->constraintTree);
        }
        
        // set checkpoint
        iqtree->setCheckpoint(tree->getCheckpoint());
        iqtree->num_precision = tree->num_precision;
        
        runTreeReconstruction(params, iqtree);
        // read in the output tree file
        stringstream ss;
        iqtree->printTree(ss);
        if (MPIHelper::getInstance().isMaster())
            try {
                ofstream tree_out;
                tree_out.exceptions(ios::failbit | ios::badbit);
                tree_out.open(runtrees_name.c_str(), ios_base::out | ios_base::app);
                tree_out.precision(10);
                tree_out << "[ lh=" << iqtree->getBestScore() << " ]";
                tree_out << ss.str() << endl;
                tree_out.close();
            } catch (ios::failure) {
                outError(ERR_WRITE_OUTPUT, runtrees_name);
            }
        // fix bug: set the model for original tree after testing
        if ((params.model_name.substr(0,4) == "TEST" || params.model_name.substr(0,2) == "MF") && tree->isSuperTree()) {
            PhyloSuperTree *stree = ((PhyloSuperTree*)tree);
            stree->part_info =  ((PhyloSuperTree*)iqtree)->part_info;
        }
        runLnL.push_back(iqtree->getBestScore());

        if (MPIHelper::getInstance().isMaster()) {
            if (params.num_bootstrap_samples > 0 && params.consensus_type == CT_CONSENSUS_TREE &&
                (run == 0 || iqtree->getBestScore() > runLnL[best_run])) {
                // 2017-12-08: optimize branch lengths of consensus tree
                // now optimize branch lengths of the consensus tree
                string current_tree = iqtree->getTreeString();
                optimizeConTree(params, iqtree);
                // revert the best tree
                iqtree->readTreeString(current_tree);
                iqtree->saveCheckpoint();
            }
        }
        if (iqtree->getBestScore() > runLnL[best_run])
            best_run = run;
            
        if (params.num_runs == 1)
            reportPhyloAnalysis(params, *iqtree, *model_info);
        delete iqtree;
        
        tree->getCheckpoint()->endStruct();
        // clear all checkpointed information
//        tree->getCheckpoint()->keepKeyPrefix("iqtree");
        tree->getCheckpoint()->putVector("runLnL", runLnL);
//        tree->getCheckpoint()->putBool("finished", false);
        tree->getCheckpoint()->dump(true);
        // restore randstream
        finish_random();
        randstream = saved_randstream;
    }
    
    cout << endl << "---> SUMMARIZE RESULTS FROM " << runLnL.size() << " RUNS" << endl << endl;
    
    cout << "Run " << best_run+1 <<  " gave best log-likelihood: " << runLnL[best_run] << endl;

    // initialize tree and model strucgture
    ModelsBlock *models_block = readModelsDefinition(params);
    tree->setParams(&params);
    tree->setNumThreads(params.num_threads);
    if (!tree->getModelFactory()) {
        tree->initializeModel(params, tree->aln->model_name, models_block);
    }
    if (tree->getRate()->isHeterotachy() && !tree->isMixlen()) {
        ASSERT(0 && "Heterotachy tree not properly created");
    }
    delete models_block;

    // restore the tree and model from the best run
    tree->getCheckpoint()->startStruct("run" + convertIntToString(best_run+1));
    tree->restoreCheckpoint();
    tree->getModelFactory()->restoreCheckpoint();
    tree->setCurScore(runLnL[best_run]);
    if (params.gbo_replicates && !tree->isSuperTreeUnlinked()) {
        
        string out_file = (string)params.out_prefix + ".splits";
        if (params.print_splits_file) {
            tree->boot_splits.back()->saveFile(out_file.c_str(), IN_OTHER, true);
            cout << "Split supports printed to star-dot file " << out_file << endl;
        }

        if (params.print_splits_nex_file) {
            out_file = (string)params.out_prefix + ".splits.nex";
            tree->boot_splits.back()->saveFile(out_file.c_str(), IN_NEXUS, false);
            cout << "Split supports printed to NEXUS file " << out_file << endl;
        }

        // overwrite .ufboot trees
        if (params.print_ufboot_trees)
            tree->writeUFBootTrees(params);

        // overwrite .contree
        string contree;
        if (!tree->getCheckpoint()->getString("contree", contree))
            ASSERT(0 && "Couldn't restore contree");
        string contree_file = string(params.out_prefix) + ".contree";
        string current_tree = tree->getTreeString();
        tree->readTreeString(contree);
        tree->setRootNode(params.root);
        tree->insertTaxa(tree->removed_seqs, tree->twin_seqs);
        tree->printTree(contree_file.c_str(), WT_BR_LEN | WT_BR_LEN_FIXED_WIDTH | WT_SORT_TAXA | WT_NEWLINE);
        tree->readTreeString(current_tree);
        cout << "Consensus tree written to " << contree_file << endl;
    }
    tree->getCheckpoint()->endStruct();
    
    // overwrite .treefile
    tree->printResultTree();

    if (MPIHelper::getInstance().isMaster()) {
        cout << "Total CPU time for " << params.num_runs << " runs: " << (getCPUTime() - start_time) << " seconds." << endl;
        cout << "Total wall-clock time for " << params.num_runs << " runs: " << (getRealTime() - start_real_time) << " seconds." << endl << endl;
    }
    delete model_info;
}

void computeLoglFromUserInputGAMMAInvar(Params &params, IQTree &iqtree) {
    RateHeterogeneity *site_rates = iqtree.getRate();
    site_rates->setFixPInvar(true);
    site_rates->setFixGammaShape(true);
    vector<double> alphas, p_invars, logl;
    ifstream aiFile;
    aiFile.open(params.alpha_invar_file, ios_base::in);
    if (aiFile.good()) {
        double alpha, p_invar;
        while (aiFile >> alpha >> p_invar) {
            alphas.push_back(alpha);
            p_invars.push_back(p_invar);
        }
        aiFile.close();
        cout << "Computing tree logl based on the alpha and p_invar values in " << params.alpha_invar_file << " ..." <<
        endl;
    } else {
        stringstream errMsg;
        errMsg << "Could not find file: " << params.alpha_invar_file;
        outError(errMsg.str().c_str());
    }
    string aiResultsFileName = string(params.out_prefix) + "_" + string(params.alpha_invar_file) + ".results";
    ofstream aiFileResults;
    aiFileResults.open(aiResultsFileName.c_str());
    aiFileResults << fixed;
    aiFileResults.precision(4);
    DoubleVector lenvec;
    aiFileResults << "Alpha P_Invar Logl TreeLength\n";
    for (int i = 0; i < alphas.size(); i++) {
        iqtree.saveBranchLengths(lenvec);
        aiFileResults << alphas.at(i) << " " << p_invars.at(i) << " ";
        site_rates->setGammaShape(alphas.at(i));
        site_rates->setPInvar(p_invars.at(i));
        iqtree.clearAllPartialLH();
        double lh = iqtree.getModelFactory()->optimizeParameters(params.fixed_branch_length, false, 0.001);
        aiFileResults << lh << " " << iqtree.treeLength() << "\n";
        iqtree.restoreBranchLengths(lenvec);
    }
    aiFileResults.close();
    cout << "Results were written to: " << aiResultsFileName << endl;
    cout << "Wall clock time used: " << getRealTime() - params.start_real_time << endl;
}

void searchGAMMAInvarByRestarting(IQTree &iqtree) {
    if (!Params::getInstance().fixed_branch_length)
        iqtree.setCurScore(iqtree.optimizeAllBranches(1));
    else
        iqtree.setCurScore(iqtree.computeLikelihood());
    RateHeterogeneity* site_rates = (iqtree.getRate());
    double values[] = { 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0 };
    vector<double> initAlphas;
    if (Params::getInstance().randomAlpha) {
        while (initAlphas.size() < 10) {
            double initAlpha = random_double();
            initAlphas.push_back(initAlpha + iqtree.params->min_gamma_shape*2);
        }
    } else {
        initAlphas.assign(values, values+10);
    }
    double bestLogl = iqtree.getCurScore();
    double bestAlpha = 0.0;
    double bestPInvar = 0.0;
    double initPInvar = iqtree.getRate()->getPInvar();

    /* Back up branch lengths and substitutional rates */
    DoubleVector lenvec;
    DoubleVector bestLens;
    iqtree.saveBranchLengths(lenvec);
    int numRateEntries = iqtree.getModel()->getNumRateEntries();
    double *rates = new double[numRateEntries];
    double *bestRates = new double[numRateEntries];
    iqtree.getModel()->getRateMatrix(rates);
    int numStates = iqtree.aln->num_states;
    double *state_freqs = new double[numStates];
    iqtree.getModel()->getStateFrequency(state_freqs);
    double *bestStateFreqs =  new double[numStates];

    for (int i = 0; i < 10; i++) {
        cout << endl;
        cout << "Testing alpha: " << initAlphas[i] << endl;
        // Initialize model parameters
        iqtree.restoreBranchLengths(lenvec);
        ((ModelMarkov*) iqtree.getModel())->setRateMatrix(rates);
        ((ModelMarkov*) iqtree.getModel())->setStateFrequency(state_freqs);
        iqtree.getModel()->decomposeRateMatrix();
        site_rates->setGammaShape(initAlphas[i]);
        site_rates->setPInvar(initPInvar);
        iqtree.clearAllPartialLH();
        iqtree.optimizeModelParameters(verbose_mode >= VB_MED, Params::getInstance().testAlphaEps);
        double estAlpha = iqtree.getRate()->getGammaShape();
        double estPInv = iqtree.getRate()->getPInvar();
        double logl = iqtree.getCurScore();
        cout << "Est. alpha: " << estAlpha << " / Est. pinv: " << estPInv
        << " / Logl: " << logl << endl;

        if (iqtree.getCurScore() > bestLogl) {
            bestLogl = logl;
            bestAlpha = estAlpha;
            bestPInvar = estPInv;
            bestLens.clear();
            iqtree.saveBranchLengths(bestLens);
            iqtree.getModel()->getRateMatrix(bestRates);
            iqtree.getModel()->getStateFrequency(bestStateFreqs);
        }
    }
    site_rates->setGammaShape(bestAlpha);
    site_rates->setFixGammaShape(false);
    site_rates->setPInvar(bestPInvar);
    site_rates->setFixPInvar(false);
    ((ModelMarkov*) iqtree.getModel())->setRateMatrix(bestRates);
    ((ModelMarkov*) iqtree.getModel())->setStateFrequency(bestStateFreqs);
    iqtree.restoreBranchLengths(bestLens);
    iqtree.getModel()->decomposeRateMatrix();
    iqtree.clearAllPartialLH();
    iqtree.setCurScore(iqtree.computeLikelihood());
    cout << endl;
    cout << "Best initial alpha: " << bestAlpha << " / initial pinv: " << bestPInvar << " / ";
    cout << "Logl: " << iqtree.getCurScore() << endl;

    delete [] rates;
    delete [] state_freqs;
    delete [] bestRates;
    delete [] bestStateFreqs;
}

