<?xml version="1.0" encoding="utf-8"?>
<cain version="1.7">
  <listOfModels>
    <model id="Proctor2007_ubiquitine">
      <listOfParameters>
        <parameter expression="0.001" id="k63"/>
        <parameter expression="1e-08" id="k71"/>
        <parameter expression="2e-06" id="k2"/>
        <parameter expression="0.0002" id="k61r"/>
        <parameter expression="0.01" id="k1"/>
        <parameter expression="4e-06" id="k3"/>
        <parameter expression="1e-05" id="k67"/>
        <parameter expression="0.001" id="k73"/>
        <parameter expression="1e-08" id="k72"/>
        <parameter expression="0.0002" id="k62"/>
        <parameter expression="1e-05" id="k74"/>
        <parameter expression="0.01" id="k65"/>
        <parameter expression="1.7e-05" id="k61"/>
        <parameter expression="0.001" id="k64"/>
        <parameter expression="1e-05" id="k66"/>
        <parameter expression="1e-05" id="k68"/>
        <parameter expression="0" id="k69"/>
      </listOfParameters>
      <listOfCompartments>
        <compartment expression="1" id="cytosol"/>
      </listOfCompartments>
      <listOfSpecies>
        <species compartment="cytosol" initialAmount="500" id="NatP"/>
        <species compartment="cytosol" initialAmount="0" id="MisP"/>
        <species compartment="cytosol" initialAmount="500" id="Ub"/>
        <species compartment="cytosol" initialAmount="100" id="E1"/>
        <species compartment="cytosol" initialAmount="100" id="E2"/>
        <species compartment="cytosol" initialAmount="100" id="E3"/>
        <species compartment="cytosol" initialAmount="200" id="DUB"/>
        <species compartment="cytosol" initialAmount="100" id="Proteasome"/>
        <species compartment="cytosol" initialAmount="10" id="ROS"/>
        <species compartment="cytosol" initialAmount="0" id="E1_Ub"/>
        <species compartment="cytosol" initialAmount="0" id="E2_Ub"/>
        <species compartment="cytosol" initialAmount="0" id="E3_MisP"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub2"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub3"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub4"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub5"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub6"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub7"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub8"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub4_Proteasome"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub5_Proteasome"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub6_Proteasome"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub7_Proteasome"/>
        <species compartment="cytosol" initialAmount="0" id="MisP_Ub8_Proteasome"/>
        <species compartment="cytosol" initialAmount="10000" id="ATP"/>
        <species compartment="cytosol" initialAmount="1000" id="ADP"/>
        <species compartment="cytosol" initialAmount="1000" id="AMP"/>
        <species compartment="cytosol" initialAmount="1" id="Source"/>
        <species compartment="cytosol" initialAmount="0" id="degUb4"/>
        <species compartment="cytosol" initialAmount="0" id="degUb5"/>
        <species compartment="cytosol" initialAmount="0" id="degUb6"/>
        <species compartment="cytosol" initialAmount="0" id="degUb7"/>
        <species compartment="cytosol" initialAmount="0" id="degUb8"/>
        <species compartment="cytosol" initialAmount="0" id="totMisP"/>
        <species compartment="cytosol" initialAmount="0" id="refNatP"/>
        <species compartment="cytosol" initialAmount="0" id="AggP"/>
        <species compartment="cytosol" initialAmount="0" id="SeqAggP"/>
        <species compartment="cytosol" initialAmount="0" id="AggP_Proteasome"/>
      </listOfSpecies>
      <listOfReactions>
        <reaction propensity="k1" massAction="true" id="ProteinSynthesis">
          <listOfReactants>
            <speciesReference species="Source"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="NatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k2" massAction="true" id="Misfolding">
          <listOfReactants>
            <speciesReference species="NatP"/>
            <speciesReference species="ROS"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="ROS"/>
            <speciesReference species="totMisP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k3" massAction="true" id="Refolding">
          <listOfReactants>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="NatP"/>
            <speciesReference species="refNatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k61" massAction="true" id="MisPE3Binding">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="E3"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="E3_MisP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k61r" massAction="true" id="MisPE3Release">
          <listOfReactants>
            <speciesReference species="E3_MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="E3"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k62*E1*Ub*ATP)/(5000+ATP)" massAction="false" id="E1UbBinding">
          <listOfReactants>
            <speciesReference species="E1"/>
            <speciesReference species="Ub"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="E1_Ub"/>
            <speciesReference species="AMP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k63" massAction="true" id="E2UbBinding">
          <listOfReactants>
            <speciesReference species="E2"/>
            <speciesReference species="E1_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="E2_Ub"/>
            <speciesReference species="E1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k64" massAction="true" id="Monoubiquitination">
          <listOfReactants>
            <speciesReference species="E2_Ub"/>
            <speciesReference species="E3_MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="E2"/>
            <speciesReference species="E3"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination1">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination2">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination3">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination4">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination5">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination6">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k65" massAction="true" id="Polyubiquitination7">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="E2_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub8"/>
            <speciesReference species="E2"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination1">
          <listOfReactants>
            <speciesReference species="MisP_Ub8"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination2">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination3">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination4">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination5">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination6">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination7">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k66" massAction="true" id="Deubiqutination8">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="DUB"/>
            <speciesReference species="Ub"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k67" massAction="true" id="ProteasomeBinding1">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub4_Proteasome"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k67" massAction="true" id="ProteasomeBinding2">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub5_Proteasome"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k67" massAction="true" id="ProteasomeBinding3">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub6_Proteasome"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k67" massAction="true" id="ProteasomeBinding4">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub7_Proteasome"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k67" massAction="true" id="ProteasomeBinding5">
          <listOfReactants>
            <speciesReference species="MisP_Ub8"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub8_Proteasome"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k68" massAction="true" id="DeubiquitinationBoundMisP5">
          <listOfReactants>
            <speciesReference species="MisP_Ub8_Proteasome"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub7_Proteasome"/>
            <speciesReference species="Ub"/>
            <speciesReference species="DUB"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k68" massAction="true" id="DeubiquitinationBoundMisP4">
          <listOfReactants>
            <speciesReference species="MisP_Ub7_Proteasome"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub6_Proteasome"/>
            <speciesReference species="Ub"/>
            <speciesReference species="DUB"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k68" massAction="true" id="DeubiquitinationBoundMisP3">
