<?xml version="1.0" encoding="utf-8"?>
<cain version="1.7">
  <listOfModels>
    <model id="IncreaseROS" name="Hsp90model_basis510">
      <listOfParameters>
        <parameter expression="0.5" id="k13" name="k13"/>
        <parameter expression="0.5" id="k12" name="k12"/>
        <parameter expression="100" id="k11" name="k11"/>
        <parameter expression="0.01" id="k10" name="k10"/>
        <parameter expression="8.02e-09" id="k17" name="k17"/>
        <parameter expression="1000" id="k16" name="k16"/>
        <parameter expression="0.08" id="k15" name="k15"/>
        <parameter expression="0.05" id="k14" name="k14"/>
        <parameter expression="0.02" id="k19" name="k19"/>
        <parameter expression="12" id="k18" name="k18"/>
        <parameter expression="50" id="k3" name="k3"/>
        <parameter expression="2e-05" id="k2" name="k2"/>
        <parameter expression="10" id="k1" name="k1"/>
        <parameter expression="1e-07" id="k7" name="k7"/>
        <parameter expression="6e-07" id="k6" name="k6"/>
        <parameter expression="4e-06" id="k5" name="k5"/>
        <parameter expression="1e-05" id="k4" name="k4"/>
        <parameter expression="1" id="k9" name="k9"/>
        <parameter expression="500" id="k8" name="k8"/>
        <parameter expression="0.1" id="k20" name="k20"/>
        <parameter expression="0.00001" id="k21" name="k21"/>
      </listOfParameters>
      <listOfCompartments>
        <compartment expression="1" id="compartment"/>
      </listOfCompartments>
      <listOfSpecies>
        <species compartment="compartment" initialAmount="300000" name="Hsp90" id="Hsp90"/>
        <species compartment="compartment" initialAmount="5900" name="HCom" id="HCom"/>
        <species compartment="compartment" initialAmount="100" name="HSF1" id="HSF1"/>
        <species compartment="compartment" initialAmount="0" name="MisP" id="MisP"/>
        <species compartment="compartment" initialAmount="0" name="MCom" id="MCom"/>
        <species compartment="compartment" initialAmount="0" name="TriH" id="TriH"/>
        <species compartment="compartment" initialAmount="0" name="DiH" id="DiH"/>
        <species compartment="compartment" initialAmount="6000000" name="NatP" id="NatP"/>
        <species compartment="compartment" initialAmount="0" name="AggP" id="AggP"/>
        <species compartment="compartment" initialAmount="1" name="HSE" id="HSE"/>
        <species compartment="compartment" initialAmount="0" name="HSETriH" id="HSETriH"/>
        <species compartment="compartment" initialAmount="0" name="X" id="X"/>
        <species compartment="compartment" initialAmount="100" name="ROS" id="ROS"/>
        <species compartment="compartment" initialAmount="10000" name="ATP" id="ATP"/>
        <species compartment="compartment" initialAmount="1000" name="ADP" id="ADP"/>
        <species compartment="compartment" initialAmount="0" name="source" id="source"/>
      </listOfSpecies>
      <listOfReactions>
        <reaction propensity="k1" massAction="true" id="proteinSynthesis" name="proteinSynthesis">
          <listOfProducts>
            <speciesReference species="NatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k2" massAction="true" id="misfolding" name="misfolding">
          <listOfReactants>
            <speciesReference species="NatP"/>
            <speciesReference species="ROS"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k3" massAction="true" id="Hsp90MisPBinding" name="Hsp90MisPBinding">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k4" massAction="true" id="unsuccessulRefolding" name="unsuccessfulRefolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k5" massAction="true" id="refolding" name="refolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="NatP"/>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k6" massAction="true" id="proteinDegradation" name="proteinDegradation">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation1">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation2">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k8" massAction="true" id="Hsp90HSF1Binding" name="Hsp90HSF1Binding">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k9" massAction="true" id="Hsp90HSF1Release" name="Hsp90HSF1Release">
          <listOfReactants>
            <speciesReference species="HCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k10" massAction="true" id="dimerisation" name="dimerisation">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k11" massAction="true" id="trimerisation" name="trimerisation">
          <listOfReactants>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k12" massAction="true" id="deTrimerisation" name="deTrimerisation">
          <listOfReactants>