// Test alpha fom 0.1 to 15 and p_invar from 0.1 to 0.99, stepsize = 0.01
void exhaustiveSearchGAMMAInvar(Params &params, IQTree &iqtree) {
    double alphaMin = 0.01;
    double alphaMax = 10.00;
    double p_invarMin = 0.01;
    double p_invarMax = 1.00;
//    double p_invarMax = iqtree.aln->frac_const_sites;
    double stepSize = 0.01;
    int numAlpha = (int) floor((alphaMax - alphaMin)/stepSize);
    int numInvar = (int) floor((p_invarMax - p_invarMin)/stepSize);

    cout << "EVALUATING " << numAlpha*numInvar << " COMBINATIONS OF " << " alpha=" << alphaMin << ".." << alphaMax
         << " AND " << " p-invar=" << p_invarMin << ".." << p_invarMax
         << " (epsilon: " << params.modelEps << ")" << endl;

//    vector<string> results;
//    results.reserve((unsigned long) (numAlpha * numInvar));
    DoubleVector lenvec;
    iqtree.saveBranchLengths(lenvec);

    RateHeterogeneity* site_rates = (iqtree.getRate());
    site_rates->setFixPInvar(true);
    site_rates->setFixGammaShape(true);

    string aiResultsFileName = string(params.out_prefix) + ".ai_results";
    ofstream aiFileResults;
    aiFileResults.open(aiResultsFileName.c_str());
    aiFileResults << fixed;
    aiFileResults.precision(4);
    aiFileResults << "alpha p_invar logl tree_len\n";

    for (double alpha = alphaMin; alpha < alphaMax; alpha = alpha + stepSize) {
        cout << "alpha = " << alpha << endl;
        for (double p_invar = p_invarMin; p_invar < p_invarMax; p_invar = p_invar + stepSize) {
            site_rates->setGammaShape(alpha);
            site_rates->setPInvar(p_invar);
            iqtree.clearAllPartialLH();
            double lh = iqtree.getModelFactory()->optimizeParameters(params.fixed_branch_length, false, params.modelEps);
//            stringstream ss;
//            ss << fixed << setprecision(2) << alpha << " " << p_invar << " " << lh << " " << iqtree.treeLength();
            aiFileResults << alpha << " " << p_invar << " " << lh << " " << iqtree.treeLength() << endl;
            //cout << ss.str() << endl;
//            results.push_back(ss.str());
            iqtree.restoreBranchLengths(lenvec);
        }
    }
//    for (vector<string>::iterator it = results.begin(); it != results.end(); it++) {
//                aiFileResults << (*it) << endl;
//            }
    aiFileResults.close();
    cout << "Results were written to: " << aiResultsFileName << endl;
    cout << "Wall clock time used: " << getRealTime() - params.start_real_time << endl;
}

/**********************************************************
 * STANDARD NON-PARAMETRIC BOOTSTRAP
 ***********************************************************/
void runStandardBootstrap(Params &params, Alignment *alignment, IQTree *tree) {
    ModelCheckpoint *model_info = new ModelCheckpoint;
    StrVector removed_seqs, twin_seqs;

    // turn off all branch tests
    int saved_aLRT_replicates = params.aLRT_replicates;
    int saved_localbp_replicates = params.localbp_replicates;
    bool saved_aLRT_test = params.aLRT_test;
    bool saved_aBayes_test = params.aBayes_test;
    params.aLRT_replicates = 0;
    params.localbp_replicates = 0;
    params.aLRT_test = false;
    params.aBayes_test = false;
    
    if (params.suppress_output_flags & OUT_TREEFILE)
        outError("Suppress .treefile not allowed for standard bootstrap");
    string treefile_name = params.out_prefix;
    treefile_name += ".treefile";
    string boottrees_name = params.out_prefix;
    boottrees_name += ".boottrees";
    string bootaln_name = params.out_prefix;
    bootaln_name += ".bootaln";
    string bootlh_name = params.out_prefix;
    bootlh_name += ".bootlh";
    int bootSample = 0;
    if (tree->getCheckpoint()->get("bootSample", bootSample)) {
        cout << "CHECKPOINT: " << bootSample << " bootstrap analyses restored" << endl;
    } else if (MPIHelper::getInstance().isMaster()) {
        // first empty the boottrees file
        try {
            ofstream tree_out;
            tree_out.exceptions(ios::failbit | ios::badbit);
            tree_out.open(boottrees_name.c_str());
            tree_out.close();
        } catch (ios::failure) {
            outError(ERR_WRITE_OUTPUT, boottrees_name);
        }

        // empty the bootaln file
        if (params.print_bootaln)
        try {
            ofstream tree_out;
            tree_out.exceptions(ios::failbit | ios::badbit);
            tree_out.open(bootaln_name.c_str());
            tree_out.close();
        } catch (ios::failure) {
            outError(ERR_WRITE_OUTPUT, bootaln_name);
        }
    }

    double start_time = getCPUTime();
    double start_real_time = getRealTime();

    startTreeReconstruction(params, tree, *model_info);
    
    // 2018-06-21: bug fix: alignment might be changed by -m ...MERGE
    alignment = tree->aln;
    
    // do bootstrap analysis
    for (int sample = bootSample; sample < params.num_bootstrap_samples; sample++) {
        cout << endl << "===> START " << RESAMPLE_NAME_UPPER << " REPLICATE NUMBER "
                << sample + 1 << endl << endl;

        // 2015-12-17: initialize random stream for creating bootstrap samples
        // mainly so that checkpointing does not need to save bootstrap samples
        int *saved_randstream = randstream;
        init_random(params.ran_seed + sample);

        Alignment* bootstrap_alignment;
        cout << "Creating " << RESAMPLE_NAME << " alignment (seed: " << params.ran_seed+sample << ")..." << endl;

        if (alignment->isSuperAlignment())
            bootstrap_alignment = new SuperAlignment;
        else
            bootstrap_alignment = new Alignment;
        bootstrap_alignment->createBootstrapAlignment(alignment, NULL, params.bootstrap_spec);

        // restore randstream
        finish_random();
        randstream = saved_randstream;

        if (params.print_tree_lh && MPIHelper::getInstance().isMaster()) {
            double prob;
            bootstrap_alignment->multinomialProb(*alignment, prob);
            ofstream boot_lh;
            if (sample == 0)
                boot_lh.open(bootlh_name.c_str());
            else
                boot_lh.open(bootlh_name.c_str(), ios_base::out | ios_base::app);
            boot_lh << "0\t" << prob << endl;
            boot_lh.close();
        }
        IQTree *boot_tree;
        if (alignment->isSuperAlignment()){
            if(params.partition_type != BRLEN_OPTIMIZE){
                boot_tree = new PhyloSuperTreePlen((SuperAlignment*) bootstrap_alignment, (PhyloSuperTree*) tree);
            } else {
                boot_tree = new PhyloSuperTree((SuperAlignment*) bootstrap_alignment, (PhyloSuperTree*) tree);
            }
        } else {
            // allocate heterotachy tree if neccessary
            int pos = posRateHeterotachy(alignment->model_name);
            
            if (params.num_mixlen > 1) {
                boot_tree = new PhyloTreeMixlen(bootstrap_alignment, params.num_mixlen);
            } else if (pos != string::npos) {
                boot_tree = new PhyloTreeMixlen(bootstrap_alignment, 0);
            } else
                boot_tree = new IQTree(bootstrap_alignment);
        }
        if (params.print_bootaln && MPIHelper::getInstance().isMaster()) {
            bootstrap_alignment->printAlignment(params.aln_output_format, bootaln_name.c_str(), true);
        }

        if (params.print_boot_site_freq && MPIHelper::getInstance().isMaster()) {
            printSiteStateFreq((((string)params.out_prefix)+"."+convertIntToString(sample)+".bootsitefreq").c_str(), bootstrap_alignment);
                bootstrap_alignment->printAlignment(params.aln_output_format, (((string)params.out_prefix)+"."+convertIntToString(sample)+".bootaln").c_str());
        }

        if (!tree->constraintTree.empty()) {
            boot_tree->constraintTree.readConstraint(tree->constraintTree);
        }

        // set checkpoint
        boot_tree->setCheckpoint(tree->getCheckpoint());
        boot_tree->num_precision = tree->num_precision;

        runTreeReconstruction(params, boot_tree);
        // read in the output tree file
        stringstream ss;
        boot_tree->printTree(ss);
//        try {
//            ifstream tree_in;
//            tree_in.exceptions(ios::failbit | ios::badbit);
//            tree_in.open(treefile_name.c_str());
//            tree_in >> tree_str;
//            tree_in.close();
//        } catch (ios::failure) {
//            outError(ERR_READ_INPUT, treefile_name);
//        }
        // write the tree into .boottrees file
        if (MPIHelper::getInstance().isMaster())
        try {
            ofstream tree_out;
            tree_out.exceptions(ios::failbit | ios::badbit);
            tree_out.open(boottrees_name.c_str(), ios_base::out | ios_base::app);
            tree_out << ss.str() << endl;
            tree_out.close();
        } catch (ios::failure) {
            outError(ERR_WRITE_OUTPUT, boottrees_name);
        }
        // OBSOLETE fix bug: set the model for original tree after testing
//        if ((params.model_name.substr(0,4) == "TEST" || params.model_name.substr(0,2) == "MF") && tree->isSuperTree()) {
//            PhyloSuperTree *stree = ((PhyloSuperTree*)tree);
//            stree->part_info =  ((PhyloSuperTree*)boot_tree)->part_info;
//        }
        if (params.num_bootstrap_samples == 1)
            reportPhyloAnalysis(params, *boot_tree, *model_info);
        // WHY was the following line missing, which caused memory leak?
        bootstrap_alignment = boot_tree->aln;
        delete boot_tree;
        // fix bug: bootstrap_alignment might be changed
        delete bootstrap_alignment;

        // clear all checkpointed information
        tree->getCheckpoint()->keepKeyPrefix("iqtree");
        tree->getCheckpoint()->put("bootSample", sample+1);
        tree->getCheckpoint()->putBool("finished", false);
        tree->getCheckpoint()->dump(true);
    }


    if (params.consensus_type == CT_CONSENSUS_TREE && MPIHelper::getInstance().isMaster()) {

        cout << endl << "===> COMPUTE CONSENSUS TREE FROM " << params.num_bootstrap_samples
            << " " << RESAMPLE_NAME_UPPER << " TREES" << endl << endl;
        string root_name = (params.root) ? params.root : alignment->getSeqName(0);
        const char* saved_root = params.root;
        params.root = root_name.c_str();
        computeConsensusTree(boottrees_name.c_str(), 0, 1e6, -1,
                params.split_threshold, NULL, params.out_prefix, NULL, &params);
        params.root = saved_root;
    }

    if (params.compute_ml_tree) {
        cout << endl << "===> START ANALYSIS ON THE ORIGINAL ALIGNMENT" << endl << endl;
        // restore branch tests
        params.aLRT_replicates = saved_aLRT_replicates;
        params.localbp_replicates = saved_localbp_replicates;
        params.aLRT_test = saved_aLRT_test;
        params.aBayes_test = saved_aBayes_test;

        if (params.num_runs == 1)
            runTreeReconstruction(params, tree);
        else
            runMultipleTreeReconstruction(params, tree->aln, tree);

        if (MPIHelper::getInstance().isMaster()) {
            if (params.consensus_type == CT_CONSENSUS_TREE && params.num_runs == 1) {
                // 2017-12-08: optimize branch lengths of consensus tree
                optimizeConTree(params, tree);
            }

            cout << endl << "===> ASSIGN " << RESAMPLE_NAME_UPPER
                << " SUPPORTS TO THE TREE FROM ORIGINAL ALIGNMENT" << endl << endl;
            MExtTree ext_tree;
            assignBootstrapSupport(boottrees_name.c_str(), 0, 1e6,
                    treefile_name.c_str(), false, treefile_name.c_str(),
                    params.out_prefix, ext_tree, NULL, &params);
            tree->copyTree(&ext_tree);
            if (tree->rooted) {
                cout << "Computing rootstrap supports from " << params.num_bootstrap_samples << " bootstrap trees..." << endl;
                string saved = tree->getTreeString();
                MTreeSet trees(boottrees_name.c_str(), tree->rooted, 0, params.num_bootstrap_samples);
                tree->computeRootstrap(trees, false);
                tree->readTreeString(saved);
            }
            reportPhyloAnalysis(params, *tree, *model_info);