          <listOfReactants>
            <speciesReference species="MisP_Ub6_Proteasome"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub5_Proteasome"/>
            <speciesReference species="Ub"/>
            <speciesReference species="DUB"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k68" massAction="true" id="DeubiquitinationBoundMisP2">
          <listOfReactants>
            <speciesReference species="MisP_Ub5_Proteasome"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub4_Proteasome"/>
            <speciesReference species="Ub"/>
            <speciesReference species="DUB"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k68" massAction="true" id="DeubiquitinationBoundMisP1">
          <listOfReactants>
            <speciesReference species="MisP_Ub4_Proteasome"/>
            <speciesReference species="DUB"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="Ub"/>
            <speciesReference species="DUB"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k69*MisP_Ub4_Proteasome*ATP)/(5000+ATP)" massAction="false" id="ProteasomeActivity1">
          <listOfReactants>
            <speciesReference species="MisP_Ub4_Proteasome"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="4" species="Ub"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="ADP"/>
            <speciesReference species="degUb4"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k69*MisP_Ub5_Proteasome*ATP)/(5000+ATP)" massAction="false" id="ProteasomeActivity2">
          <listOfReactants>
            <speciesReference species="MisP_Ub5_Proteasome"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="5" species="Ub"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="ADP"/>
            <speciesReference species="degUb5"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k69*MisP_Ub6_Proteasome*ATP)/(5000+ATP)" massAction="false" id="ProteasomeActivity3">
          <listOfReactants>
            <speciesReference species="MisP_Ub6_Proteasome"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="6" species="Ub"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="ADP"/>
            <speciesReference species="degUb6"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k69*MisP_Ub7_Proteasome*ATP)/(5000+ATP)" massAction="false" id="ProteasomeActivity4">
          <listOfReactants>
            <speciesReference species="MisP_Ub7_Proteasome"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="7" species="Ub"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="ADP"/>
            <speciesReference species="degUb7"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="(k69*MisP_Ub8_Proteasome*ATP)/(5000+ATP)" massAction="false" id="ProteasomeActivity5">
          <listOfReactants>
            <speciesReference species="MisP_Ub8_Proteasome"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="8" species="Ub"/>
            <speciesReference species="Proteasome"/>
            <speciesReference species="ADP"/>
            <speciesReference species="degUb8"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k71" massAction="true" id="Aggregation1">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k71" massAction="true" id="Aggregation2">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation3">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation4">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub2"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation5">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub3"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation6">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub4"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation7">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub5"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation8">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation9">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation10">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation11">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation12">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation13">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation14">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation15">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation16">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation17">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation18">
          <listOfReactants>
            <speciesReference species="MisP_Ub8"/>
            <speciesReference species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation19">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation20">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation21">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation22">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation23">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation24">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation25">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation26">
          <listOfReactants>
            <speciesReference species="MisP_Ub8"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation27">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub2"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation28">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub3"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation29">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub4"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation30">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub5"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation31">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation32">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation33">
          <listOfReactants>
            <speciesReference species="MisP_Ub"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation34">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub3"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation35">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub4"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation36">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub5"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation37">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation38">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation39">
          <listOfReactants>
            <speciesReference species="MisP_Ub2"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation40">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP_Ub4"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation41">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP_Ub5"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation42">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation43">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation44">
          <listOfReactants>
            <speciesReference species="MisP_Ub3"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation45">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="MisP_Ub5"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation46">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation47">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation48">
          <listOfReactants>
            <speciesReference species="MisP_Ub4"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation49">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="MisP_Ub6"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation50">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation51">
          <listOfReactants>
            <speciesReference species="MisP_Ub5"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation52">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="MisP_Ub7"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation53">
          <listOfReactants>
            <speciesReference species="MisP_Ub6"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k72" massAction="true" id="Aggregation54">
          <listOfReactants>
            <speciesReference species="MisP_Ub7"/>
            <speciesReference species="MisP_Ub8"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k73" massAction="true" id="SequesteringOfAggregates">
          <listOfReactants>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="SeqAggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k74" massAction="true" id="ProteasomeInhibtion">
          <listOfReactants>
            <speciesReference species="AggP"/>
            <speciesReference species="Proteasome"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP_Proteasome"/>
          </listOfProducts>
        </reaction>
      </listOfReactions>
    </model>
  </listOfModels>
  <listOfMethods>
    <method equilibrationTime="0.0" startTime="0.0" recordingTime="10.0" id="Direct" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="101" options="0"/>
  </listOfMethods>
  <random seed="2147483648">
  </random>
</cain>