            <speciesReference species="TriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k13" massAction="true" id="deDimerisation" name="deDimerisation">
          <listOfReactants>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k14" massAction="true" id="HSETriHBinding" name="HSETriHBinding">
          <listOfReactants>
            <speciesReference species="TriH"/>
            <speciesReference species="HSE"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k15" massAction="true" id="HSETriHRelease" name="HSETriHRelease">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSE"/>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k16" massAction="true" id="Hsp90Transcription" name="Hsp90Transcription">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k17" massAction="true" id="Hsp90Degradation" name="Hsp90Degradation">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="1.0" massAction="true" id="countTime" name="countTime">
          <listOfProducts>
            <speciesReference species="X"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k18" massAction="true" id="ATPformation" name="ATPformation">
          <listOfReactants>
            <speciesReference species="ADP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ATP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k19" massAction="true" id="ATPconsumption" name="ATPconsumption">
          <listOfReactants>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k20" massAction="true" id="radicalFormation" name="radicalFormation">
          <listOfProducts>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k21" massAction="true" id="radicalScavenging" name="radicalScavenging">
          <listOfReactants>
            <speciesReference species="ROS"/>
          </listOfReactants>
        </reaction>
      </listOfReactions>
    </model>
    <model id="Unstressed" name="Hsp90model_basis510">
      <listOfParameters>
        <parameter expression="0.5" id="k13" name="k13"/>
        <parameter expression="0.5" id="k12" name="k12"/>
        <parameter expression="100" id="k11" name="k11"/>
        <parameter expression="0.01" id="k10" name="k10"/>
        <parameter expression="8.02e-09" id="k17" name="k17"/>
        <parameter expression="1000" id="k16" name="k16"/>
        <parameter expression="0.08" id="k15" name="k15"/>
        <parameter expression="0.05" id="k14" name="k14"/>
        <parameter expression="0.02" id="k19" name="k19"/>
        <parameter expression="12" id="k18" name="k18"/>
        <parameter expression="50" id="k3" name="k3"/>
        <parameter expression="2e-05" id="k2" name="k2"/>
        <parameter expression="10" id="k1" name="k1"/>
        <parameter expression="1e-07" id="k7" name="k7"/>
        <parameter expression="6e-07" id="k6" name="k6"/>
        <parameter expression="4e-06" id="k5" name="k5"/>
        <parameter expression="1e-05" id="k4" name="k4"/>
        <parameter expression="1" id="k9" name="k9"/>
        <parameter expression="500" id="k8" name="k8"/>
        <parameter expression="0.1" id="k20" name="k20"/>
        <parameter expression="0.001" id="k21" name="k21"/>
      </listOfParameters>
      <listOfCompartments>
        <compartment expression="1" id="compartment"/>
      </listOfCompartments>
      <listOfSpecies>
        <species compartment="compartment" initialAmount="300000" name="Hsp90" id="Hsp90"/>
        <species compartment="compartment" initialAmount="5900" name="HCom" id="HCom"/>
        <species compartment="compartment" initialAmount="100" name="HSF1" id="HSF1"/>
        <species compartment="compartment" initialAmount="0" name="MisP" id="MisP"/>
        <species compartment="compartment" initialAmount="0" name="MCom" id="MCom"/>
        <species compartment="compartment" initialAmount="0" name="TriH" id="TriH"/>
        <species compartment="compartment" initialAmount="0" name="DiH" id="DiH"/>
        <species compartment="compartment" initialAmount="6000000" name="NatP" id="NatP"/>
        <species compartment="compartment" initialAmount="0" name="AggP" id="AggP"/>
        <species compartment="compartment" initialAmount="1" name="HSE" id="HSE"/>
        <species compartment="compartment" initialAmount="0" name="HSETriH" id="HSETriH"/>
        <species compartment="compartment" initialAmount="0" name="X" id="X"/>
        <species compartment="compartment" initialAmount="100" name="ROS" id="ROS"/>
        <species compartment="compartment" initialAmount="10000" name="ATP" id="ATP"/>
        <species compartment="compartment" initialAmount="1000" name="ADP" id="ADP"/>
        <species compartment="compartment" initialAmount="0" name="source" id="source"/>
      </listOfSpecies>
      <listOfReactions>