        }
    } else if (params.consensus_type == CT_CONSENSUS_TREE && MPIHelper::getInstance().isMaster()) {
        int mi = params.min_iterations;
        STOP_CONDITION sc = params.stop_condition;
        params.min_iterations = 0;
        params.stop_condition = SC_FIXED_ITERATION;
        runTreeReconstruction(params, tree);
        params.min_iterations = mi;
        params.stop_condition = sc;
        tree->stop_rule.initialize(params);
        optimizeConTree(params, tree);
        reportPhyloAnalysis(params, *tree, *model_info);
    } else
        cout << endl;

#ifdef USE_BOOSTER
    if (params.transfer_bootstrap) {
        // transfer bootstrap expectation (TBE)
        cout << "Performing transfer bootstrap expectation..." << endl;
        string input_tree = (string)params.out_prefix + ".treefile";
        string boot_trees = (string)params.out_prefix + ".boottrees";
        string out_tree = (string)params.out_prefix + ".tbe.tree";
        string out_raw_tree = (string)params.out_prefix + ".tbe.rawtree";
        string stat_out = (string)params.out_prefix + ".tbe.stat";
        main_booster(input_tree.c_str(), boot_trees.c_str(), out_tree.c_str(),
                     (params.transfer_bootstrap==2) ? out_raw_tree.c_str() : NULL,
                     stat_out.c_str(), (verbose_mode >= VB_MED) ? 0 : 1);
        cout << "TBE tree written to " << out_tree << endl;
        if (params.transfer_bootstrap == 2)
            cout << "TBE raw tree written to " << out_raw_tree << endl;
        cout << "TBE statistic written to " << stat_out << endl;
        cout << endl;
    }
#endif
    
    if (MPIHelper::getInstance().isMaster()) {
        cout << "Total CPU time for " << RESAMPLE_NAME << ": " << (getCPUTime() - start_time) << " seconds." << endl;
    cout << "Total wall-clock time for " << RESAMPLE_NAME << ": " << (getRealTime() - start_real_time) << " seconds." << endl << endl;
    cout << "Non-parametric " << RESAMPLE_NAME << " results written to:" << endl;
    if (params.print_bootaln)
        cout << RESAMPLE_NAME_I << " alignments:     " << params.out_prefix << ".bootaln" << endl;
    cout << "  " << RESAMPLE_NAME_I << " trees:          " << params.out_prefix << ".boottrees" << endl;
    if (params.consensus_type == CT_CONSENSUS_TREE)
        cout << "  Consensus tree:           " << params.out_prefix << ".contree" << endl;
    cout << endl;
    }
    delete model_info;
}

void convertAlignment(Params &params, IQTree *iqtree) {
    Alignment *alignment = iqtree->aln;
    if (params.num_bootstrap_samples || params.print_bootaln) {
        // create bootstrap alignment
        Alignment* bootstrap_alignment;
        cout << "Creating " << RESAMPLE_NAME << " alignment..." << endl;
        if (alignment->isSuperAlignment())
            bootstrap_alignment = new SuperAlignment;
        else
            bootstrap_alignment = new Alignment;
        bootstrap_alignment->createBootstrapAlignment(alignment, NULL, params.bootstrap_spec);
        delete alignment;
        alignment = bootstrap_alignment;
        iqtree->aln = alignment;
    }

    int exclude_sites = 0;
    if (params.aln_nogaps)
        exclude_sites += EXCLUDE_GAP;
    if (params.aln_no_const_sites)
        exclude_sites += EXCLUDE_INVAR;

    if (alignment->isSuperAlignment()) {
        alignment->printAlignment(params.aln_output_format, params.aln_output, false, params.aln_site_list,
                                  exclude_sites, params.ref_seq_name);
        if (params.print_subaln)
            ((SuperAlignment*)alignment)->printSubAlignments(params);
        if (params.aln_output_format != IN_NEXUS) {
            string partition_info = string(params.aln_output) + ".nex";
            ((SuperAlignment*)alignment)->printPartition(partition_info.c_str(), params.aln_output);
            partition_info = (string)params.aln_output + ".partitions";
            ((SuperAlignment*)alignment)->printPartitionRaxml(partition_info.c_str());
        }
    } else if (params.gap_masked_aln) {
        Alignment out_aln;
        Alignment masked_aln(params.gap_masked_aln, params.sequence_type, params.intype, params.model_name);
        out_aln.createGapMaskedAlignment(&masked_aln, alignment);
        out_aln.printAlignment(params.aln_output_format, params.aln_output, false, params.aln_site_list,
                exclude_sites, params.ref_seq_name);
        string str = params.gap_masked_aln;
        str += ".sitegaps";
        out_aln.printSiteGaps(str.c_str());
    } else  {
        alignment->printAlignment(params.aln_output_format, params.aln_output, false, params.aln_site_list,
                exclude_sites, params.ref_seq_name);
    }
}

/**
    2016-08-04: compute a site frequency model for profile mixture model
*/
void computeSiteFrequencyModel(Params &params, Alignment *alignment) {

    cout << endl << "===> COMPUTING SITE FREQUENCY MODEL BASED ON TREE FILE " << params.tree_freq_file << endl;
    ASSERT(params.tree_freq_file);
    PhyloTree *tree = new PhyloTree(alignment);
    tree->setParams(&params);
    bool myrooted = params.is_rooted;
    tree->readTree(params.tree_freq_file, myrooted);
    tree->setAlignment(alignment);
    tree->setRootNode(params.root);
    
    ModelsBlock *models_block = readModelsDefinition(params);
    tree->setModelFactory(new ModelFactory(params, alignment->model_name, tree, models_block));
    delete models_block;
    tree->setModel(tree->getModelFactory()->model);
    tree->setRate(tree->getModelFactory()->site_rate);
    tree->setLikelihoodKernel(params.SSE);
    tree->setNumThreads(params.num_threads);
    
    if (!tree->getModel()->isMixture())
        outError("No mixture model was specified!");
    uint64_t mem_size = tree->getMemoryRequired();
    uint64_t total_mem = getMemorySize();
    cout << "NOTE: " << (mem_size / 1024) / 1024 << " MB RAM is required!" << endl;
    if (mem_size >= total_mem) {
        outError("Memory required exceeds your computer RAM size!");
    }
#ifdef BINARY32
    if (mem_size >= 2000000000) {
        outError("Memory required exceeds 2GB limit of 32-bit executable");
    }
#endif

    tree->ensureNumberOfThreadsIsSet(nullptr);

    tree->initializeAllPartialLh();
    // 2017-12-07: Increase espilon ten times (0.01 -> 0.1) to speedup PMSF computation
    tree->getModelFactory()->optimizeParameters(params.fixed_branch_length, true, params.modelEps*10);

    size_t nptn = alignment->getNPattern(), nstates = alignment->num_states;
    double *ptn_state_freq = new double[nptn*nstates];
    tree->computePatternStateFreq(ptn_state_freq);
    alignment->site_state_freq.resize(nptn);
    for (size_t ptn = 0; ptn < nptn; ptn++) {
        double *f = new double[nstates];
        memcpy(f, ptn_state_freq+ptn*nstates, sizeof(double)*nstates);
        alignment->site_state_freq[ptn] = f;
    }
    alignment->getSitePatternIndex(alignment->site_model);
    printSiteStateFreq(((string)params.out_prefix+".sitefreq").c_str(), tree, ptn_state_freq);
    params.print_site_state_freq = WSF_NONE;
    
    delete [] ptn_state_freq;
    delete tree;
    
    cout << endl << "===> CONTINUE ANALYSIS USING THE INFERRED SITE FREQUENCY MODEL" << endl;
}


/**********************************************************
 * TOP-LEVEL FUNCTION
 ***********************************************************/

IQTree *newIQTree(Params &params, Alignment *alignment) {
    IQTree *tree;
    
    if (alignment->isSuperAlignment()) {
        if (params.partition_type == TOPO_UNLINKED) {
            tree = new PhyloSuperTreeUnlinked((SuperAlignment*)alignment);
        } else if(params.partition_type != BRLEN_OPTIMIZE){
            // initialize supertree - Proportional Edges case
            tree = new PhyloSuperTreePlen((SuperAlignment*)alignment, params.partition_type);
        } else {
            // initialize supertree stuff if user specifies partition file with -sp option
            tree = new PhyloSuperTree((SuperAlignment*)alignment);
        }
        // this alignment will actually be of type SuperAlignment
        //        alignment = tree->aln;
        if (((PhyloSuperTree*)tree)->rescale_codon_brlen)
            cout << "NOTE: Mixed codon and other data, branch lengths of codon partitions are rescaled by 3!" << endl;
        
    } else {
        // allocate heterotachy tree if neccessary
        int pos = posRateHeterotachy(alignment->model_name);
        
        if (params.num_mixlen > 1) {
            tree = new PhyloTreeMixlen(alignment, params.num_mixlen);
        } else if (pos != string::npos) {
            tree = new PhyloTreeMixlen(alignment, 0);
        } else
            tree = new IQTree(alignment);
    }

    return tree;
}

// return how many char c inside the infile
int checkCharInFile(char* infile, char c) {
    ifstream fin;
    string aline;
    size_t i,k;
    k=0;
    fin.open(infile);
    while (getline(fin,aline)) {
        for (i=0; i<aline.length(); i++) {
            if (aline[i] == c)
                k++;
        }
    }
    fin.close();
    return k;
}

IQTree *newIQTreeMix(Params &params, Alignment *alignment, int numTree = 0) {
    int i, k;
    vector<IQTree*> trees;
    
    if (numTree == 1) {
        outError("The number after +T has to be greater than 1");
    }
    