        <reaction propensity="k1" massAction="true" id="proteinSynthesis" name="proteinSynthesis">
          <listOfProducts>
            <speciesReference species="NatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k2" massAction="true" id="misfolding" name="misfolding">
          <listOfReactants>
            <speciesReference species="NatP"/>
            <speciesReference species="ROS"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k3" massAction="true" id="Hsp90MisPBinding" name="Hsp90MisPBinding">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k4" massAction="true" id="unsuccessulRefolding" name="unsuccessfulRefolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k5" massAction="true" id="refolding" name="refolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="NatP"/>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k6" massAction="true" id="proteinDegradation" name="proteinDegradation">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation1">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation2">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k8" massAction="true" id="Hsp90HSF1Binding" name="Hsp90HSF1Binding">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k9" massAction="true" id="Hsp90HSF1Release" name="Hsp90HSF1Release">
          <listOfReactants>
            <speciesReference species="HCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k10" massAction="true" id="dimerisation" name="dimerisation">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k11" massAction="true" id="trimerisation" name="trimerisation">
          <listOfReactants>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k12" massAction="true" id="deTrimerisation" name="deTrimerisation">
          <listOfReactants>
            <speciesReference species="TriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k13" massAction="true" id="deDimerisation" name="deDimerisation">
          <listOfReactants>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k14" massAction="true" id="HSETriHBinding" name="HSETriHBinding">
          <listOfReactants>
            <speciesReference species="TriH"/>
            <speciesReference species="HSE"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k15" massAction="true" id="HSETriHRelease" name="HSETriHRelease">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSE"/>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k16" massAction="true" id="Hsp90Transcription" name="Hsp90Transcription">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k17" massAction="true" id="Hsp90Degradation" name="Hsp90Degradation">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="1.0" massAction="true" id="countTime" name="countTime">
          <listOfProducts>
            <speciesReference species="X"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k18" massAction="true" id="ATPformation" name="ATPformation">
          <listOfReactants>
            <speciesReference species="ADP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ATP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k19" massAction="true" id="ATPconsumption" name="ATPconsumption">
          <listOfReactants>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k20" massAction="true" id="radicalFormation" name="radicalFormation">
          <listOfProducts>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k21" massAction="true" id="radicalScavenging" name="radicalScavenging">
          <listOfReactants>
            <speciesReference species="ROS"/>
          </listOfReactants>
        </reaction>
      </listOfReactions>
    </model>
    <model id="Halved" name="Hsp90model_basis510">
      <listOfParameters>
        <parameter expression="0.5" id="k13" name="k13"/>
        <parameter expression="0.5" id="k12" name="k12"/>
        <parameter expression="100" id="k11" name="k11"/>
        <parameter expression="0.01" id="k10" name="k10"/>
        <parameter expression="8.02e-09" id="k17" name="k17"/>
        <parameter expression="1000" id="k16" name="k16"/>
        <parameter expression="0.08" id="k15" name="k15"/>
        <parameter expression="0.05" id="k14" name="k14"/>
        <parameter expression="0.02" id="k19" name="k19"/>
        <parameter expression="12" id="k18" name="k18"/>
        <parameter expression="50" id="k3" name="k3"/>
        <parameter expression="2e-05" id="k2" name="k2"/>
        <parameter expression="10" id="k1" name="k1"/>
        <parameter expression="1e-07" id="k7" name="k7"/>
        <parameter expression="6e-07" id="k6" name="k6"/>
        <parameter expression="4e-06" id="k5" name="k5"/>
        <parameter expression="1e-05" id="k4" name="k4"/>
        <parameter expression="1" id="k9" name="k9"/>
        <parameter expression="500" id="k8" name="k8"/>
        <parameter expression="0.1" id="k20" name="k20"/>
        <parameter expression="0.001" id="k21" name="k21"/>
      </listOfParameters>
      <listOfCompartments>
        <compartment expression="1" id="compartment"/>
      </listOfCompartments>
      <listOfSpecies>
        <species compartment="compartment" initialAmount="82185" name="Hsp90" id="Hsp90"/>
        <species compartment="compartment" initialAmount="6000" name="HCom" id="HCom"/>
        <species compartment="compartment" initialAmount="0" name="HSF1" id="HSF1"/>
        <species compartment="compartment" initialAmount="0" name="MisP" id="MisP"/>
        <species compartment="compartment" initialAmount="449299" name="MCom" id="MCom"/>
        <species compartment="compartment" initialAmount="0" name="TriH" id="TriH"/>
        <species compartment="compartment" initialAmount="0" name="DiH" id="DiH"/>
        <species compartment="compartment" initialAmount="4953170" name="NatP" id="NatP"/>
        <species compartment="compartment" initialAmount="376418" name="AggP" id="AggP"/>
        <species compartment="compartment" initialAmount="1" name="HSE" id="HSE"/>
        <species compartment="compartment" initialAmount="0" name="HSETriH" id="HSETriH"/>
        <species compartment="compartment" initialAmount="1094" name="X" id="X"/>
        <species compartment="compartment" initialAmount="86" name="ROS" id="ROS"/>
        <species compartment="compartment" initialAmount="9588" name="ATP" id="ATP"/>
        <species compartment="compartment" initialAmount="1412" name="ADP" id="ADP"/>
        <species compartment="compartment" initialAmount="0" name="source" id="source"/>
      </listOfSpecies>
      <listOfReactions>
        <reaction propensity="k1" massAction="true" id="proteinSynthesis" name="proteinSynthesis">
          <listOfProducts>
            <speciesReference species="NatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k2" massAction="true" id="misfolding" name="misfolding">
          <listOfReactants>
            <speciesReference species="NatP"/>
            <speciesReference species="ROS"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k3" massAction="true" id="Hsp90MisPBinding" name="Hsp90MisPBinding">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k4" massAction="true" id="unsuccessulRefolding" name="unsuccessfulRefolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k5" massAction="true" id="refolding" name="refolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="NatP"/>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k6" massAction="true" id="proteinDegradation" name="proteinDegradation">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation1">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation2">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k8" massAction="true" id="Hsp90HSF1Binding" name="Hsp90HSF1Binding">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k9" massAction="true" id="Hsp90HSF1Release" name="Hsp90HSF1Release">
          <listOfReactants>
            <speciesReference species="HCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k10" massAction="true" id="dimerisation" name="dimerisation">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k11" massAction="true" id="trimerisation" name="trimerisation">
          <listOfReactants>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k12" massAction="true" id="deTrimerisation" name="deTrimerisation">
          <listOfReactants>
            <speciesReference species="TriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k13" massAction="true" id="deDimerisation" name="deDimerisation">
          <listOfReactants>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k14" massAction="true" id="HSETriHBinding" name="HSETriHBinding">
          <listOfReactants>
            <speciesReference species="TriH"/>
            <speciesReference species="HSE"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k15" massAction="true" id="HSETriHRelease" name="HSETriHRelease">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSE"/>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k16" massAction="true" id="Hsp90Transcription" name="Hsp90Transcription">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k17" massAction="true" id="Hsp90Degradation" name="Hsp90Degradation">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="1.0" massAction="true" id="countTime" name="countTime">
          <listOfProducts>
            <speciesReference species="X"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k18" massAction="true" id="ATPformation" name="ATPformation">
          <listOfReactants>