    // check how many trees inside the user input file
    k = checkCharInFile(params.user_file, ';');
    if (k <= 1) {
        outError("Tree mixture model only supports at least 2 trees inside the tree file: " + string(params.user_file) + ". Each tree must be followed by the character ';'.");
    }
    
    if (numTree == 0) {
        numTree = k;
        cout << "Number of input trees: " << numTree << endl;
    } else if (numTree < k) {
        cout << "Note: Only " << numTree << " trees are considered, although there are more than " << numTree << " trees in the tree file: " << params.user_file << endl;
    } else if (numTree > k) {
        outError("The number of trees inside the tree file '" + string(params.user_file) + "' is less than " + convertIntToString(numTree));
    }
    
    for (i=0; i<numTree; i++) {
        trees.push_back(newIQTree(params,alignment));
    }
    // if (params.optimize_params_use_hmm)
        return new IQTreeMixHmm(params, alignment, trees);
    // else
    //    return new IQTreeMix(params, alignment, trees);
}

/** get ID of bad or good symtest results */
void getSymTestID(vector<SymTestResult> &res, set<int> &id, bool bad_res) {
    if (bad_res) {
        // get significant test ID
        switch (Params::getInstance().symtest) {
            case SYMTEST_BINOM:
                for (auto i = res.begin(); i != res.end(); i++)
                    if (i->pvalue_binom < Params::getInstance().symtest_pcutoff)
                        id.insert(i - res.begin());
                break;
            case SYMTEST_MAXDIV:
                for (auto i = res.begin(); i != res.end(); i++)
                    if (i->pvalue_maxdiv < Params::getInstance().symtest_pcutoff)
                        id.insert(i - res.begin());
                break;
            default:
                break;
        }
    } else {
        // get non-significant test ID
        switch (Params::getInstance().symtest) {
            case SYMTEST_BINOM:
                for (auto i = res.begin(); i != res.end(); i++)
                    if (i->pvalue_binom >= Params::getInstance().symtest_pcutoff)
                        id.insert(i - res.begin());
                break;
            case SYMTEST_MAXDIV:
                for (auto i = res.begin(); i != res.end(); i++)
                    if (i->pvalue_maxdiv >= Params::getInstance().symtest_pcutoff)
                        id.insert(i - res.begin());
                break;
            default:
                break;
        }
    }
}

double computePValueSMax(vector<SymTestResult> &sym, int start, int step) {
    double orig_max = sym[start].max_stat;
    int count = 0, num = 0;
    for (size_t i = start; i < sym.size(); i += step, num++)
        if (sym[i].max_stat >= orig_max)
            count++;
    return double(count)/num;
    
}

void doSymTest(Alignment *alignment, Params &params) {
    double start_time = getRealTime();
    cout << "Performing matched-pair tests of symmetry...";
    vector<SymTestResult> sym, marsym, intsym;

    size_t num_parts = 1;
    if (alignment->isSuperAlignment())
        num_parts = ((SuperAlignment*)alignment)->partitions.size();
    
    string filename_stat = string(params.out_prefix) + ".symstat.csv";
    ofstream *out_stat = NULL;
    if (params.symtest_stat) {
        out_stat = new ofstream;
        out_stat->open(filename_stat);
        *out_stat
        << "# Statistic values for matched-pair tests of symmetry" << endl
        << "# This file can be read in MS Excel or in R with command:" << endl
        << "#    dat=read.csv('" <<  filename_stat << "',comment.char='#')" << endl
        << "# Columns are comma-separated with following meanings:" << endl
        << "#    ID:     Partition ID" << endl
        << "#    Seq1:   ID of sequence 1 within partition" << endl
        << "#    Seq1:   ID of sequence 2 within partition" << endl
        << "#    Sym:    Statistic for test of symmetry" << endl
        << "#    SymChi: Chi-square p-value for test of symmetry" << endl
        << "#    Mar:    Statistic for test of marginal symmetry" << endl
        << "#    MarChi: Chi-square p-value for marginal test of symmetry" << endl
        << "#    Int:    Statistic for test of internal symmetry" << endl
        << "#    MarChi: Chi-square p-value for internal test of symmetry" << endl
        << "ID,Seq1,Seq2,Sym,SymChi,Mar,MarChi,Int,IntChi" << endl;
        
    }

    sym.resize(num_parts*params.symtest_shuffle);
    marsym.resize(num_parts*params.symtest_shuffle);
    intsym.resize(num_parts*params.symtest_shuffle);

    for (int i = 0; i < params.symtest_shuffle; i++) {
        vector<SymTestStat> *stats = NULL;
        if (params.symtest_stat)
            stats = new vector<SymTestStat>;
        if (i == 0) // original alignment
            alignment->doSymTest(i*num_parts, sym, marsym, intsym, NULL, stats);
        else {
            int *rstream;
            init_random(params.ran_seed+i+1, false, &rstream);
            alignment->doSymTest(i*num_parts, sym, marsym, intsym, rstream, stats);
            finish_random(rstream);
        }
        if ((i+1)*10 % params.symtest_shuffle == 0) {
            cout << " " << (i+1)*100 / params.symtest_shuffle << "%";
            cout.flush();
        }
        if (!stats)
            continue;
        for (auto it = stats->begin(); it != stats->end(); it++) {
            *out_stat << it->part << ',' << it->seq1 << ',' << it->seq2 << ','
            << it->chi2_sym << ',' << it->pval_sym << ','
            << it->chi2_marsym << ',' << it->pval_marsym << ','
            << it->chi2_intsym << ',' << it->pval_intsym << endl;
        }
        delete stats;
    }

    if (out_stat) {
        out_stat->close();
        delete out_stat;
    }
    
    if (params.symtest_shuffle > 1) {
        // compute p-value for s-max approach
        for (int part = 0; part < num_parts; part++) {
            sym[part].pvalue_perm = computePValueSMax(sym, part, num_parts);
            marsym[part].pvalue_perm = computePValueSMax(marsym, part, num_parts);
            intsym[part].pvalue_perm = computePValueSMax(intsym, part, num_parts);
        }
    }

    string filename = string(params.out_prefix) + ".symtest.csv";
    ofstream out;
    out.open(filename);
    out << "# Matched-pair tests of symmetry" << endl
    << "# This file can be read in MS Excel or in R with command:" << endl
    << "#    dat=read.csv('" <<  filename << "',comment.char='#')" << endl
    << "# Columns are comma-separated with following meanings:" << endl
    << "#    Name:    Partition name" << endl
    << "#    SymSig:  Number of significant sequence pairs by test of symmetry" << endl
    << "#    SymNon:  Number of non-significant sequence pairs by test of symmetry" << endl
    << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "#    SymBi:   P-value for binomial test of symmetry" : "#    SymPval: P-value for maximum test of symmetry") << endl;
    if (params.symtest_shuffle > 1)
        out << "#    SymMax:  Maximum of pair statistics by test of symmetry" << endl
            << "#    SymPerm: P-value for permutation test of symmetry" << endl;
    
    out << "#    MarSig:  Number of significant sequence pairs by test of marginal symmetry" << endl
    << "#    MarNon:  Number of non-significant sequence pairs by test of marginal symmetry" << endl
    << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "#    MarBi:   P-value for binomial test of marginal symmetry" : "#    MarPval: P-value for maximum test of marginal symmetry") << endl;
    if (params.symtest_shuffle > 1)
        out << "#    MarMax:  Maximum of pair statistics by test of marginal symmetry" << endl
            << "#    MarPerm: P-value for permutation test of marginal symmetry" << endl;
    out << "#    IntSig:  Number of significant sequence pairs by test of internal symmetry" << endl
    << "#    IntNon:  Number of non-significant sequence pairs by test of internal symmetry" << endl
    << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "#    IntBi:   P-value for binomial test of symmetry" : "#    IntPval: P-value for maximum test of internal symmetry") << endl;
    if (params.symtest_shuffle > 1)
        out << "#    IntMax:  Maximum of pair statistics by test of internal symmetry" << endl
        << "#    IntPerm: P-value for permutation test of internal symmetry" << endl;
    
    out << "Name,SymSig,SymNon," << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "SymBi" : "SymPval")
        << ((params.symtest_shuffle > 1) ? ",SymMax,SymPerm" : "")
        << ",MarSig,MarNon," << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "MarBi" : "MarPval")
        << ((params.symtest_shuffle > 1) ? ",MarMax,MarPerm" : "")
        << ",IntSig,IntNon," << ((Params::getInstance().symtest == SYMTEST_BINOM) ? "IntBi" : "IntPval")
        << ((params.symtest_shuffle > 1) ? ",IntMax,IntPerm" : "") << endl;
    
    if (alignment->isSuperAlignment()) {
        SuperAlignment *saln = (SuperAlignment*)alignment;
        for (int part = 0; part < saln->partitions.size(); part++)
            out << saln->partitions[part]->name << ','
                << sym[part] << ',' << marsym[part] << ','  << intsym[part] << endl;
    } else {
        out << alignment->name << ',' << sym[0] << ',' << marsym[0] << ','  << intsym[0] << endl;
    }

    if (params.symtest_shuffle > 1) {
        for (int part = num_parts; part < sym.size(); part++) {
            sym[part].pvalue_perm = marsym[part].pvalue_perm = intsym[part].pvalue_perm = -1.0;
            out << part % num_parts << ','
            << sym[part] << ',' << marsym[part] << ','  << intsym[part] << endl;
        }
        // erase the rest
        sym.erase(sym.begin()+num_parts, sym.end());
        marsym.erase(marsym.begin()+num_parts, marsym.end());
        intsym.erase(intsym.begin()+num_parts, intsym.end());
    }
    
    out.close();
    cout << " " << getRealTime() - start_time << " seconds" << endl;
    if (params.symtest_stat)
        cout << "SymTest statistics written to " << filename_stat << endl;
    cout << "SymTest results written to " << filename << endl;

    // now filter out partitions
    if (alignment->isSuperAlignment()) {
        set<int> part_id;
        if (params.symtest_remove == 1) {
            // remove bad loci
            if (params.symtest_type == 0)
                getSymTestID(sym, part_id, true);
            else if (params.symtest_type == 1)
                getSymTestID(marsym, part_id, true);
            else
                getSymTestID(intsym, part_id, true);
        } else if (params.symtest_remove == 2) {
            // remove good loci
            if (params.symtest_type == 0)
                getSymTestID(sym, part_id, false);
            else if (params.symtest_type == 1)
                getSymTestID(marsym, part_id, false);
            else
                getSymTestID(intsym, part_id, false);
        }
        if (!part_id.empty()) {
            SuperAlignment *saln = (SuperAlignment*)alignment;
            cout << "Removing " << part_id.size()
            << ((params.symtest_remove == 1)? " bad" : " good") << " partitions (pvalue cutoff = "
            << params.symtest_pcutoff << ")..." << endl;
            if (part_id.size() < alignment->getNSite())
                saln->removePartitions(part_id);
            else
                outError("Can't remove all partitions");
            if (params.aln_output_format == IN_NEXUS) {
                string aln_file = (string)params.out_prefix + ((params.symtest_remove == 1)? ".good.nex" : ".bad.nex");
                alignment->printAlignment(params.aln_output_format, aln_file.c_str());
            } else {
                string aln_file = (string)params.out_prefix + ((params.symtest_remove == 1)? ".good.phy" : ".bad.phy");
                alignment->printAlignment(params.aln_output_format, aln_file.c_str());
                string filename = (string)params.out_prefix + ((params.symtest_remove == 2)? ".good.nex" : ".bad.nex");
                saln->printPartition(filename.c_str(), aln_file.c_str());
            }
        }
    }
    if (params.symtest_only)
        exit(EXIT_SUCCESS);
}

void runPhyloAnalysis(Params &params, Checkpoint *checkpoint, IQTree *&tree, Alignment *&alignment)
{
    checkpoint->putBool("finished", false);
    checkpoint->setDumpInterval(params.checkpoint_dump_interval);

    /****************** read in alignment **********************/
    if (params.partition_file) {
        // Partition model analysis
        if (params.partition_type == TOPO_UNLINKED)
            alignment = new SuperAlignmentUnlinked(params);
        else
            alignment = new SuperAlignment(params);
    } else {
        alignment = createAlignment(params.aln_file, params.sequence_type, params.intype, params.model_name);

        if (params.freq_const_patterns) {
            int orig_nsite = alignment->getNSite();
            alignment->addConstPatterns(params.freq_const_patterns);
            cout << "INFO: " << alignment->getNSite() - orig_nsite << " const sites added into alignment" << endl;
        }

        // Initialize site-frequency model
        if (params.tree_freq_file) {
            if (checkpoint->getBool("finishedSiteFreqFile")) {
                alignment->readSiteStateFreq(((string)params.out_prefix + ".sitefreq").c_str());
                params.print_site_state_freq = WSF_NONE;
                cout << "CHECKPOINT: Site frequency model restored" << endl;
            } else {
                computeSiteFrequencyModel(params, alignment);
                checkpoint->putBool("finishedSiteFreqFile", true);
                checkpoint->dump();
            }
        }
        if (params.site_freq_file) {
            alignment->readSiteStateFreq(params.site_freq_file);
        }
    }

    if (params.symtest) {
        doSymTest(alignment, params);
    }

    if (params.print_aln_info) {
        string site_info_file = string(params.out_prefix) + ".alninfo";
        alignment->printSiteInfo(site_info_file.c_str());
        cout << "Alignment sites statistics printed to " << site_info_file << endl;
    }

    /*************** initialize tree ********************/
    bool isTreeMix = isTreeMixture(params);
    
    if (params.optimize_params_use_hmm && !isTreeMix) {
        outError("option '-hmmster' is only available for tree mixture model");
    }
    
    if (isTreeMix) {
        if (params.optimize_params_use_hmm)
            cout << "HMMSTER ";
        // tree-mixture model
        cout << "Tree-mixture model" << endl;

        if (params.compute_ml_tree_only) {
            outError("option compute_ml_tree_only cannot be set for tree-mixture model");
        }

        // the minimum gamma shape should be greater than MIN_GAMMA_SHAPE_TREEMIX for tree mixture model
        if (params.min_gamma_shape < MIN_GAMMA_SHAPE_TREEMIX) {
            if (params.min_gamma_shape != MIN_GAMMA_SHAPE)
                cout << "The minimum value for Gamma shape is changed to " << MIN_GAMMA_SHAPE_TREEMIX << endl;
            params.min_gamma_shape = MIN_GAMMA_SHAPE_TREEMIX;
        }

        if (params.user_file == NULL) {
            outError("To use tree-mixture model, use an option: -te <newick file with multiple trees>");
        }
        
        // get the number after "+T" for tree-mixture model
        int treeNum = getTreeMixNum(params);
        if (treeNum == 0) {
            tree = newIQTreeMix(params, alignment); // tree mixture model
        } else {
            tree = newIQTreeMix(params, alignment, treeNum); // tree mixture model
        }

    } else {
        tree = newIQTree(params, alignment);
    }

    tree->setCheckpoint(checkpoint);
    if (isTreeMix) {
        ((IQTreeMix*) tree)->setMinBranchLen(params);
    } else if (params.min_branch_length <= 0.0) {
        params.min_branch_length = 1e-6;
        if (!tree->isSuperTree() && tree->getAlnNSite() >= 100000) {
            params.min_branch_length = 0.1 / (tree->getAlnNSite());
            tree->num_precision = max((int)ceil(-log10(Params::getInstance().min_branch_length))+1, 6);
            cout.precision(12);
            cout << "NOTE: minimal branch length is reduced to " << params.min_branch_length << " for long alignment" << endl;
            cout.precision(3);
        }
        // Increase the minimum branch length if PoMo is used.
        if (alignment->seq_type == SEQ_POMO) {
            params.min_branch_length *= alignment->virtual_pop_size * alignment->virtual_pop_size;
            cout.precision(12);
            cout << "NOTE: minimal branch length is increased to " << params.min_branch_length << " because PoMo infers number of mutations and frequency shifts" << endl;
            cout.precision(3);
        }
    }
    // Increase the minimum branch length if PoMo is used.
    if (alignment->seq_type == SEQ_POMO) {
        params.max_branch_length *= alignment->virtual_pop_size * alignment->virtual_pop_size;
        cout.precision(1);
        cout << "NOTE: maximal branch length is increased to " << params.max_branch_length << " because PoMo infers number of mutations and frequency shifts" << endl;
        cout.precision(3);
    }


    if (params.concatenate_aln) {
        Alignment aln(params.concatenate_aln, params.sequence_type, params.intype, params.model_name);
        cout << "Concatenating " << params.aln_file << " with " << params.concatenate_aln << " ..." << endl;
        alignment->concatenateAlignment(&aln);
    }

    if (params.constraint_tree_file) {
        if (isTreeMix) {
            outError("Constraint tree does not work with tree-mixture model");
        }
        cout << "Reading constraint tree " << params.constraint_tree_file << "..." << endl;
        tree->constraintTree.readConstraint(params.constraint_tree_file, alignment->getSeqNames());
        if (params.start_tree == STT_PLL_PARSIMONY)
            params.start_tree = STT_PARSIMONY;
        else if (params.start_tree == STT_BIONJ)
            outError("Constraint tree does not work with -t BIONJ");
        if (params.num_bootstrap_samples || params.gbo_replicates)
            cout << "INFO: Constraint tree will be applied to ML tree and all bootstrap trees." << endl;
    }

    if (params.compute_seq_identity_along_tree) {
        if (isTreeMix) {
            outError("Computing sequence identity does not work with tree-mixture model");
        }
        if (!params.user_file)
            outError("Please supply a user tree file!");
        tree->readTree(params.user_file, params.is_rooted);
        if (!tree->rooted && !params.root) {
            outError("Tree is unrooted, thus you have to specify a root with -o option");
        }
        tree->setAlignment(tree->aln);
        if (!tree->rooted)
            tree->setRootNode(params.root);
        tree->computeSeqIdentityAlongTree();
        if (verbose_mode >= VB_MED)
            tree->drawTree(cout);
        string out_tree = (string)params.out_prefix + ".seqident_tree";
        tree->printTree(out_tree.c_str());
        cout << "Tree with sequence identity printed to " << out_tree << endl;
    } else if (params.aln_output) {
        if (isTreeMix) {
            outError("Coverting alignment feature does not work with tree-mixture model");
        }
        /************ convert alignment to other format and write to output file *************/
        convertAlignment(params, tree);
    } else if (params.gbo_replicates > 0 && params.user_file && params.second_tree) {
        // run one of the UFBoot analysis
//        runGuidedBootstrap(params, alignment, *tree);
        outError("Obsolete feature");
    } else if (params.avh_test) {
        // run one of the wondering test for Arndt
//        runAvHTest(params, alignment, *tree);
        outError("Obsolete feature");
    } else if (params.bootlh_test) {
        // run Arndt's plot of tree likelihoods against bootstrap alignments
//        runBootLhTest(params, alignment, *tree);
        outError("Obsolete feature");
    } else if (params.num_bootstrap_samples == 0) {
    /********************************************************************************
                    THE MAIN MAXIMUM LIKELIHOOD TREE RECONSTRUCTION
     ********************************************************************************/
        ModelCheckpoint *model_info = new ModelCheckpoint;
        alignment->checkGappySeq(params.remove_empty_seq);

        // remove identical sequences
        if (params.ignore_identical_seqs) {
            tree->removeIdenticalSeqs(params);
            if (tree->removed_seqs.size() > 0 && MPIHelper::getInstance().isMaster() && (params.suppress_output_flags & OUT_UNIQUESEQ) == 0) {
                string filename = (string)params.out_prefix + ".uniqueseq.phy";
                tree->aln->printAlignment(params.aln_output_format, filename.c_str());
                cout << endl << "For your convenience alignment with unique sequences printed to " << filename << endl;
            }
        }
        alignment = NULL; // from now on use tree->aln instead

        startTreeReconstruction(params, tree, *model_info);
        // call main tree reconstruction
        if (params.num_runs == 1) {
            runTreeReconstruction(params, tree);
        } else {
            runMultipleTreeReconstruction(params, tree->aln, tree);
        }
        
        if (params.ancestral_site_concordance)
            tree->computeAllAncestralSiteConcordance();
        
        if (MPIHelper::getInstance().isMaster()) {
            reportPhyloAnalysis(params, *tree, *model_info);
        }

        // reinsert identical sequences
        if (tree->removed_seqs.size() > 0) {
            // BUG FIX: dont use reinsertIdenticalSeqs anymore
            tree->insertTaxa(tree->removed_seqs, tree->twin_seqs);
            tree->printResultTree();
        }
        delete model_info;
        
        if (params.dating_method != "") {
            doTimeTree(tree);
        }

    } else {
        // the classical non-parameter bootstrap (SBS)
//        if (params.model_name.find("LINK") != string::npos || params.model_name.find("MERGE") != string::npos)
//            outError("-m TESTMERGE is not allowed when doing standard bootstrap. Please first\nfind partition scheme on the original alignment and use it for bootstrap analysis");
        if (alignment->getNSeq() < 4)
            outError("It makes no sense to perform bootstrap with less than 4 sequences.");
        runStandardBootstrap(params, alignment, tree);
    }

//    if (params.upper_bound) {
//            UpperBounds(&params, alignment, tree);
//    }

    if(verbose_mode >= VB_MED){
        if(tree->isSuperTree() && params.partition_type != BRLEN_OPTIMIZE){
            ((PhyloSuperTreePlen*) tree)->printNNIcasesNUM();
        }
    }

    checkpoint->putBool("finished", true);
    checkpoint->dump(true);
}

void runPhyloAnalysis(Params &params, Checkpoint *checkpoint) {
    bool runCMapleAlg = false;
    // check and run CMaple algorithm (if users want to do so)
    if (params.inference_alg != ALG_IQ_TREE)
        runCMapleAlg = runCMaple(params);
        
    // run IQ-TREE algorithm, by default
    if (!runCMapleAlg)
    {
        IQTree *tree;
        Alignment *alignment;
        
        runPhyloAnalysis(params, checkpoint, tree, alignment);
        
        // 2015-09-22: bug fix, move this line to before deleting tree
        alignment = tree->aln;
        delete tree;
        // BUG FIX: alignment can be changed, should delete tree->aln instead
        // 2015-09-22: THIS IS STUPID: after deleting tree, one cannot access tree->aln anymore
        //    alignment = tree->aln;
        delete alignment;
    }
}

bool runCMaple(Params &params)
{    
#if !defined(USE_CMAPLE)
    outWarning("This version was not compiled with CMAPLE integrated. Running IQ-TREE algorithm...");
    return false;
#else
    // Validate the input aln
    if (!params.aln_file) outError("Please supply an input alignment via '-s <alignment_file>");
    
    try
    {
        // record the start time
        auto start = getRealTime();
        