            <speciesReference species="ADP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ATP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k19" massAction="true" id="ATPconsumption" name="ATPconsumption">
          <listOfReactants>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k20" massAction="true" id="radicalFormation" name="radicalFormation">
          <listOfProducts>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k21" massAction="true" id="radicalScavenging" name="radicalScavenging">
          <listOfReactants>
            <speciesReference species="ROS"/>
          </listOfReactants>
        </reaction>
      </listOfReactions>
    </model>
    <model id="Doubled" name="Hsp90model_basis510">
      <listOfParameters>
        <parameter expression="0.5" id="k13" name="k13"/>
        <parameter expression="0.5" id="k12" name="k12"/>
        <parameter expression="100" id="k11" name="k11"/>
        <parameter expression="0.01" id="k10" name="k10"/>
        <parameter expression="8.02e-09" id="k17" name="k17"/>
        <parameter expression="1000" id="k16" name="k16"/>
        <parameter expression="0.08" id="k15" name="k15"/>
        <parameter expression="0.05" id="k14" name="k14"/>
        <parameter expression="0.02" id="k19" name="k19"/>
        <parameter expression="12" id="k18" name="k18"/>
        <parameter expression="50" id="k3" name="k3"/>
        <parameter expression="2e-05" id="k2" name="k2"/>
        <parameter expression="10" id="k1" name="k1"/>
        <parameter expression="1e-07" id="k7" name="k7"/>
        <parameter expression="6e-07" id="k6" name="k6"/>
        <parameter expression="4e-06" id="k5" name="k5"/>
        <parameter expression="1e-05" id="k4" name="k4"/>
        <parameter expression="1" id="k9" name="k9"/>
        <parameter expression="500" id="k8" name="k8"/>
        <parameter expression="0.1" id="k20" name="k20"/>
        <parameter expression="0.001" id="k21" name="k21"/>
      </listOfParameters>
      <listOfCompartments>
        <compartment expression="1" id="compartment"/>
      </listOfCompartments>
      <listOfSpecies>
        <species compartment="compartment" initialAmount="15207" name="Hsp90" id="Hsp90"/>
        <species compartment="compartment" initialAmount="6000" name="HCom" id="HCom"/>
        <species compartment="compartment" initialAmount="0" name="HSF1" id="HSF1"/>
        <species compartment="compartment" initialAmount="0" name="MisP" id="MisP"/>
        <species compartment="compartment" initialAmount="298829" name="MCom" id="MCom"/>
        <species compartment="compartment" initialAmount="0" name="TriH" id="TriH"/>
        <species compartment="compartment" initialAmount="0" name="DiH" id="DiH"/>
        <species compartment="compartment" initialAmount="5705920" name="NatP" id="NatP"/>
        <species compartment="compartment" initialAmount="1" name="AggP" id="AggP"/>
        <species compartment="compartment" initialAmount="1" name="HSE" id="HSE"/>
        <species compartment="compartment" initialAmount="0" name="HSETriH" id="HSETriH"/>
        <species compartment="compartment" initialAmount="476" name="X" id="X"/>
        <species compartment="compartment" initialAmount="202" name="ROS" id="ROS"/>
        <species compartment="compartment" initialAmount="9978" name="ATP" id="ATP"/>
        <species compartment="compartment" initialAmount="1022" name="ADP" id="ADP"/>
        <species compartment="compartment" initialAmount="0" name="source" id="source"/>
      </listOfSpecies>
      <listOfReactions>
        <reaction propensity="k1" massAction="true" id="proteinSynthesis" name="proteinSynthesis">
          <listOfProducts>
            <speciesReference species="NatP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k2" massAction="true" id="misfolding" name="misfolding">
          <listOfReactants>
            <speciesReference species="NatP"/>
            <speciesReference species="ROS"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k3" massAction="true" id="Hsp90MisPBinding" name="Hsp90MisPBinding">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k4" massAction="true" id="unsuccessulRefolding" name="unsuccessfulRefolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="MisP"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k5" massAction="true" id="refolding" name="refolding">
          <listOfReactants>
            <speciesReference species="MCom"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="NatP"/>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k6" massAction="true" id="proteinDegradation" name="proteinDegradation">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation1">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="MisP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k7" massAction="true" id="proteinAggregation2">
          <listOfReactants>
            <speciesReference species="MisP"/>
            <speciesReference species="AggP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="AggP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k8" massAction="true" id="Hsp90HSF1Binding" name="Hsp90HSF1Binding">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HCom"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k9" massAction="true" id="Hsp90HSF1Release" name="Hsp90HSF1Release">
          <listOfReactants>
            <speciesReference species="HCom"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="Hsp90"/>
            <speciesReference species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k10" massAction="true" id="dimerisation" name="dimerisation">
          <listOfReactants>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k11" massAction="true" id="trimerisation" name="trimerisation">
          <listOfReactants>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k12" massAction="true" id="deTrimerisation" name="deTrimerisation">
          <listOfReactants>
            <speciesReference species="TriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSF1"/>
            <speciesReference species="DiH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k13" massAction="true" id="deDimerisation" name="deDimerisation">
          <listOfReactants>
            <speciesReference species="DiH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference stoichiometry="2" species="HSF1"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k14" massAction="true" id="HSETriHBinding" name="HSETriHBinding">
          <listOfReactants>
            <speciesReference species="TriH"/>
            <speciesReference species="HSE"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k15" massAction="true" id="HSETriHRelease" name="HSETriHRelease">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSE"/>
            <speciesReference species="TriH"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k16" massAction="true" id="Hsp90Transcription" name="Hsp90Transcription">
          <listOfReactants>
            <speciesReference species="HSETriH"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="HSETriH"/>
            <speciesReference species="Hsp90"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k17" massAction="true" id="Hsp90Degradation" name="Hsp90Degradation">
          <listOfReactants>
            <speciesReference species="Hsp90"/>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="1.0" massAction="true" id="countTime" name="countTime">
          <listOfProducts>
            <speciesReference species="X"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k18" massAction="true" id="ATPformation" name="ATPformation">
          <listOfReactants>
            <speciesReference species="ADP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ATP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k19" massAction="true" id="ATPconsumption" name="ATPconsumption">
          <listOfReactants>
            <speciesReference species="ATP"/>
          </listOfReactants>
          <listOfProducts>
            <speciesReference species="ADP"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k20" massAction="true" id="radicalFormation" name="radicalFormation">
          <listOfProducts>
            <speciesReference species="ROS"/>
          </listOfProducts>
        </reaction>
        <reaction propensity="k21" massAction="true" id="radicalScavenging" name="radicalScavenging">
          <listOfReactants>
            <speciesReference species="ROS"/>
          </listOfReactants>
        </reaction>
      </listOfReactions>
    </model>
  </listOfModels>
  <listOfMethods>
    <method equilibrationTime="0.0" startTime="0.0" recordingTime="480.0" id="Stage1" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="49" options="0"/>
    <method equilibrationTime="0.0" startTime="0.0" recordingTime="10000.0" id="Direct1e4" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="1001" options="0"/>
    <method equilibrationTime="0.0" startTime="0.0" recordingTime="100000.0" id="Direct1e5" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="1001" options="0"/>
    <method equilibrationTime="0.0" startTime="1080.0" recordingTime="920.0" id="Stage3" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="93" options="0"/>
    <method equilibrationTime="0.0" startTime="480.0" recordingTime="600.0" id="Stage2" category="0" numberOfBins="32" multiplicity="4" method="0" timeDependence="0" numberOfFrames="61" options="0"/>
  </listOfMethods>
  <random seed="2147483648">
  </random>
</cain>