        // Dummy variables
        std::string aln_path(params.aln_file);
        const std::string prefix(params.out_prefix ? params.out_prefix : aln_path);
        const std::string output_treefile = prefix + ".treefile";
        const cmaple::Tree::TreeType tree_format = cmaple::Tree::parseTreeType(params.tree_format_str);
        
        // Check whether output file is already exists
        if (!params.ignore_checkpoint && fileExists(output_treefile))
            outError("File " + output_treefile + " already exists. Use `-redo` to redo the inference.\n");
        
        // Parse the sequence type (if specified)
        const cmaple::SeqRegion::SeqType seq_type = params.sequence_type ? cmaple::SeqRegion::parseSeqType(std::string(params.sequence_type)) : cmaple::SeqRegion::SEQ_AUTO;
        // Validate the seq_type
        if (seq_type == cmaple::SeqRegion::SEQ_UNKNOWN)
            throw std::invalid_argument("Unknown/Unsupported SeqType " + std::string(params.sequence_type));
        
        // Initialize an Alignment
        // Retrieve the reference genome (if specified) from an alignment -> this feature has not yet exposed to APIs -> should be refactoring later
        std::string ref_seq = "";
        if (params.root_ref_seq_aln.length() && params.root_ref_seq_name.length())
        {
            cmaple::Alignment aln_tmp;
            ref_seq = aln_tmp.readRefSeq(params.root_ref_seq_aln, params.root_ref_seq_name);
        }
        const cmaple::Alignment::InputType aln_format = cmaple::Alignment::parseAlnFormat(params.in_aln_format_str);
        // Validate the aln_format
        if (aln_format == cmaple::Alignment::IN_UNKNOWN)
            throw std::invalid_argument("Unknown alignment format " + params.in_aln_format_str);
        cmaple::Alignment aln(aln_path, ref_seq, aln_format, seq_type);
        
        // check if CMaple is suitable for the input alignment
        if (!cmaple::isEffective(aln))
        {
            std::cout << "The input alignment is too divergent, which is inappropriate for [C]Maple algorithm." <<std::endl;
            
            // if users force running CMAPLE -> show a warning
            if (params.inference_alg == ALG_CMAPLE)
            {
                std::cout << "We highly recommend to use the IQ-TREE inference algorithm for this analysis."
                << " Please stop and re-run WITHOUT `--pathogen-force`!" << std::endl;
            }
            // otherwise, users allow us to choose the inference algorithm -> choose IQ-TREE
            else
            {
                params.inference_alg = ALG_IQ_TREE;
                std::cout << "Running IQ-TREE algorithm..." << std::endl;
                return false;
            }
        }
        // otherwise, it's suitable to run CMAPLE algorithm here
        else
            params.inference_alg = ALG_CMAPLE;
        
        // run CMAPLE algorithm
        if (params.inference_alg == ALG_CMAPLE)
        {
            std::cout << "Running [C]MAPLE algorithm..." << std::endl;
            
            // If running multi-processes -> only the master works
            if (MPIHelper::getInstance().getNumProcesses() > 1 && MPIHelper::getInstance().getProcessID() > 0)
                return true;
            
            // Initialize a Model
            cmaple::ModelBase::SubModel sub_model = params.model_name.length() ? cmaple::ModelBase::parseModel(params.model_name) : cmaple::ModelBase::DEFAULT;
            // Validate the sub_model
            if (sub_model == cmaple::ModelBase::UNKNOWN)
            {
                std::cout << "Unknown/Unsupported model '" + params.model_name + "'. Using the default model instead (i.e., GTR for DNA and LG for Protein data)" << std::endl;
                sub_model = cmaple::ModelBase::DEFAULT;
            }
            cmaple::Model model(sub_model, aln.getSeqType());
            
            // Initialize a Tree
            const std::string input_treefile(params.user_file ? params.user_file : "");
            cmaple::Tree tree(&aln, &model, input_treefile, (params.fixed_branch_length == BRLEN_FIX), cmaple::ParamsBuilder().build());
            
            // Infer a phylogenetic tree
            const cmaple::Tree::TreeSearchType tree_search_type = cmaple::Tree::parseTreeSearchType(params.tree_search_type_str);
            std::ostream null_stream(0);
            std::ostream& out_stream = cmaple::verbose_mode >= cmaple::VB_MED ? std::cout : null_stream;
            tree.infer(tree_search_type, params.shallow_tree_search, out_stream);
            
            // Compute branch supports (if users want to do so)
            if (params.aLRT_replicates)
            {
                // if users don't input a tree file, always allow CMaple to replace the ML tree by a higher-likelihood tree (if found)
                bool allow_replacing_ML_tree = true;
                // if users input a tree -> depend on the setting in params (false ~ don't allow replacing (by default)
                if (input_treefile.length())
                    allow_replacing_ML_tree = params.allow_replace_input_tree;
                
                tree.computeBranchSupport(params.num_threads, params.aLRT_replicates, 0.1, allow_replacing_ML_tree, out_stream);
                
                // write the tree file with branch supports
                /*ofstream out_tree_branch_supports = ofstream(prefix + ".aLRT_SH.treefile");
                out_tree_branch_supports << tree.exportNewick(tree_format, true);
                out_tree_branch_supports.close();*/
            }
            
            // If needed, apply some minor changes (collapsing zero-branch leaves into less-info sequences, re-estimating model parameters) to make the processes of outputting then re-inputting a tree result in a consistent tree
            if (params.make_consistent)
                tree.makeTreeInOutConsistent();
            
            // output log-likelihood of the tree
            if (cmaple::verbose_mode > cmaple::VB_QUIET)
                std::cout << std::setprecision(10) << "Tree log likelihood: " << tree.computeLh() << std::endl;
            
            // Write the normal tree file
            ofstream out = ofstream(output_treefile);
            out << tree.exportNewick(tree_format);
            out.close();
                
            // Show model parameters
            if (cmaple::verbose_mode > cmaple::VB_QUIET)
            {
                cmaple::Model::ModelParams model_params = model.getParams();
                std::cout << "\nMODEL: " + model_params.model_name + "\n";
                std::cout << "\nROOT FREQUENCIES\n";
                std::cout << model_params.state_freqs;
                std::cout << "\nMUTATION MATRIX\n";
                std::cout << model_params.mut_rates << std::endl;
            }
                
            // Show information about output files
            std::cout << "Analysis results written to:" << std::endl;
            std::cout << "Maximum-likelihood tree:       " << output_treefile << std::endl;
            /*if (params.aLRT_replicates)
                std::cout << "Tree with aLRT-SH values:      " << prefix + ".aLRT_SH.treefile" << std::endl;*/
            std::cout << "Screen log file:               " << prefix + ".log" << std::endl << std::endl;
            
            // show runtime
            auto end = getRealTime();
            if (cmaple::verbose_mode > cmaple::VB_QUIET)
                cout << "CMAPLE Runtime: " << end - start << "s" << endl;
        }
    }
    catch (std::invalid_argument e)
    {
        outError(e.what());
    }
    catch (std::logic_error e)
    {
        outError(e.what());
    }
    catch (ios::failure e)
    {
        outError(e.what());
    }
    
    // return true, by default
    return true;
#endif
}

/**
    Perform separate tree reconstruction when tree topologies
    are unlinked between partitions
 */
void runUnlinkedPhyloAnalysis(Params &params, Checkpoint *checkpoint) {
    SuperAlignment *super_aln;
    
    ASSERT(params.partition_file);
    
    /****************** read in alignment **********************/
    // Partition model analysis
    super_aln = new SuperAlignmentUnlinked(params);
    PhyloSuperTree *super_tree = new PhyloSuperTree(super_aln);
 
    /**** do separate tree reconstruction for each partition ***/
    
    MTreeSet part_trees;
    
    if (params.user_file) {
        // reading user tree file for all partitions
        bool is_rooted = false;
        part_trees.readTrees(params.user_file, is_rooted, 0, super_aln->partitions.size());
        if (is_rooted)
            outError("Rooted trees not allowed: ", params.user_file);
        if (part_trees.size() != super_aln->partitions.size())
            outError("User tree file does not have the same number of trees as partitions");
        params.user_file = NULL;
    }

    ModelCheckpoint *model_info = new ModelCheckpoint;
    int part = 0;
    for (auto alnit = super_aln->partitions.begin(); alnit != super_aln->partitions.end(); alnit++, part++) {
        
        checkpoint->startStruct((*alnit)->name);

        // allocate heterotachy tree if neccessary
        int pos = posRateHeterotachy((*alnit)->model_name);
        IQTree *tree;
        
        if (params.num_mixlen > 1) {
            tree = new PhyloTreeMixlen((*alnit), params.num_mixlen);
        } else if (pos != string::npos) {
            tree = new PhyloTreeMixlen((*alnit), 0);
        } else
            tree = new IQTree((*alnit));

        tree->setCheckpoint(checkpoint);
        if (checkpoint->getBool("finished")) {
            tree->restoreCheckpoint();
        } else {
            if (!part_trees.empty())
                tree->copyTree(part_trees[part]);

            startTreeReconstruction(params, tree, *model_info);
            // call main tree reconstruction
            if (params.num_runs == 1)
                runTreeReconstruction(params, tree);
            else
                runMultipleTreeReconstruction(params, tree->aln, tree);
            checkpoint->putBool("finished", true);
            checkpoint->dump();
        }

        super_tree->at(part)->copyTree(tree);
        
        delete tree;
        checkpoint->endStruct();
    }
    
    IQTree *iqtree = super_tree;
    super_tree->setCheckpoint(checkpoint);
    startTreeReconstruction(params, iqtree, *model_info);
    runTreeReconstruction(params, iqtree);
    if (MPIHelper::getInstance().isMaster())
        reportPhyloAnalysis(params, *iqtree, *model_info);

    delete super_tree;
    delete super_aln;
    delete model_info;
}

void assignBranchSupportNew(Params &params) {
    if (!params.user_file)
        outError("No target tree file provided");
    if (params.num_threads == 0)
        outError("-nt AUTO is not supported for concordance factor analysis, please specify no. cores");
    PhyloTree *tree;
    Alignment *aln = NULL;
    if (params.site_concordance) {
        if (!params.aln_file && !params.partition_file)
            outError("Please provide an alignment (-s) or partition file");
        if (params.partition_file) {
            params.compute_seq_composition = false;
            aln = new SuperAlignment(params);
            tree = new PhyloSuperTree((SuperAlignment*)aln);
        } else {
            aln = createAlignment(params.aln_file, params.sequence_type, params.intype, params.model_name);
            tree = new PhyloTree;
        }
    } else {
        tree = new PhyloTree;
    }
    tree->setParams(&params);

    cout << "Reading tree " << params.user_file << " ..." << endl;
    bool rooted = params.is_rooted;
    tree->readTree(params.user_file, rooted);
    cout << ((tree->rooted) ? "rooted" : "un-rooted") << " tree with "
        << tree->leafNum - tree->rooted << " taxa and " << tree->branchNum << " branches" << endl;

    // 2018-12-13: move initialisation to fix rooted vs unrooted tree
    if (params.site_concordance) {
        tree->setAlignment(aln);
        if (tree->isSuperTree())
            ((PhyloSuperTree*)tree)->mapTrees();
    }
    
    BranchVector branches;
    tree->getInnerBranches(branches);
    BranchVector::iterator brit;
    for (brit = branches.begin(); brit != branches.end(); brit++) {
        Neighbor *branch = brit->second->findNeighbor(brit->first);
        string label = brit->second->name;
        if (!label.empty())
            PUT_ATTR(branch, label);
    }
    
    map<string,string> meanings;
    
    if (!params.treeset_file.empty()) {
        bool rooted = params.is_rooted;
        MTreeSet trees(params.treeset_file.c_str(), rooted, params.tree_burnin, params.tree_max_count);
        double start_time = getRealTime();
        cout << "Computing gene concordance factor..." << endl;
        tree->computeGeneConcordance(trees, meanings);
        if (params.internode_certainty)
            tree->computeQuartetConcordance(trees);
        cout << getRealTime() - start_time << " sec" << endl;
    }
    if (params.site_concordance) {
        cout << "Computing site concordance factor..." << endl;
        double start_time = getRealTime();
        tree->computeSiteConcordance(meanings);
        cout << getRealTime() - start_time << " sec" << endl;
        delete aln;
    }
    string prefix = (params.out_prefix) ? params.out_prefix : params.user_file;
    string str = prefix + ".cf.tree";
    tree->printTree(str.c_str(), WT_BR_LEN + WT_NEWLINE);
    cout << "Tree with concordance factors written to " << str << endl;
    str = prefix + ".cf.tree.nex";
    string filename = prefix + ".cf.stat";
    tree->printNexus(str, WT_BR_LEN, "See " + filename + " for branch annotation meanings." +
                     " This file is best viewed in FigTree.");
    cout << "Annotated tree (best viewed in FigTree) written to " << str << endl;
    if (verbose_mode >= VB_DEBUG)
        tree->drawTree(cout);
    str = prefix + ".cf.branch";
    tree->printTree(str.c_str(), WT_BR_LEN + WT_INT_NODE + WT_NEWLINE);
    cout << "Tree with branch IDs written to " << str << endl;
    ofstream out;
    out.open(filename.c_str());
    out << "# Concordance factor statistics" << endl
        << "# This file can be read in MS Excel or in R with command:" << endl
        << "#   tab=read.table('" <<  filename << "',header=TRUE)" << endl
        << "# Columns are tab-separated with following meaning:" << endl
        << "#   ID: Branch ID" << endl;
    map<string,string>::iterator mit;
    for (mit = meanings.begin(); mit != meanings.end(); mit++)
        if (mit->first[0] != '*')
            out << "#   " << mit->first << ": " << mit->second << endl;
    out << "#   Label: Existing branch label" << endl;
    out << "#   Length: Branch length" << endl;
    for (mit = meanings.begin(); mit != meanings.end(); mit++)
        if (mit->first[0] == '*')
            out << "# " << mit->first << ": " << mit->second << endl;
    out << "ID";
    for (mit = meanings.begin(); mit != meanings.end(); mit++)
        if (mit->first[0] != '*')
            out << "\t" << mit->first;
    out << "\tLabel\tLength" << endl;
    for (brit = branches.begin(); brit != branches.end(); brit++) {
        Neighbor *branch = brit->second->findNeighbor(brit->first);
        int ID = brit->second->id;
        out << ID;
        for (mit = meanings.begin(); mit != meanings.end(); mit++) {
            if (mit->first[0] == '*')
                continue; // ignore NOTES
            out << '\t';
            string val;
            if (branch->getAttr(mit->first, val))
                out << val;
            else
                out << "NA";
        }
        double length = branch->length;
        string label;
        GET_ATTR(branch, label);
        out << '\t' << label << '\t' << length << endl;
    }
    out.close();
    cout << "Concordance factors per branch printed to " << filename << endl;
    
    if (params.print_cf_quartets) {
        filename = prefix + ".cf.quartet";
        out.open(filename);
        out << "# Site concordance factor for all resampled quartets (with replacement)" << endl
            << "# This file can be read in MS Excel or in R with command:" << endl
            << "#   tab=read.table('" <<  filename << "',header=TRUE)" << endl
            << "# Columns are tab-separated with following meaning:" << endl
            << "#   ID: Branch ID" << endl
            << "#   QuartID: Quartet ID" << endl
            << "#   Seq1: ID of sequence 1 on 'left' side of the branch" << endl
            << "#   Seq2: ID of sequence 2 on 'left' side of the branch" << endl
            << "#   Seq3: ID of sequence 3 on 'right' side of the branch" << endl
            << "#   Seq4: ID of sequence 4 on 'right' side of the branch" << endl
            << "#   qCF: Fraction of concordant sites supporting quartet Seq1,Seq2|Seq3,Seq4 (=qCF_N/qN)" << endl
            << "#   qCF_N: Number of concordant sites supporting quartet Seq1,Seq2|Seq3,Seq4" << endl
            << "#   qDF1: Fraction of discordant sites supporting quartet Seq1,Seq3|Seq2,Seq4  (=qDF1_N/qN)" << endl
            << "#   qDF1_N: Number of discordant sites supporting quartet Seq1,Seq3|Seq2,Seq4" << endl
            << "#   qDF2: Fraction of discordant sites supporting quartet Seq1,Seq4|Seq2,Seq3 (=qDF2_N/qN)" << endl
            << "#   qDF2_N: Number of discordant sites supporting quartet Seq1,Seq4|Seq2,Seq3" << endl
            << "#   qN: Number of decisive sites with four taxa Seq1,Seq2,Seq3,Seq4 (=qCF_N+qDF1_N+qDF2_N)" << endl
            << "ID\tQuartID\tSeq1\tSeq2\tSeq3\tSeq4\tqCF\tqCF_N\tqDF1\tqDF1_N\tqDF2\tqDF2_N\tqN" << endl;
        for (brit = branches.begin(); brit != branches.end(); brit++) {
            Neighbor *branch = brit->second->findNeighbor(brit->first);
            int ID = brit->second->id;
            for (int qid = 0; ; qid++) {
                string qstr;
                if (branch->attributes.find("q" + convertIntToString(qid)) == branch->attributes.end())
                    break;
                out << ID << '\t' << qid+1 << '\t' << branch->attributes["q" + convertIntToString(qid)] << endl;
            }
        }
        out.close();
        cout << "Site concordance factors for quartets printed to " << filename << endl;
    }
    
    outWarning("You probably want the --scfl option. The site concordance factor\n implemented with the --scf option is based on parsimony (described here:\n https://doi.org/10.1093/molbev/msaa106). It has since been superseded by a more\n accurate likelihood-based approach which is implemented in the --scfl option, and\n is described in the paper \"Updated site concordance factors minimize effects of\n homoplasy and taxon sampling\" by Yu et al.. Please see the tutorial here for more\n information: http://www.iqtree.org/doc/Concordance-Factor");
    
    if (!params.site_concordance_partition)
        return;
    
    // print concordant/discordant gene trees
    filename = prefix + ".cf.stat_tree";
    out.open(filename);
    out << "# Concordance factor statistics for decisive trees" << endl
    << "# This file can be read in MS Excel or in R with command:" << endl
    << "#   tab2=read.table('" <<  filename << "',header=TRUE)" << endl
    << "# Columns are tab-separated with following meaning:" << endl
    << "#   ID: Branch ID" << endl
    << "#   TreeID: Tree ID" << endl
    << "#   gC: 1/0 if tree is concordant/discordant with branch" << endl
    << "#   gD1: 1/0 if NNI-1 tree is concordant/discordant with branch" << endl
    << "#   gD2: 1/0 if NNI-2 tree is concordant/discordant with branch" << endl
    << "# NOTE: NA means that tree is not decisive for branch" << endl
    << "ID\tTreeID\tgC\tgD1\tgD2" << endl;
    for (brit = branches.begin(); brit != branches.end(); brit++) {
        Neighbor *branch = brit->second->findNeighbor(brit->first);
        int ID = brit->second->id;
        for (int part = 1; ; part++) {
            string gC, gD1, gD2;
            if (!branch->getAttr("gC" + convertIntToString(part), gC))
                break;
            branch->getAttr("gD1" + convertIntToString(part), gD1);
            branch->getAttr("gD2" + convertIntToString(part), gD2);
            out << ID << '\t' << part << '\t' << gC << '\t' << gD1 << '\t' << gD2 << endl;
        }
    }
    out.close();
    cout << "Concordance factors per branch and tree printed to " << filename << endl;
    
    if (!params.site_concordance_partition || !tree->isSuperTree())
        return;
    // print partition-wise concordant/discordant sites
    filename = prefix + ".cf.stat_loci";
    out.open(filename);
    out << "# Concordance factor statistics for loci" << endl
    << "# This file can be read in MS Excel or in R with command:" << endl
    << "#   tab2=read.table('" <<  filename << "',header=TRUE)" << endl
    << "# Columns are tab-separated with following meaning:" << endl
    << "#   ID: Branch ID" << endl
    << "#   PartID: Locus ID" << endl
    << "#   sC: Number of concordant sites averaged over " << params.site_concordance << " quartets" << endl
    << "#   sD1: Number of discordant sites for alternative quartet 1" << endl
    << "#   sD2: Number of discordant sites for alternative quartet 2" << endl
    << "# NOTE: NA means that locus is not decisive for branch" << endl
    << "ID\tPartID\tsC\tsD1\tsD2" << endl;
    for (brit = branches.begin(); brit != branches.end(); brit++) {
        Neighbor *branch = brit->second->findNeighbor(brit->first);
        int ID = brit->second->id;
        for (int part = 1; ; part++) {
            string sC, sD1, sD2;
            if (!branch->getAttr("sC" + convertIntToString(part), sC))
                break;
            if (!branch->getAttr("sD1" + convertIntToString(part), sD1))
                break;
            if (!branch->getAttr("sD2" + convertIntToString(part), sD2))
                break;
            out << ID << '\t' << part << '\t' << sC << '\t' << sD1 << '\t' << sD2 << endl;
        }
    }
    out.close();
    cout << "Concordance factors per branch and locus printed to " << filename << endl;
}



/**
 * assign split occurence frequencies from a set of input trees onto a target tree
 * NOTE: input trees must have the same taxon set
 * @param input_trees file containing NEWICK tree strings
 * @param burnin number of beginning trees to discard
 * @param max_count max number of trees to read in
 * @param target_tree the target tree
 * @param rooted TRUE if trees are rooted, false for unrooted trees
 * @param output_file file name to write output tree with assigned support values
 * @param out_prefix prefix of output file
 * @param mytree (OUT) resulting tree with support values assigned from target_tree
 * @param tree_weight_file file containing INTEGER weights of input trees
 * @param params program parameters
 */
void assignBootstrapSupport(const char *input_trees, int burnin, int max_count,
        const char *target_tree, bool rooted, const char *output_tree,
        const char *out_prefix, MExtTree &mytree, const char* tree_weight_file,
        Params *params) {
    bool myrooted = rooted;
    // read the tree file
    cout << "Reading tree " << target_tree << " ..." << endl;
    mytree.init(target_tree, myrooted);
    if (mytree.rooted)
        cout << "rooted tree detected" << endl;
    else
        cout << "unrooted tree detected" << endl;
    // reindex the taxa in the tree to aphabetical names
    NodeVector taxa;
    mytree.getTaxa(taxa);
    sort(taxa.begin(), taxa.end(), nodenamecmp);
    int i = 0;
    for (NodeVector::iterator it = taxa.begin(); it != taxa.end(); it++) {
        (*it)->id = i++;
    }

    /*
     string filename = params.boot_trees;
     filename += ".nolen";
     boot_trees.printTrees(filename.c_str(), false);
     return;
     */
    SplitGraph sg;
    SplitIntMap hash_ss;
    // make the taxa name
    vector<string> taxname;
    taxname.resize(mytree.leafNum);
    mytree.getTaxaName(taxname);

    // read the bootstrap tree file
    double scale = 100.0;
    if (params->scaling_factor > 0)
        scale = params->scaling_factor;

    MTreeSet boot_trees;
    if (params && detectInputFile(input_trees) == IN_NEXUS) {
        sg.init(*params);
        for (SplitGraph::iterator it = sg.begin(); it != sg.end(); it++)
            hash_ss.insertSplit((*it), (*it)->getWeight());
        StrVector sgtaxname;
        sg.getTaxaName(sgtaxname);
        i = 0;
        for (StrVector::iterator sit = sgtaxname.begin();
                sit != sgtaxname.end(); sit++, i++) {
            Node *leaf = mytree.findLeafName(*sit);
            if (!leaf)
                outError("Tree does not contain taxon ", *sit);
            leaf->id = i;
        }
        scale /= sg.maxWeight();
    } else {
        myrooted = rooted;
        boot_trees.init(input_trees, myrooted, burnin, max_count,
                        tree_weight_file);
        if (mytree.rooted != boot_trees.isRooted())
            outError("Target tree and tree set have different rooting");
        if (boot_trees.equal_taxon_set) {
            boot_trees.convertSplits(taxname, sg, hash_ss, SW_COUNT, -1, params->support_tag);
            scale /= boot_trees.sumTreeWeights();
        }
    }
    //sg.report(cout);
    if (!sg.empty()) {
        cout << "Rescaling split weights by " << scale << endl;
        if (params->scaling_factor < 0)
            sg.scaleWeight(scale, true);
        else {
            sg.scaleWeight(scale, false, params->numeric_precision);
        }

        cout << sg.size() << " splits found" << endl;
    }
    // compute the percentage of appearance
    //    printSplitSet(sg, hash_ss);
    //sg.report(cout);
    cout << "Creating " << RESAMPLE_NAME << " support values..." << endl;
    if (!sg.empty())
        mytree.createBootstrapSupport(taxname, boot_trees, hash_ss, params->support_tag);
    else {
        //mytree.createBootstrapSupport(boot_trees);
        cout << "Unequal taxon sets, rereading trees..." << endl;
        DoubleVector rfdist;
        mytree.computeRFDist(input_trees, rfdist, 1);
    }
    
    //mytree.scaleLength(100.0/boot_trees.size(), true);
    string out_file;
    if (output_tree)
        out_file = output_tree;
    else {
        if (out_prefix)
            out_file = out_prefix;
        else
            out_file = target_tree;
        out_file += ".suptree";
    }

    mytree.printTree(out_file.c_str());
    cout << "Tree with assigned support written to " << out_file
            << endl;
    /*
    if (out_prefix)
        out_file = out_prefix;
    else
        out_file = target_tree;
    out_file += ".supval";
    mytree.writeInternalNodeNames(out_file);

    cout << "Support values written to " << out_file << endl;
    */
}

void computeConsensusTree(const char *input_trees, int burnin, int max_count,
        double cutoff, double weight_threshold, const char *output_tree,
        const char *out_prefix, const char *tree_weight_file, Params *params) {
    bool rooted = false;

    // read the bootstrap tree file
    /*
     MTreeSet boot_trees(input_trees, rooted, burnin, tree_weight_file);
     string first_taxname = boot_trees.front()->root->name;
     //if (params.root) first_taxname = params.root;

     SplitGraph sg;

     boot_trees.convertSplits(sg, cutoff, SW_COUNT, weight_threshold);*/

    //sg.report(cout);
    SplitGraph sg;
    SplitIntMap hash_ss;
    // make the taxa name
    //vector<string> taxname;
    //taxname.resize(mytree.leafNum);
    //mytree.getTaxaName(taxname);

    // read the bootstrap tree file
    double scale = 100.0;
    if (params->scaling_factor > 0)
        scale = params->scaling_factor;

    MTreeSet boot_trees;
    if (params && detectInputFile(input_trees) == IN_NEXUS) {
        char *user_file = params->user_file;
        params->user_file = (char*) input_trees;
        params->split_weight_summary = SW_COUNT; // count number of splits
        sg.init(*params);
        params->user_file = user_file;
        for (SplitGraph::iterator it = sg.begin(); it != sg.end();)
            if ((*it)->getWeight() > weight_threshold) {
                hash_ss.insertSplit((*it), (*it)->getWeight());
                it++;
            } else {
                // delete the split
                if (it != sg.end()-1) {
                    *(*it) = (*sg.back());
                }
                delete sg.back();
                sg.pop_back();
            }
        /*        StrVector sgtaxname;
         sg.getTaxaName(sgtaxname);
         i = 0;
         for (StrVector::iterator sit = sgtaxname.begin(); sit != sgtaxname.end(); sit++, i++) {
         Node *leaf = mytree.findLeafName(*sit);
         if (!leaf) outError("Tree does not contain taxon ", *sit);
         leaf->id = i;
         }*/
        scale /= sg.maxWeight();
    } else {
        boot_trees.init(input_trees, rooted, burnin, max_count,
                tree_weight_file);
        boot_trees.convertSplits(sg, cutoff, SW_COUNT, weight_threshold);
        scale /= boot_trees.sumTreeWeights();
        cout << sg.size() << " splits found" << endl;
    }
    //sg.report(cout);
    if (verbose_mode >= VB_MED)
        cout << "Rescaling split weights by " << scale << endl;
    if (params->scaling_factor < 0)
        sg.scaleWeight(scale, true);
    else {
        sg.scaleWeight(scale, false, params->numeric_precision);
    }



    //cout << "Creating greedy consensus tree..." << endl;
    MTree mytree;
    SplitGraph maxsg;
    sg.findMaxCompatibleSplits(maxsg);

    if (verbose_mode >= VB_MAX)
        maxsg.saveFileStarDot(cout);
    //cout << "convert compatible split system into tree..." << endl;
    mytree.convertToTree(maxsg);
    //cout << "done" << endl;
    if (!mytree.rooted) {
        string taxname;
        if (params->root)
            taxname = params->root;
        else
            taxname = sg.getTaxa()->GetTaxonLabel(0);
        Node *node = mytree.findLeafName(taxname);
        if (node)
            mytree.root = node;
    }
    // mytree.scaleLength(100.0 / boot_trees.sumTreeWeights(), true);

    // mytree.getTaxaID(maxsg.getSplitsBlock()->getCycle());
    //maxsg.saveFile(cout);

    string out_file;

    if (output_tree)
        out_file = output_tree;
    else {
        if (out_prefix)
            out_file = out_prefix;
        else
            out_file = input_trees;
        out_file += ".contree";
    }

//    if (removed_seqs.size() > 0)
//        mytree.insertTaxa(removed_seqs, twin_seqs);

    mytree.printTree(out_file.c_str(), WT_BR_CLADE);
    cout << "Consensus tree written to " << out_file << endl;

    if (output_tree)
        out_file = output_tree;
    else {
        if (out_prefix)
            out_file = out_prefix;
        else
            out_file = input_trees;
        out_file += ".splits";
    }

    //sg.scaleWeight(0.01, false, 4);
    if (params->print_splits_file) {
        sg.saveFile(out_file.c_str(), IN_OTHER, true);
        cout << "Non-trivial split supports printed to star-dot file " << out_file << endl;
    }

}

void computeConsensusNetwork(const char *input_trees, int burnin, int max_count,
        double cutoff, int weight_summary, double weight_threshold, const char *output_tree,
        const char *out_prefix, const char* tree_weight_file) {
    bool rooted = false;

    // read the bootstrap tree file
    MTreeSet boot_trees(input_trees, rooted, burnin, max_count,
            tree_weight_file);

    SplitGraph sg;
    //SplitIntMap hash_ss;

    boot_trees.convertSplits(sg, cutoff, weight_summary, weight_threshold);

    string out_file;

    if (output_tree)
        out_file = output_tree;
    else {
        if (out_prefix)
            out_file = out_prefix;
        else
            out_file = input_trees;
        out_file += ".nex";
    }

    sg.saveFile(out_file.c_str(), IN_NEXUS);
    cout << "Consensus network printed to " << out_file << endl;

    if (output_tree)
        out_file = output_tree;
    else {
        if (out_prefix)
            out_file = out_prefix;
        else
            out_file = input_trees;
        out_file += ".splits";
    }
    if (verbose_mode >= VB_MED) {
        sg.saveFile(out_file.c_str(), IN_OTHER, true);
        cout << "Non-trivial split supports printed to star-dot file " << out_file << endl;
    }

}

void runRootstrap(Params &params) {
    if (!params.user_file)
        outError("No target tree file provided");
    if (params.treeset_file.empty())
        outError("No tree set file provided");
    IQTree tree;
    tree.setParams(&params);

    cout << "Reading tree " << params.user_file << " ..." << endl;
    bool rooted = params.is_rooted;
    tree.readTree(params.user_file, rooted);

    cout << ((tree.rooted) ? "rooted" : "un-rooted") << " tree with "
        << tree.leafNum - tree.rooted << " taxa and " << tree.branchNum << " branches" << endl;
    
    if (!tree.rooted && !params.root)
        outError("For unrooted tree please provide an outgroup via -o option");

    
    // move the node name into branch name to avoid mis-labelling
    BranchVector branches;
    tree.getInnerBranches(branches);
    BranchVector::iterator brit;
    for (brit = branches.begin(); brit != branches.end(); brit++) {
        Neighbor *branch1 = brit->second->findNeighbor(brit->first);
        Neighbor *branch2 = brit->first->findNeighbor(brit->second);
        string label = brit->second->name;
        if (!label.empty()) {
            PUT_ATTR(branch1, label);
            PUT_ATTR(branch2, label);
            brit->second->name = "";
        }
    }
    
    rooted = params.is_rooted;
    MTreeSet trees(params.treeset_file.c_str(), rooted, params.tree_burnin, params.tree_max_count);
    double start_time = getRealTime();
    cout << "Computing rootstrap supports..." << endl;
    if (tree.rooted)
        tree.computeRootstrap(trees, false);
    else
        tree.computeRootstrapUnrooted(trees, params.root, false);
    cout << getRealTime() - start_time << " sec" << endl;
    
}
